Sustainable copper metallurgy and recycling – saving energy and resources. This project aims to develop new, powerful and sophisticated, computer-based models that can reliably predict the results of chemical reactions in complex, high temperature metal production processes. This project expects to use these models, initially applied to copper smelting systems, to enable the improved recycling of other valuable metals. These models should be able to be applied to a wide range of technologies use ....Sustainable copper metallurgy and recycling – saving energy and resources. This project aims to develop new, powerful and sophisticated, computer-based models that can reliably predict the results of chemical reactions in complex, high temperature metal production processes. This project expects to use these models, initially applied to copper smelting systems, to enable the improved recycling of other valuable metals. These models should be able to be applied to a wide range of technologies used in the metallurgical industry as most of the world’s metals are produced by these pyrometallurgical processes. This should provide significant benefits such as substantial improvements in productivity and process efficiencies, whilst at the same time delivering energy savings and improved use of valuable metal resources.Read moreRead less
Innovative thermodynamic process control - the key to sustainable metal use. Large amounts of electronic goods such as computers and mobile phones are discarded each year in Australia. They contain both valuable and toxic metals so dumping them as landfill is unacceptable. Australia has a smelting method which could be adapted to reprocess this waste to recover the valuable metals, returning them for reuse. It would also safely handle the toxics. This project will determine the appropriate s ....Innovative thermodynamic process control - the key to sustainable metal use. Large amounts of electronic goods such as computers and mobile phones are discarded each year in Australia. They contain both valuable and toxic metals so dumping them as landfill is unacceptable. Australia has a smelting method which could be adapted to reprocess this waste to recover the valuable metals, returning them for reuse. It would also safely handle the toxics. This project will determine the appropriate smelting strategies and control methods. As a result, transportation of toxic materials overseas will be eliminated, environmental hazards will be reduced and our sustainable use of metals will be increased.Read moreRead less
Subtype selectivity and functional bias of receptor positive allosteric modulators for understanding models of pulmonary disease. G-protein-coupled receptors (GPCRs) are an important superfamily of proteins that are involved in a myriad of physiological processes and a wide range of serious illnesses. This project seeks to gain a more detailed understanding of new mechanisms of GPCR modulation and function that will be of direct relevance to drug discovery.
Structural modification of conus-derived venom peptides- A route to new therapeutics. Current product deficiencies in the area of pain management are forcing the pharmaceutical industry to develop new strategies for achieving analgesia and reduce their dependence on traditional, addictive opiate-based products. Structural modification of Conus derived peptides will provide exciting new leads for achieving effective analgesia.
Relaxin: molecular mechanisms of cardioprotection. Heart failure represents a major health and economic burden worldwide, for which there is currently no successful cure. This project will provide valuable information on the basic mechanisms associated with the vascular actions of the hormone relaxin that has shown great promise in clinical trials as a novel treatment for heart failure.
Improvements in Australia’s iron ore resource utilisation . This project aims to support improved extraction and utilisation of Australia’s iron ore resources through providing new technical information on the behaviour of the ores during iron ore sintering. The project will measure the rates of chemical reactions taking place between the minerals and high temperature melts encountered in iron ore sintering. These reactions are critical in determining the microstructures formed and the resulting ....Improvements in Australia’s iron ore resource utilisation . This project aims to support improved extraction and utilisation of Australia’s iron ore resources through providing new technical information on the behaviour of the ores during iron ore sintering. The project will measure the rates of chemical reactions taking place between the minerals and high temperature melts encountered in iron ore sintering. These reactions are critical in determining the microstructures formed and the resulting physical properties of the iron ore sinter. Understanding the effect of these properties on subsequent iron -making process efficiency will support companies to efficiently use, market, and sell different iron ores.Read moreRead less
Novel energy-efficient electrowinning anodes. Developed nations rely extensively on metallic materials to sustain modern society. This places a significant importance on delivery of base metals, and that delivery must be as efficient and clean as possible. The first step in the delivery chain is extraction from the ore, and much of this technology is based on electrowinning (EW), where the behaviour of the anode is critical to overall process efficiency. This project will deliver advances in EW ....Novel energy-efficient electrowinning anodes. Developed nations rely extensively on metallic materials to sustain modern society. This places a significant importance on delivery of base metals, and that delivery must be as efficient and clean as possible. The first step in the delivery chain is extraction from the ore, and much of this technology is based on electrowinning (EW), where the behaviour of the anode is critical to overall process efficiency. This project will deliver advances in EW anodes which will lead to energy savings, which in turn, will result in a cleaner overall production cycle, major emission reductions and cost savings. The expected outcomes of this project are targeted at the development of new and advanced anode materials.Read moreRead less
Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric ....Regulation of large artery stiffness by endothelium-derived mediators and effects on the arterial pressure waveform. Stiffening of arteries is an important cardiovascular risk factor and increases with age, high blood pressure, high cholesterol and diabetes. Cells that line the blood vessels (endothelial cells), become damaged and this reduces the available amount of a dilator substance, nitric oxide, and increases the activity of a constrictor substance, endothelin-1. We have shown that nitric oxide regulates large artery stiffness and we believe that other endothelial mediators are also important regulators. Therefore, we aim to explore this in a series of studies. Regulation of stiffness of large arteries will improve treatment of age-related cardiovascular disease (eg isolated systolic hypertension)Read moreRead less
New modulators of voltage-gated sodium channel subtypes from Australian Tarantula venoms. The venoms of Australian tarantula spiders provide a unique and untapped source of bioactive molecules. From a large stock of venom, and in collaboration with Australian pharmaceutical company Xenome, we will develop a comprehensive library of venom components suitable for drug screening. Potential national benefits from this work include a huge reduction in the healthcare bill deriving from a new treatmen ....New modulators of voltage-gated sodium channel subtypes from Australian Tarantula venoms. The venoms of Australian tarantula spiders provide a unique and untapped source of bioactive molecules. From a large stock of venom, and in collaboration with Australian pharmaceutical company Xenome, we will develop a comprehensive library of venom components suitable for drug screening. Potential national benefits from this work include a huge reduction in the healthcare bill deriving from a new treatment for pain, as well as substantial royalty returns from drugs sales. Discoveries from the program are also likely to lead to an enhancement in Australia's reputation in the neurosciences and to the development of new diagnostic research tools. The major community benefit will be a reduction in the suffering of chronic pain patients.Read moreRead less
A Novel Failure Approach for Multi-stage Aluminium Sheet Forming. This project aims to reduce waste in the production of aluminium cans. Over 200 billion aluminium beverage cans per year are produced worldwide (including 30 billion in Australia), but there is a problematic level of waste due to aluminium sheet forming failure. Current simulation of a multi-stage sheet forming process for rigid-packaging components results in a higher rejection rate due to the inaccuracy of conventional forming a ....A Novel Failure Approach for Multi-stage Aluminium Sheet Forming. This project aims to reduce waste in the production of aluminium cans. Over 200 billion aluminium beverage cans per year are produced worldwide (including 30 billion in Australia), but there is a problematic level of waste due to aluminium sheet forming failure. Current simulation of a multi-stage sheet forming process for rigid-packaging components results in a higher rejection rate due to the inaccuracy of conventional forming and fracture limit models. A novel development in this work is the design of a nonlinear strain path which is intended to maximise the forming limit of aluminium alloys and also estimate the safety margin up to the necking or fracture limit in the early die design stage.Read moreRead less