Translation Of Effective Interventions In Injury Prevention And Trauma Care To A Chinese Setting
Funder
National Health and Medical Research Council
Funding Amount
$349,407.00
Summary
Evidence informed injury policy is not currently well developed in China. This research project will provide measures of the effectiveness of both a trauma care protocol in a hospital setting, and an intervention program for novice driver education-training in China, and will therefore contribute to the building of an evidence based injury prevention capacity in China.
Prognostic Factors Following A First Episode Of Central Nervous System Demyelination Suggestive Of Multiple Sclerosis.
Funder
National Health and Medical Research Council
Funding Amount
$719,475.00
Summary
Multiple sclerosis is the second most common cause of neurological morbidity in young Australians after trauma. Knowing who will progress to develop multiple sclerosis after a first attack and at what rate they will progress is an important question as it will allow us to target treatment to those at greatest risk and modify a person's lifestyle to reduce the risk of developing MS or slow their rate of progression.
EFFECT OF EBV AND HHV-6 LATENT INFECTION OR REACTIVATION ON MS ACTIVITY: A PROSPECTIVE CLINICAL COHORT STUDY
Funder
National Health and Medical Research Council
Funding Amount
$263,845.00
Summary
Multiple Sclerosis (MS) is a severely debilitating neurodegenerative disease, affecting over 16,000 Australians. There is a need to examine which factors drive the progression of this disease. We examine the role of two viral infections on MS activity. It has the potential to contribute to antiviral interventions that might prevent relapses and-or decrease the clinical progression of this debilitating disease.
Cohort Study Of Risk Factors For Young Driver Injuries
Funder
National Health and Medical Research Council
Funding Amount
$689,830.00
Summary
Injuries impose a substantial burden on young people, both in Australia and internationally. In 1998, 70% of all deaths among young men, and 57% of deaths among young women, aged 15-24 years in Australia were due to injuries. The single largest cause of injury-related fatalities, hospital admissions and emergency department presentations among this age group is transport-related incidents. Technological advances in motor vehicle engineering and road design, and the implementation of various road ....Injuries impose a substantial burden on young people, both in Australia and internationally. In 1998, 70% of all deaths among young men, and 57% of deaths among young women, aged 15-24 years in Australia were due to injuries. The single largest cause of injury-related fatalities, hospital admissions and emergency department presentations among this age group is transport-related incidents. Technological advances in motor vehicle engineering and road design, and the implementation of various road safety measures, such as random breath testing, have led to an overall decline in the incidence of motor vehicle-related injuries in Australia in the past three decades. However, young people still have substantially higher rates of motor vehicle-related mortality than older people. This suggests that if the burden of injuries among young drivers is to be reduced to levels that are at least as comparable with those in other age-groups, then the identification of factors that are specifically associated with an increased risk of motor vehicle injury among young people, must be a priority. The current study aims to determine the role of several postulated risk factors in the incidence of young driver injuries. The specific risk factors to be examined include pre-licence road and driving exposure-experience; type, quality and quantity of driver training; and road risk perceptions and engagement in sensation seeking behaviours. The study also seeks to determine whether factors associated with increased risk of driver injury are the same for different socio-economic groups and for different ethnic and cultural groups. Information obtained in this study should provide reliable evidence about causal factors for motor vehicle crash injury among young drivers. Such information should be useful to licensing and road safety professionals, in the design of practical road safety strategies aimed at reducing the burden of young driver injuries.Read moreRead less
The Role Of Past Sun Exposure, Infection History And Other Exogenous Factors In Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$92,011.00
Summary
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the brain and spinal cord that leads to various degrees of disability. The causes of MS are not yet known, and there is presently no cure. However, there is strong evidence that both an inherited susceptibility and environmental factors are important. This environmental case control study will be conducted in Tasmania and will run concurrent to a genetic project on MS which allows assessment of gene-environment interactions. ....Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the brain and spinal cord that leads to various degrees of disability. The causes of MS are not yet known, and there is presently no cure. However, there is strong evidence that both an inherited susceptibility and environmental factors are important. This environmental case control study will be conducted in Tasmania and will run concurrent to a genetic project on MS which allows assessment of gene-environment interactions. It focuses on infections, timing of childhood infections and long term sun exposure. It has been suggested that MS may be due to an immune disturbance following viral infection and that the timing of childhood infections may be initially important. Also, in Australia, there is a sevenfold increase in MS prevalence as one moves from Queensland to Tasmania. This latitudinal gradient might be due to ultra violet radiation, through an influence on immune function. Beside those main focuses, the study will include other environmental factors like chemicals, diet and vaccinations. Hopefully this project will contribute to a better understanding of the causes of MS, which are relevant for preventative strategies and devising optimal treatment.Read moreRead less