Discovery Early Career Researcher Award - Grant ID: DE160101570
Funder
Australian Research Council
Funding Amount
$352,000.00
Summary
Inducible hyper-expression as a tool for metabolic engineering. This project aims to develop methods to improve plant natural products yields and diversify the products manufactured from a wide array of plant species. Valuable plant metabolites, including chemotherapeutics and opiates, are usually synthesised in minute amounts and can be so complex they can’t be chemically manufactured, limiting their use and affordability. This project aims to develop an inducible system that confers hyper-elev ....Inducible hyper-expression as a tool for metabolic engineering. This project aims to develop methods to improve plant natural products yields and diversify the products manufactured from a wide array of plant species. Valuable plant metabolites, including chemotherapeutics and opiates, are usually synthesised in minute amounts and can be so complex they can’t be chemically manufactured, limiting their use and affordability. This project aims to develop an inducible system that confers hyper-elevated levels of gene expression and independent control of multiple genes involved in metabolite synthesis in the same host. This technology is expected to enable flexible multi-trait bio-factories to be developed.Read moreRead less
Improving crops from the ground up: genetic solutions to optimise roots. This project aims to develop future crops with optimised root systems by overcoming genetic constraints that currently restrict their potential. Exploiting advances in genomics, transcriptomics, epigenomics and genome editing, this project expects to advance understanding of the biology and genetic controls of root development and responses to concurrent stressors, including drought, nutrient deficiency and soil-borne disea ....Improving crops from the ground up: genetic solutions to optimise roots. This project aims to develop future crops with optimised root systems by overcoming genetic constraints that currently restrict their potential. Exploiting advances in genomics, transcriptomics, epigenomics and genome editing, this project expects to advance understanding of the biology and genetic controls of root development and responses to concurrent stressors, including drought, nutrient deficiency and soil-borne disease. It is anticipated that project outcomes will support the development of crops equipped with novel root traits, enhancing resource-use efficiency and yield stability amid climate variability. This globally relevant research is designed to benefit the sustainability and profitability of the Australian grains industry.Read moreRead less
Modulating Inflammatory And Fibrogenic Pathways In Kidney Disease Using A Novel Antagonist Of Protease-Activated-Receptor-2
Funder
National Health and Medical Research Council
Funding Amount
$581,116.00
Summary
Chronic kidney disease (CKD) now affects 10% of adults in industrialised countries. Current treatments are largely ineffective. Thus developing better CKD treatments will have substantial public health benefit. Three well established and clinically relevant animal models of kidney disease will be used to test the ability of a new experimental anti-inflammatory drug, developed by members of this research team at The University of Queensland, to prevent or lessen the progression of CKD.
Cellular Regulation Of Receptor Signalling And Cytokine Responses
Funder
National Health and Medical Research Council
Funding Amount
$859,288.00
Summary
Cell surface receptors and signalling pathways elicit the release of cytokines, or chemical messengers, to control inflammation, which is the body’s response to infection or danger. We have discovered a new signalling pathway that can turn off inflammation and help prevent inflammatory disease. Our studies will now define the molecular details of this pathway and show how new and existing drugs targeting this pathway can be optimally used to treat inflammation and cancer.
Discovery Early Career Researcher Award - Grant ID: DE210100854
Funder
Australian Research Council
Funding Amount
$461,249.00
Summary
Model-directed bioengineering strategy for accelerating crop improvement. The aim is to use an advanced mechanistic crop model to investigate the interacting plant physiological processes that define yield consequences, using a sorghum model. This will involve unravelling the complex relationship between leaf gas exchange properties and crop field performance. Through a unique combination of model prediction and gene editing to target the photosynthetic pathway and stomata, the research is expec ....Model-directed bioengineering strategy for accelerating crop improvement. The aim is to use an advanced mechanistic crop model to investigate the interacting plant physiological processes that define yield consequences, using a sorghum model. This will involve unravelling the complex relationship between leaf gas exchange properties and crop field performance. Through a unique combination of model prediction and gene editing to target the photosynthetic pathway and stomata, the research is expected to gain a deep mechanistic understanding of the underpinning processes and drive the transfer of promising bioengineering targets into crops. The research is expected to discover new avenues for crop improvement, and significantly benefit crop breeding and food production capacity.Read moreRead less
Macrophages are important cells at the front-line of immunity where one of their main roles is to release anti-bacterial proteins. We will study the macrophage molecules, subcellular organelles and pathways that help to release these proteins to kill bacteria and fight infection. Our studies will identify new cellular targets for boosting immunity and treating inherited diseases with defective macrophage function.
Nettles & toxic toupees: the molecular weaponry of venomous caterpillars. This project aims to investigate the structure, function and evolution of peptide toxins in venoms made by caterpillars in superfamily Zygaenoidea. Caterpillars in this group are covered in spines that inject pain-causing venoms, and this protects them from vertebrate and invertebrate predators. This project will test if peptides in this venom cause pain by pharmacological modulation of mammalian ion channels and signallin ....Nettles & toxic toupees: the molecular weaponry of venomous caterpillars. This project aims to investigate the structure, function and evolution of peptide toxins in venoms made by caterpillars in superfamily Zygaenoidea. Caterpillars in this group are covered in spines that inject pain-causing venoms, and this protects them from vertebrate and invertebrate predators. This project will test if peptides in this venom cause pain by pharmacological modulation of mammalian ion channels and signalling receptors, and if they have insecticidal properties. The first three-dimensional structures of caterpillar venom peptides will also be solved. Genomes of representatives of two different zygaenoid families will be produced, and genomic techniques will be used to elucidate how venom use evolved at the molecular level.Read moreRead less