Liquid Biopsy For Personalised Monitoring Of Melanoma Patients
Funder
National Health and Medical Research Council
Funding Amount
$820,888.00
Summary
Despite the success of recent melanoma treatments, therapies are effective long term in only a proportion of patients. Here we will progress preliminary findings in collaboration with biotechnology and pathology companies to develop highly effective companion biomarkers that will aid treatment decisions throughout disease course. Our team will spearhead translation of these markers into the clinic for routine monitoring of melanoma patients.
Diseases caused by the pneumococcus represent the largest cause of vaccine preventable death in the world today, mainly pneumonia and meningitis. In 2011, 16 developing countries will introduce pneumococcal conjugate vaccines, none in east Asia. Lack of research has been a major barrier to their use in the region. We have established an international centre of excellence in the field and we seek support to extend the capacity of this group and to transfer the technology to Vietnam.
Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, ....Establishing advanced networks for air quality sensing and analyses. Establishing advanced networks for air quality sensing and analyses. This project aims to develop innovative, cost-effective, high resolution air quality networks. Recent developments in sensor technologies improve the ability to harvest atmospheric data. This project will develop, validate and implement methods for high sensitivity atmospheric sensing and apply cutting-edge statistical and analytic techniques to the data sets, unprecedented in scope and resolution. Outcomes include an open access database to quantify and visualise intra-urban air pollution and human exposure and develop air quality maps and smoke pollution management tools. It is expected to advance the evidence-based management of air as a resource, increasing economic prosperity and enhancing human health and quality of life.Read moreRead less
Tracking formation-flying of nanosatellites using inter-satellite links. This project aims to realise real-time kinematic precise orbit and attitude determination of nano satellites. Formation flying, based on distributed miniaturised satellites such as Cubesats, is envisioned to revolutionise the way the space-science community conducts autonomous missions. The project will develop a purely kinematic concept exploiting the full capabilities of Global Navigation Satellite Systems (GNSS) carrier- ....Tracking formation-flying of nanosatellites using inter-satellite links. This project aims to realise real-time kinematic precise orbit and attitude determination of nano satellites. Formation flying, based on distributed miniaturised satellites such as Cubesats, is envisioned to revolutionise the way the space-science community conducts autonomous missions. The project will develop a purely kinematic concept exploiting the full capabilities of Global Navigation Satellite Systems (GNSS) carrier-phase measurements for instantaneous precise orbit and attitude determination of the Cubesats. The project will also pioneer the use of the satellite based augmentation systems (SBAS), supporting the future Australian SBAS program, and the development of integrated algorithms for space-based, Precise Point Positioning with fixed ambiguities supported by SBAS.Read moreRead less
Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-spe ....Reducing glyphosate exposure from high use practices. This project aims to investigate methods of reducing occupational exposure to glyphosate, a ubiquitous pollutant of emerging concern. This will be achieved through developing new cost-effective analytical and sampling tools and refining methods for integrating human exposure (biomonitoring) data with surveillance data on the pathways of glyphosate exposure from high use. The project will generate new targeted knowledge on (sub) population-specific chemical exposures in Australia, and globally. Such data are critical to inform public health and chemical regulation policy, and provide clear guidance aimed at reducing exposures, to assess the effectiveness of existing regulations, and provide a framework for implementing surveys in the future.Read moreRead less
Fish fingerprints - signatures of oil contamination. The project aims to integrate chemical characterisation of crude oil with inorganic and organic markers in living organisms. Linking harmful effects on ecosystems with exposure to spilled crude oil remains a major challenge due to the ever-changing nature of oil in the environment. This project will expose fish to a range of fresh/weathered oils to mimic various exposure scenarios. The transition of oil to metabolites will be characterised in ....Fish fingerprints - signatures of oil contamination. The project aims to integrate chemical characterisation of crude oil with inorganic and organic markers in living organisms. Linking harmful effects on ecosystems with exposure to spilled crude oil remains a major challenge due to the ever-changing nature of oil in the environment. This project will expose fish to a range of fresh/weathered oils to mimic various exposure scenarios. The transition of oil to metabolites will be characterised in a suite of environmental and biological matrices using multi-dimensional chromatography/mass spectrometry, trace metals and compound-specific isotope analyses. This project will provide significant benefits by providing an improved capacity to link source oil with specific markers in living organisms.Read moreRead less
Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and g ....Unravelling how aquatic coastal networks regulate nitrogen removal . The aim of this project is to determine the nitrogen removal pathways of the coastal zone using a number of innovative field and modelling approaches. Little is known about how the complex coastal landscape controls trade-offs that maximise nitrogen removal but minimise nitrous oxide (a potent greenhouse gas) emissions. The outcomes of this study will significantly advance our understanding of the coastal zone in regional and global nitrogen budgets. This will provide significant benefits such as a new science-based quantitative framework to facilitate best practice management to reduce terrestrial nitrogen loads and associated downstream impacts such as eutrophication, and reduce nitrous oxide emissions and associated global warming.
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Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the c ....Airborne ultrafine particles in Australian cities. There is an acute deficiency of knowledge in Australia on urban airborne ultrafine particles, originating from transport and other anthropogenic sources, which pose significant health and environmental risks. The aim of this project is to address this deficiency by an extensive multi-city, cross-disciplinary study using state of the art instrumentation and data analytic techniques. The outcome will be an in depth, quantitative insight into the characteristics of the particles, their sources and spatial and temporal variation across different urban areas and time scales. Further, the impacts of changing fuels, vehicle technologies, and climate on future trends of the particles will be elucidated.Read moreRead less
The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecologic ....The Macroderma initiative: conserving ghost bats and informing development. This project aims to improve methods for capturing biological information required for environmental assessments of highly mobile species and enable strategic environmental planning in Northern Australia. Using Australia’s iconic ghost bat as a focus, the project will test and apply emerging technologies to obtain key information on a species’ population status and its critical resources to inform assessments of ecological impacts of industry development. Important benefits of the project include information and tools for streamlining development approvals and accurately assessing risks to threatened species to improve outcomes for both our economy and our natural environment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100146
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
The marine productivity buoy: a multi-parametric underwater profiler . The marine productivity buoy: a multi-parametric underwater profiler:
The marine productivity buoy is an innovative multi-parametric moored underwater profiler that would provide key information on phytoplankton primary productivity (PP), phytoplankton blooms, and water quality in coastal waters around Australia. The aim is to better understand changes in phytoplankton PP and abundance by synergistically using observations ....The marine productivity buoy: a multi-parametric underwater profiler . The marine productivity buoy: a multi-parametric underwater profiler:
The marine productivity buoy is an innovative multi-parametric moored underwater profiler that would provide key information on phytoplankton primary productivity (PP), phytoplankton blooms, and water quality in coastal waters around Australia. The aim is to better understand changes in phytoplankton PP and abundance by synergistically using observations from the new facility made several times a day from the surface to the seafloor, and spatially extended surface observations from Earth-orbiting ocean colour satellites. Anticipated outcomes are more accurate phytoplankton PP estimates and water quality parameters in Australian coastal waters in support to research and to monitoring of these critical environments.Read moreRead less