Dissecting The Pseudoexfoliation Syndrome With Complementary Genetic, Proteomic And Biophysical Strategies
Funder
National Health and Medical Research Council
Funding Amount
$490,352.00
Summary
Pseudoexfoliation syndrome (PEX) is an eye condition in which flaky material deposits in the eye, greatly increasing the risk of cataract and glaucoma which can lead to blindness. PEX is also associated with heart disease, strokes and aneurysms. Cataract surgery in PEX patients has a higher rate of complications. In this project we will determine the nature of PEX material and why it forms. This knowlege will facilitate better diagnosis and treatment of PEX preventing associated blindness.
Evolutionary, macroecological and phylogenetic patterns in Australasian freshwater crayfish. This project connects Australian systematists to a worldwide project that involves all of the world's living experts on freshwater crayfish evolution in a coordinated effort to answer some very important evolutionary questions. It involves a group of invertebrate animals that are not only readily recognisable, but which in Australia includes the world's largest and the world's most terrestrial crayfish s ....Evolutionary, macroecological and phylogenetic patterns in Australasian freshwater crayfish. This project connects Australian systematists to a worldwide project that involves all of the world's living experts on freshwater crayfish evolution in a coordinated effort to answer some very important evolutionary questions. It involves a group of invertebrate animals that are not only readily recognisable, but which in Australia includes the world's largest and the world's most terrestrial crayfish species. Information gained from the project will contribute to the management of crayfish biodiversity, identification of threatened species and tools to identify these prominent and important members of Australian freshwater ecosystems.Read moreRead less
A novel top-down approach to ecosystem management using multivariate foraging strategies of an iconic marine top-predator. Understanding predator aggregation patterns in relation to marine productivity is critical in designing ecosystem-level conservation plans for protecting marine habitats and species. The project aims to develop a new approach to measure prey abundance and availability in the marine ecosystem for the management of resources of top-predators. This will be of specific benefit i ....A novel top-down approach to ecosystem management using multivariate foraging strategies of an iconic marine top-predator. Understanding predator aggregation patterns in relation to marine productivity is critical in designing ecosystem-level conservation plans for protecting marine habitats and species. The project aims to develop a new approach to measure prey abundance and availability in the marine ecosystem for the management of resources of top-predators. This will be of specific benefit in areas where a strong need exists for conservation of prey species with economic importance too low to justify expensive at-sea research.Read moreRead less
Understanding the biological functions of the karrikin-responsive signaling system of plants in growth, development and responses to the environment. A new signalling system in plants, related to that of strigolactone hormones but evolutionarily more ancient and functionally distinct, has been discovered. It is defined by the Karrkin-Insensitive-2 (KAI2) protein discovered by its ability to confer responsiveness to karrikins from bushfires. The KAI2 system influences seed germination, and develo ....Understanding the biological functions of the karrikin-responsive signaling system of plants in growth, development and responses to the environment. A new signalling system in plants, related to that of strigolactone hormones but evolutionarily more ancient and functionally distinct, has been discovered. It is defined by the Karrkin-Insensitive-2 (KAI2) protein discovered by its ability to confer responsiveness to karrikins from bushfires. The KAI2 system influences seed germination, and development of seedlings, leaves and potentially roots. This project will use KAI2 mutants and transgenic plants to define the biological functions of KAI2 signalling, and its interactions with other signalling systems. New genes central to KAI2 signalling and responses will be identified for functional analysis. The research will reveal the significance of this new signalling system in plant biology. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100041
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
A high-resolution isotope facility for low cost analysis of water, plant, and soil/sediment samples to understand environmental change. The most significant environmental challenges facing Australia include ensuring sustainable management of our water resources and conservation of both terrestrial and marine biodiversity, particularly in the face of our changing climate and land-use. The new instruments will accelerate progress across a number of projects aimed at understanding the developme ....A high-resolution isotope facility for low cost analysis of water, plant, and soil/sediment samples to understand environmental change. The most significant environmental challenges facing Australia include ensuring sustainable management of our water resources and conservation of both terrestrial and marine biodiversity, particularly in the face of our changing climate and land-use. The new instruments will accelerate progress across a number of projects aimed at understanding the development of groundwater resources, the relative dependency of ecosystems on groundwater versus soil and surface water, and an assessment of the likely impacts of altered hydrology, especially dewatering and salinisation, on ecosystems. In addition, they will also be used to extend our knowledge of climate variability in the recent past and increase understanding of critical marine resources.Read moreRead less