A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential ....A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential therapeutic possibilities.Read moreRead less
Novel energy-efficient electrowinning anodes. Developed nations rely extensively on metallic materials to sustain modern society. This places a significant importance on delivery of base metals, and that delivery must be as efficient and clean as possible. The first step in the delivery chain is extraction from the ore, and much of this technology is based on electrowinning (EW), where the behaviour of the anode is critical to overall process efficiency. This project will deliver advances in EW ....Novel energy-efficient electrowinning anodes. Developed nations rely extensively on metallic materials to sustain modern society. This places a significant importance on delivery of base metals, and that delivery must be as efficient and clean as possible. The first step in the delivery chain is extraction from the ore, and much of this technology is based on electrowinning (EW), where the behaviour of the anode is critical to overall process efficiency. This project will deliver advances in EW anodes which will lead to energy savings, which in turn, will result in a cleaner overall production cycle, major emission reductions and cost savings. The expected outcomes of this project are targeted at the development of new and advanced anode materials.Read moreRead less
Characterising the transport and delivery of oligonucleotides . Short RNA and DNA molecules represent a class of macromolecules that have great potential, but to facilitate their trafficking across cellular and membrane barriers into specific sites of action is challenging. This project aims to develop and apply novel imaging approaches to track them in cells and tissues. Expected outcomes include better understanding of the trafficking across cellular and membrane barriers, and improved imaging ....Characterising the transport and delivery of oligonucleotides . Short RNA and DNA molecules represent a class of macromolecules that have great potential, but to facilitate their trafficking across cellular and membrane barriers into specific sites of action is challenging. This project aims to develop and apply novel imaging approaches to track them in cells and tissues. Expected outcomes include better understanding of the trafficking across cellular and membrane barriers, and improved imaging tools that could be used to further study the molecular mechanisms of accumulation, metabolism and trafficking of these molecules. This project should provide new strategies to target these molecules to specific cells and tissues, which have significant social and economic benefits to the Australian community.Read moreRead less
Model studies of Australian lump ore applied to blast furnace ironmaking. Ore lump use in ironmaking blast furnaces (BFs) requires no preprocessing and has a lower carbon footprint. However, it suffers various technical problems. This project aims to understand and optimize the conditions for such operations. This will be achieved by means of a combined theoretical and experimental program, involving the use of state-of-the-art multiscale computer modelling and simulation techniques. The researc ....Model studies of Australian lump ore applied to blast furnace ironmaking. Ore lump use in ironmaking blast furnaces (BFs) requires no preprocessing and has a lower carbon footprint. However, it suffers various technical problems. This project aims to understand and optimize the conditions for such operations. This will be achieved by means of a combined theoretical and experimental program, involving the use of state-of-the-art multiscale computer modelling and simulation techniques. The research outcomes will be tested in the design and control of lump charging operations in practice through collaboration with the industrial partner. This will ultimately increase Australian ore lump usage in BFs, leading to significant financial and environmental benefits to Australia and the entire steel industry worldwide.Read moreRead less
Low emission iron and steelmaking using hydrogen to pre-reduce lump ore. This project aims to develop and apply a new route of lump iron ore pre-reduction with hydrogen or H2-enriched gases for ironmaking to minimise CO2 emission from steel production. The route will be built up on the base of H2 reduction kinetics of iron ore and with novel technologies such as CO2 recycle and H2-heating using hot blast, underpinning the hydrogen economy by addressing the environmental concerns in mineral and s ....Low emission iron and steelmaking using hydrogen to pre-reduce lump ore. This project aims to develop and apply a new route of lump iron ore pre-reduction with hydrogen or H2-enriched gases for ironmaking to minimise CO2 emission from steel production. The route will be built up on the base of H2 reduction kinetics of iron ore and with novel technologies such as CO2 recycle and H2-heating using hot blast, underpinning the hydrogen economy by addressing the environmental concerns in mineral and steel industries. It is not only significant for low-carbon steel production, but also for better fundamental understanding to develop the future zero-emission iron and steelmaking with hydrogen. The project will be very beneficent because it increases the use of lump iron ore and expends Australian export of iron ores.Read moreRead less
Improved control of dioxin emissions during iron ore sintering. This project aims to develop an innovative assessment of dioxin formation through analysis and speciation of its precursors (Cl and Cu). Iron ore sintering is the industrial process with the highest emissions of dioxins and furans to the environment in Australia, which are amongst the most toxic substances produced by man. The aim of this project is to conduct critical investigations required for control of dioxin emissions during i ....Improved control of dioxin emissions during iron ore sintering. This project aims to develop an innovative assessment of dioxin formation through analysis and speciation of its precursors (Cl and Cu). Iron ore sintering is the industrial process with the highest emissions of dioxins and furans to the environment in Australia, which are amongst the most toxic substances produced by man. The aim of this project is to conduct critical investigations required for control of dioxin emissions during iron ore sintering. The expected outcome of this project is the development of control mechanisms for the process conditions responsible for dioxin formation. This should provide significant benefits, such as assisting the Australian iron ore industry to address the environmental requirements of their international trade partners and sustain their iron ore exports.Read moreRead less