Prevention Of Asthma In Young Children Via Immunostimulation
Funder
National Health and Medical Research Council
Funding Amount
$679,683.00
Summary
Persistent asthma is a major problem for Australia yet none of the current therapies do more that control the condition. The long-term solution is to prevent asthma from progressing to the persistent form. The major risk factors are: family history, early allergy and recurrent severe lower respiratory infections (sLRI) in the early life. We will conduct a randomized clinical trial to prevent sLRI using a novel bacterial-derived immunostimulant in infants at high risk of developing asthma.
Gastrokine 2 Promotes Gastric Homeostasis And Inhibits Bacterial Pathology
Funder
National Health and Medical Research Council
Funding Amount
$621,335.00
Summary
Gastrokine 2 is a small regulatory protein secreted by the stomach lining. Its function is unknown but data from our lab suggests that it may be important in maintaining stomach integrity. This project will investigate how gastrokine 2 maintains stomach function, how this can be compromised when bacterial infection is ongoing, and how we might be able to turn up gastrokine 2 expression to prevent inflammation and precancerous changes in the stomach lining.
Cell Surface Mucins In Gastrointestinal Infection, Inflammation And Cancer Development
Funder
National Health and Medical Research Council
Funding Amount
$469,627.00
Summary
Cell surface mucins are protective molecules that line all the wet surface of the body, including the gastrointestinal tract. Our research has uncovered that mucins regulate cell growth and cell death. Inappropriate control by the mucins, could lead to chronic inflammation and formation of cancers. We will test how important these molecules are in the development of cancers in the intestine, and further explore the mechanism of action.
A specialised set of T lymphocytes called Mucosal Associated Invariant T (MAIT) cells react against bacteria and yeast, and reside at mucosal sites where the body's immune defences are most easily breached, e.g. respiratory tract and intestinal mucosa. This study investigates the role of MAIT cells in both protection and pathology in bacterial infections. Controlling MAIT cells could help in treating these conditions.
A Novel Therapeutic Target For Preventing Helicobacter Pylori-associated Diseases
Funder
National Health and Medical Research Council
Funding Amount
$750,336.00
Summary
Gastric cancer mainly results from chronic inflammation (gastritis) caused by the stomach-dwelling bacterium, Helicobacter pylori. We have identified a potassium channel which our data suggest could be a new therapeutic target for protecting against gastric cancer caused by H. pylori infection. This project will test the role of this channel in H. pylori gastritis and see whether drugs that target this channel can protect mice against H. pylori-associated disease.
Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
Immune Modulatory Effects Of Vaginal Microbiota Metabolites And HIV Susceptibility
Funder
National Health and Medical Research Council
Funding Amount
$795,110.00
Summary
This study will advance knowledge on how acid molecules produced by beneficial and harmful bacteria are able to promote or impede HIV infection of the female genital mucosa through their effects on the barrier and immune function of cells that line the vagina and cervix. The results of this study are anticipated to augment the efficacy of topical HIV prevention strategies and lead to the development of safe vaginal hygiene products that help protect against other sexually transmitted infections.
Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effe ....Electro-Optical Primers for Safe Use and Clean Manufacturing. Conventional primers contain a mechanically-sensitive primary explosive that is used to detonate the more stable propellant in a bullet. This project aims to address the health and environmental impacts of heavy metals in current primers by replacing them with benign, electrically or optically activated silicon-based materials. Modern semiconductor fabrication techniques will be used to develop safe and clean primers through cost-effective doping and deposition protocols. The expected outcomes of the project include a sovereign primer manufacturing capability for Australia. This will provide a significant strategic advantage and health benefits for law enforcement and defence personnel during live fire training and firing range exercises.Read moreRead less
Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection ....Civilian Protection and the Use of Force in UN Peacekeeping Operations. This project seeks to evaluate the use of force to protect civilians in United Nations peacekeeping. United Nations peacekeepers are on the frontline of efforts to protect civilians from violence. More than 100 were killed in 2014. Hundreds of thousands of civilians depend on peacekeepers for their safety. To date, however, there has been little systematic evaluation of the impact of the use of force for civilian protection mandates on both immediate protection goals and the wider goals of peacekeeping. This project aims to assess the impact of the implementation of mandates to use force to protect civilians. Through a focused comparison of six missions, it plans to identify what works, what doesn't, and the factors which determine these outcomes in order to identify ways of improving performance in the future.Read moreRead less
Sensing and Communications for Tactical Radio: Mapping the RF Weather. This project investigates sensing, localisation and communication strategies to improve the performance of modern tactical radio networks. Such networks face all of the well-known design challenges of mobile ad-hoc networks (MANETs) but with added complication of a contested and adversarial operating environment. By exploiting the power of radio nodes to sense the radio spectrum, as well as to communicate over it, a distribut ....Sensing and Communications for Tactical Radio: Mapping the RF Weather. This project investigates sensing, localisation and communication strategies to improve the performance of modern tactical radio networks. Such networks face all of the well-known design challenges of mobile ad-hoc networks (MANETs) but with added complication of a contested and adversarial operating environment. By exploiting the power of radio nodes to sense the radio spectrum, as well as to communicate over it, a distributed network of nodes can create a detailed picture of the surrounding radio-frequency (RF) environment: the nodes can work together to map the “RF weather”. In this project we will design advanced sensing and localisation methods to accurately map the RF spectrum, and then exploit this map in communication system design.Read moreRead less