Stronger, coarser-grained biodegradable zinc alloys. This project aims to develop stronger and more durable zinc alloys for a new generation of biodegradable metals for potential load-bearing orthopaedic applications. It expects to deliver a group of novel zinc alloys with better properties and a new technology for manufacturing them, and to use advanced experimental techniques to reveal deformation and strengthening mechanisms that underlie the unusual Hall-Petch and anomalous twinning phenomen ....Stronger, coarser-grained biodegradable zinc alloys. This project aims to develop stronger and more durable zinc alloys for a new generation of biodegradable metals for potential load-bearing orthopaedic applications. It expects to deliver a group of novel zinc alloys with better properties and a new technology for manufacturing them, and to use advanced experimental techniques to reveal deformation and strengthening mechanisms that underlie the unusual Hall-Petch and anomalous twinning phenomena and the unprecedented properties of these alloys. Expected outcomes are likely to form the technology and scientific basis for developing better biodegradable metallic alloys. This has the potential eventually to create a better life for thousands of Australian patients.Read moreRead less
Stronger zinc alloys for more flexible biodegradable stents. This project aims to develop stronger zinc alloys for a new class of biodegradable metallic stents. A key challenge for biodegradable stent technology is to make stents as thin as possible while also being strong. This project will develop ultra-high strength zinc alloys that can be used to fabricate thinner biodegradable stents for easier surgical operation. The project outcomes should be a major step in the design and development of ....Stronger zinc alloys for more flexible biodegradable stents. This project aims to develop stronger zinc alloys for a new class of biodegradable metallic stents. A key challenge for biodegradable stent technology is to make stents as thin as possible while also being strong. This project will develop ultra-high strength zinc alloys that can be used to fabricate thinner biodegradable stents for easier surgical operation. The project outcomes should be a major step in the design and development of a new generation of biodegradable stents that will avoid the risks associated with existing products and potentially create a better life for millions of patients worldwide.Read moreRead less
Mechanics of the shape of thin strip with varying thickness. This project aims to develop an innovative technology for the production of thin strip with controlled varying longitudinal thickness and shape. The project will propose a new thin strip rolling theory and strip shape control strategy providing an improved understanding of the mechanics of manufacturing thin strips with varying longitudinal thickness. The technology to manufacture rolled products with varying thickness for lightweight ....Mechanics of the shape of thin strip with varying thickness. This project aims to develop an innovative technology for the production of thin strip with controlled varying longitudinal thickness and shape. The project will propose a new thin strip rolling theory and strip shape control strategy providing an improved understanding of the mechanics of manufacturing thin strips with varying longitudinal thickness. The technology to manufacture rolled products with varying thickness for lightweight structures is in significant demand for the automotive, aerospace and electronics industries to reduce weight through optimum strip thickness and minimum joints. The benefits will include reduced weight, fuel consumption and construction time of automobiles and aircraft when the developed novel thin strip products are used, and therefore reducing manufacturing costs and negative environmental impacts.Read moreRead less
Discovering novel allosteric probes of muscarinic acetylcholine receptors. This project aims at fostering novel approaches to selectively target vital receptors in the human body, the muscarinic acetylcholine receptors (mAChRs). By harnessing the design of receptor mutations, compounds synthesis and fluorescent imaging, the project expects to develop new pharmacological tools for a family of receptors essential for the life of all vertebrates. By enriching our understanding of this family of rec ....Discovering novel allosteric probes of muscarinic acetylcholine receptors. This project aims at fostering novel approaches to selectively target vital receptors in the human body, the muscarinic acetylcholine receptors (mAChRs). By harnessing the design of receptor mutations, compounds synthesis and fluorescent imaging, the project expects to develop new pharmacological tools for a family of receptors essential for the life of all vertebrates. By enriching our understanding of this family of receptor, the project expects to provide significant benefits to the research field by impacting on future drug discovery efforts, not only at mAChRs, but at other structurally related receptors.Read moreRead less
Net-shape micro manufacturing of composite micro channels. This project aims to develop a high precision net-shape micro manufacturing technology for the production of composite micro channels in a one-step process with excellent overall performance in quality and productivity. The new technology will enhance the production of commercial micro channels which have extensive applications in micro-electromechanical systems, health, medical and communications industries. This project will improve th ....Net-shape micro manufacturing of composite micro channels. This project aims to develop a high precision net-shape micro manufacturing technology for the production of composite micro channels in a one-step process with excellent overall performance in quality and productivity. The new technology will enhance the production of commercial micro channels which have extensive applications in micro-electromechanical systems, health, medical and communications industries. This project will improve the competitive advantage for Australia in the field of advanced manufacturing and has the potential to stimulate economic benefit and growth of the manufacturing industry.Read moreRead less
Innovative Zn alloys with essential mechanical and biofunctional properties. This project aims to develop a breakthrough understanding of the impact of alloying additions on the strengthening mechanisms, degradation behaviour, antibacterial properties and biofunctionalities of zinc alloys. The project expects to generate new knowledge in alloying strategies, plastic deformation and surface modification of zinc alloys to achieve mechanical, corrosion and biofunctional properties satisfying the re ....Innovative Zn alloys with essential mechanical and biofunctional properties. This project aims to develop a breakthrough understanding of the impact of alloying additions on the strengthening mechanisms, degradation behaviour, antibacterial properties and biofunctionalities of zinc alloys. The project expects to generate new knowledge in alloying strategies, plastic deformation and surface modification of zinc alloys to achieve mechanical, corrosion and biofunctional properties satisfying the requirements of biodegradable metallic materials. The expected outcomes are the development of novel zinc alloys and practical technologies for industry applications, such as thermomechanical processing and surface coating. The benefits are expected to extend to physical metallurgy and biomaterial manufacturing.Read moreRead less
Composite clad steel-geopolymer concrete systems for resilient structures. This project aims to develop innovative clad steel-geopolymer concrete composite members that will significantly improve the safe and economical design and construction of civil engineering systems. The expected outcomes will result in improved durability which has become a key issue in the economic justification of civil engineering infrastructure systems. Fire resistance in multi-storey buildings will also be improved t ....Composite clad steel-geopolymer concrete systems for resilient structures. This project aims to develop innovative clad steel-geopolymer concrete composite members that will significantly improve the safe and economical design and construction of civil engineering systems. The expected outcomes will result in improved durability which has become a key issue in the economic justification of civil engineering infrastructure systems. Fire resistance in multi-storey buildings will also be improved through this project, and the coupled use of clad steel and geopolymer concrete in composite systems will reduce consumption and contribute toward Net-zero structural design. This will provide considerable benefits to Australian structural engineers and constructors in advancing their capability in composite construction.Read moreRead less
Environmentally friendly lubricants for higher productivity in cold rolling. This project aims to develop an oil free aqueous lubricant for cold rolling to replace the existing oil-in-water emulsion. The lubricant will be molecularly engineered to combine synergy between nanomechanics and tribochemistry of boundary additives to deliver integrated functionalities in the strip rolling. During cold rolling , lubricant starvation often occurs at high speed and it has restricted the productivity of t ....Environmentally friendly lubricants for higher productivity in cold rolling. This project aims to develop an oil free aqueous lubricant for cold rolling to replace the existing oil-in-water emulsion. The lubricant will be molecularly engineered to combine synergy between nanomechanics and tribochemistry of boundary additives to deliver integrated functionalities in the strip rolling. During cold rolling , lubricant starvation often occurs at high speed and it has restricted the productivity of the rolling mill and affected the strip gauge and surface quality. Expected outcomes of this project include an innovative oil free lubricant with significant environmental benefits and an ability for manufacturers to improve productivity by operating at higher speeds, lower costs, and achieve superior strip surface quality.Read moreRead less
How lipid binding proteins shape the activity of nuclear hormone receptors. This project aims to explore how a family of lipid binding proteins control organ specific activation of nuclear receptors – receptors that play a key role in generating energy and are critical for life. The project will employ chemical, molecular, cell biology approaches to generate new knowledge about lipid binding protein-receptor interactions and how these complexes dictate receptor activation. The outcomes could pro ....How lipid binding proteins shape the activity of nuclear hormone receptors. This project aims to explore how a family of lipid binding proteins control organ specific activation of nuclear receptors – receptors that play a key role in generating energy and are critical for life. The project will employ chemical, molecular, cell biology approaches to generate new knowledge about lipid binding protein-receptor interactions and how these complexes dictate receptor activation. The outcomes could provide a roadmap to design drugs that interact with the right protein in the right tissue and in doing so dramatically enhance drug specificity. This will benefit the success of drug treatments which require stimulation of a therapeutic response at a target site, and avoidance of potentially toxic activity at other locations.Read moreRead less
High value biocoke for low emission steel production. This project aims to discover methods to fill nanopores that form during conversion of biomass to biocoke through controlled adsorption and carbonisation of tar compounds. By filling nanopores, their disruptive effects during coke-making will be avoided. Coke will remain a vital ingredient for steel production in the future and is currently produced from coal. The expected outcome is breakthrough knowledge to enable, for the first time, te ....High value biocoke for low emission steel production. This project aims to discover methods to fill nanopores that form during conversion of biomass to biocoke through controlled adsorption and carbonisation of tar compounds. By filling nanopores, their disruptive effects during coke-making will be avoided. Coke will remain a vital ingredient for steel production in the future and is currently produced from coal. The expected outcome is breakthrough knowledge to enable, for the first time, technologies for incorporating biomass materials into coke-making operations. Key benefits are for Australia to provide essential technologies for the world’s steel industries to lower CO2 emissions in addition to creating high value carbon products from its agricultural wastes. Read moreRead less