Myeloma Plasma Cell Dormancy - 'Eradicating The Sleeping Giant'
Funder
National Health and Medical Research Council
Funding Amount
$834,428.00
Summary
Multiple myeloma is a fatal cancer that develops in the skeleton. Current therapies are initially effective, but patients develop resistance and the disease returns. This makes the search for drugs to overcome resistance a priority. Myeloma cells can hide in bone in a dormant state where they are insensitive to chemotherapy. We have identified new drug targets in dormant cells. We are investigating whether these new targets can be used eradicate myeloma cells and cure the disease.
Defining Epigenetic Predictors Of Long-term Outcomes Of Preterm Birth
Funder
National Health and Medical Research Council
Funding Amount
$409,408.00
Summary
On average, those born premature do worse health-wise than those born at term. However, some do worse than others. Our aim is to identify these people at birth to better help doctors and parents to closely monitor their health. For this, we will be “reading the diary of pregnancy” in the molecules added to chromosomes in blood during pregnancy in young adults with will characterised states of health. We will analyse DNA from blood that we will extract from stored heel prick spots.
Targeting PI3K-regulated Small Non-coding RNAs To Restore Cardiac Function
Funder
National Health and Medical Research Council
Funding Amount
$610,204.00
Summary
Heart failure affects approximately 2.4% of the adult population and over 11% of people over 80 years old. The majority of existing therapies slow, rather than reverse heart failure progression. The primary goal of this study is to determine whether regulating novel regulatory genes can enhance cardiac function in a setting of heart failure. Ultimately, technologies that target these genes may lead to innovative pharmacotherapies in the clinical management of heart failure.
The Contribution Of Subunit Interfaces To Receptor Activation In Ligand Gated Ion Channels
Funder
National Health and Medical Research Council
Funding Amount
$309,070.00
Summary
This project seeks to provide insights into new mechanisms that could be used to enhance or inhibit neuronal signalling. The family of pentameric neurotransmitter receptors that are key components in the process of neuronal signalling and are the target of this study. It will investigate the molecular motions that occur when the receptor shifts from the resting state to the activated state in the presence of neurotransmitter. This critical to understanding the normal function of these receptors ....This project seeks to provide insights into new mechanisms that could be used to enhance or inhibit neuronal signalling. The family of pentameric neurotransmitter receptors that are key components in the process of neuronal signalling and are the target of this study. It will investigate the molecular motions that occur when the receptor shifts from the resting state to the activated state in the presence of neurotransmitter. This critical to understanding the normal function of these receptors in the brain and how they can be modulated.Read moreRead less
Topological order and anyons: quantum engineering of emergent physics. Australia is recognized as one of the world leaders in the area of quantum information and computation. As a frontier technology with tremendous potential but engineering challenges it is vital we expand our theoretical landscape to better steer experimental development. A promising new paradigm is topological quantum computation which uses particles with exotic statistics called anyons that do not exist naturally in three d ....Topological order and anyons: quantum engineering of emergent physics. Australia is recognized as one of the world leaders in the area of quantum information and computation. As a frontier technology with tremendous potential but engineering challenges it is vital we expand our theoretical landscape to better steer experimental development. A promising new paradigm is topological quantum computation which uses particles with exotic statistics called anyons that do not exist naturally in three dimensions but can be engineered to emerge in two dimensional spin lattices. Our bottom up research program would help place Australia at the forefront of these ideas. As a field which combines tools from mathematics, computer science, and physics this project will provide world class training to young researchers.Read moreRead less
The Effects Of Estrogen-Responsive B Box Protein On Retinoid Sensitivity In Cancer And Its Significance In Development
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
Although effective, many cancer drugs often lead to side effects, especially in children. New therapies are needed that specifically target cancer cells while leaving normal cells unaffected. I am studying a novel protein (EBBP) which I believe has an important role in cancer cell growth. By studying EBBP I aim to be able to increase the effectiveness of the low toxic chemotherapy retinoic acid without increased side effects, as well as understand the functional role of EBBP in cancer cells.
Atomic tests of unification theories. Although the standard model of particle physics has withstood decades of intensive experimental tests, it is widely believed to be merely a low-energy manifestation of a "true" theory that unifies the four forces of nature. While some searches for new physics beyond the standard model are performed at high-energy particle accelerators, a very sensitive probe can be done at low energies in atomic and molecular measurements of weak interaction effects. This pr ....Atomic tests of unification theories. Although the standard model of particle physics has withstood decades of intensive experimental tests, it is widely believed to be merely a low-energy manifestation of a "true" theory that unifies the four forces of nature. While some searches for new physics beyond the standard model are performed at high-energy particle accelerators, a very sensitive probe can be done at low energies in atomic and molecular measurements of weak interaction effects. This project is devoted to a theoretical investigation of weak interaction effects in atoms, molecules, and nuclei. It will provide improved tests of unified theories.Read moreRead less
Atomic clocks, space-time variation of fundamental constants, violation of fundamental symmetries and tests of unification theories. The project will help to establish Australia among the leaders in important areas of modern science: tests of theories unifying all physical forces and cosmology, search for variation of the fundamental forces of Nature and making super precise atomic clocks. The atomic clocks are used in all navigation (current GPS and future Galileo) systems and many other import ....Atomic clocks, space-time variation of fundamental constants, violation of fundamental symmetries and tests of unification theories. The project will help to establish Australia among the leaders in important areas of modern science: tests of theories unifying all physical forces and cosmology, search for variation of the fundamental forces of Nature and making super precise atomic clocks. The atomic clocks are used in all navigation (current GPS and future Galileo) systems and many other important applications. The training of students and researchers combined with a rich international collaborative program will insure that Australia is well placed to prepare for the approaching revolution in physics and cosmology.Read moreRead less
Violation of fundamental symmetries and test of unification models. This project is devoted to a theoretical investigation of the atomic and nuclear effects of parity and time invariance violation. Measurements of these effects provide accurate tests of unification theories of elementary particles. Effects of weak interactions are normally very small, and we want to look for possibilities to enhance these effects. We also plan to search for new effects and tests of the unification theories an ....Violation of fundamental symmetries and test of unification models. This project is devoted to a theoretical investigation of the atomic and nuclear effects of parity and time invariance violation. Measurements of these effects provide accurate tests of unification theories of elementary particles. Effects of weak interactions are normally very small, and we want to look for possibilities to enhance these effects. We also plan to search for new effects and tests of the unification theories and develop accurate method of atomic calculations.Read moreRead less
Test of unification theories in atomic and nuclear phenomena. This project will help to establish Australia among the leaders in important areas of modern science: tests of models unifying all physical forces and search for variation of fundamental constants of Nature. It may help to create new theory unifying physics and cosmology, and may reveal hypothetical extra dimensions in our Universe, or many different sub-Universes. The training of students and researchers combined with a rich interna ....Test of unification theories in atomic and nuclear phenomena. This project will help to establish Australia among the leaders in important areas of modern science: tests of models unifying all physical forces and search for variation of fundamental constants of Nature. It may help to create new theory unifying physics and cosmology, and may reveal hypothetical extra dimensions in our Universe, or many different sub-Universes. The training of students and researchers combined with a rich international collaborative program will ensure that Australia is well-placed to prepare for the approaching revolution in physics and cosmology. Read moreRead less