Circulating Tumour DNA Analysis Of Acquired Treatment Resistance In Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$511,807.00
Summary
Taxanes are commonly used chemotherapeutic agents in breast cancer, yet treatment resistance remains a significant clinical problem for which new approaches are needed. Many cancers shed small amounts of DNA (circulating tumor DNA (ctDNA)) into the bloodstream, and analysis of ctDNA can allow assessment of tumour specific genomic changes occurring during treatment. This project aims to utilise ctDNA to study acquired treatment resistance to taxane-based chemotherapy in metastatic breast cancer.
A Genomic Approach Towards An Understanding Of Clonal Evolution And Disease Progression In Multiple Myeloma
Funder
National Health and Medical Research Council
Funding Amount
$671,689.00
Summary
Cancer development is associated with changes in the genetic composition of the cell. These changes involve the loss/gain of genetic material and/or changes in gene expression. Using sophisticated technology, we will define the changes in the genes that are associated with the transition from a benign to a malignant cancer state. We will examine this process in the blood cancer, multiple myeloma, in order to identify new treatment targets for this incurable disease.