Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnol ....Evolution and mechanisms of interactions in biofilm communities. This project aims to study the long-term experimental evolution of a mixed species bacterial biofilm community. This project expects to gain understanding of the genetic and physiological basis of community evolution. Expected outcomes of this project will be an understanding of how synthetic communities evolve. This will significantly benefit the use of synthetic communities relevant to fields such as antibiotic design, biotechnology, bioremediation, and synthetic biology where evolution can be inhibited or exploited, respectively.Read moreRead less
A single vaccine for influenza and pneumonia. Influenza and bacterial pneumonia collaborate to kill millions of people each year. This project aims to develop a single vaccine that will provide long-lasting protection against both influenza and pneumonia.
ARC Centre of Excellence - Structural and Functional Microbial Genomics. The research falls under the National Research Priority Frontier Technologies for Building and Transforming Australian Industries, with the priority goal of frontier technologies. The research has commercial applications, such as the development of novel antimicrobials and vaccines, with potentially enormous impact in the biotechnology area of biomedical health and the primary industries. In addition, the project will use ....ARC Centre of Excellence - Structural and Functional Microbial Genomics. The research falls under the National Research Priority Frontier Technologies for Building and Transforming Australian Industries, with the priority goal of frontier technologies. The research has commercial applications, such as the development of novel antimicrobials and vaccines, with potentially enormous impact in the biotechnology area of biomedical health and the primary industries. In addition, the project will use state-of-the-art technology, including use of synchrotron radiation at the Monash-based Australian Synchrotron facility from 2007.Read moreRead less
ARC Centre for Structural & Functional Microbial Genomics. Australian Primary Industry will benefit from a team of experts in microbial genetics, bioinformatics and protein structure and function undertaking integrated studies on microbial genomics and phenomics that are focused on fundamental biological processes and host/pathogen interactions. Whole genome expression and protein profiling will be used to characterise genes whose expression is altered in the infected host and to analyse genes i ....ARC Centre for Structural & Functional Microbial Genomics. Australian Primary Industry will benefit from a team of experts in microbial genetics, bioinformatics and protein structure and function undertaking integrated studies on microbial genomics and phenomics that are focused on fundamental biological processes and host/pathogen interactions. Whole genome expression and protein profiling will be used to characterise genes whose expression is altered in the infected host and to analyse genes involved in the control of key cellular processes. The Centre will also determine the shapes of key molecules and their interactions. Practical outcomes will include new veterinary vaccines and the identification of novel antimicrobial targets.Read moreRead less
Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restor ....Microbial community stability dynamics to environmental triggers. This project aims to advance our knowledge of the structural/functional dynamics of complex microbial communities by defining stability in response to environmental influences such as nutrient stress, pathogen invasion and antibiotics/chemicals. Using innovative microbial consortia modelling, to identify communities at risk of homeostatic disruption, we will develop and test pre-emptive microbial manipulation strategies for restoring community stability. This project will yield significant global impact and economic/health benefit for humans and animals.Read moreRead less
The cellular basis of sex-specific responses to virus infection. This project aims to explore how the sex of cells impacts virus infections in culture. To date, the sex of cells in culture has been overlooked as an important source of biological variability, but may be found to affect basic science through to anti-viral drug discovery. Using a model in which a virus can be adapted to grow better in cells of a single sex, this project expects to generate new knowledge about how sex differences im ....The cellular basis of sex-specific responses to virus infection. This project aims to explore how the sex of cells impacts virus infections in culture. To date, the sex of cells in culture has been overlooked as an important source of biological variability, but may be found to affect basic science through to anti-viral drug discovery. Using a model in which a virus can be adapted to grow better in cells of a single sex, this project expects to generate new knowledge about how sex differences impact virus-host interactions. This project expects to provide new insights into sex-based differences in how cells detect and respond to virus infection, and the extent to which the sex of cells impacts viruses in general.Read moreRead less
Virus and host genes and the outcome of infection. Viruses cause infection of all animals including people and the outcome of infection is highly variable. This project aims to use genetics to explain why some animals are more susceptible to particular virus infections and some strains of virus cause more severe diseases. The project will also explore whether all cells are similarly susceptible to killing by viruses.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238631
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of ato ....Ultra High Resolution Electron Recycling Spectrometer. Electron collisions with atoms and molecules provide enormous versatility through the transfer of large amounts of angular momentum and the ability to excite dipole forbidden states. However a lack of energy resolution severely restricts the processes that can be studied.
We propose to construct a unique, ultra-high resolution, electron recycling spectrometer using a radical new design. State-of-the-art spectroscopic studies of atoms and molecules will be enabled, including the dynamics of near-threshold processes, the formation of transient states and the examination of processes such as rotational excitation and dissociative attachment in molecules - important in a number of gas-discharge based devices.
Read moreRead less
Investigating Near-Threshold Atomic and Molecular Collision Processes with Multiparameter Detection Techniques. We are proposing to perform state-of-the-art, electron impact excitation and ionization measurements on a range of atoms and molecules. The combination of new detector technology and innovative experimental design will enable measurements of near-threshold excitation and ionization in a number of important atomic and molecular systems. The measurements will have implications for the ....Investigating Near-Threshold Atomic and Molecular Collision Processes with Multiparameter Detection Techniques. We are proposing to perform state-of-the-art, electron impact excitation and ionization measurements on a range of atoms and molecules. The combination of new detector technology and innovative experimental design will enable measurements of near-threshold excitation and ionization in a number of important atomic and molecular systems. The measurements will have implications for the further development of atomic scattering theory, particularly the role of electron-electron correlations, and provide much needed absolute scattering information on the excitation of molecules which are of relevance to our atmosphere and various technological devices.Read moreRead less
Positronic Atoms - A Search for Positron Bound States. An experimental verification of positron bound states will solve a long standing problem in positron physics. A clear understanding of positron binding and the underlying mechanisms will open a new era in low-energy positron-atom/molecular physics, leading the way for breakthrough sciences. For instance, a positron bound state should enhance the annihilation rate between the positron and target valence electron. Positron annihilation, to pro ....Positronic Atoms - A Search for Positron Bound States. An experimental verification of positron bound states will solve a long standing problem in positron physics. A clear understanding of positron binding and the underlying mechanisms will open a new era in low-energy positron-atom/molecular physics, leading the way for breakthrough sciences. For instance, a positron bound state should enhance the annihilation rate between the positron and target valence electron. Positron annihilation, to produce two gamma rays, is a key process in both materials research (e.g. as already heavily employed in defect detection) and bio-medical treatments (e.g. the Positron Emission Tomography, or PET).Read moreRead less