Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Modelling of particle-fluid reactive flows coupled with phase changes. This project aims to develop an integrated mathematical model for reliably describing multiphase reactive flow coupled with phase change. Particle-fluid reactive flows with phase changes are widely encountered in many energy-intensive industries, yet process design and optimization are hindered by the lack of understanding of complex phenomena governing particularly multiphase flow, phase change and their interactions. The m ....Modelling of particle-fluid reactive flows coupled with phase changes. This project aims to develop an integrated mathematical model for reliably describing multiphase reactive flow coupled with phase change. Particle-fluid reactive flows with phase changes are widely encountered in many energy-intensive industries, yet process design and optimization are hindered by the lack of understanding of complex phenomena governing particularly multiphase flow, phase change and their interactions. The model will be achieved by means of combining advanced particle-scale numerical techniques with pre-database-based thermodynamic model, supported by physical experiments. The outcomes will be applied across a range of industries of vital importance to Australian economic and technological future. It will help transform Australian pyrometallurgy and chemical industries, open new markets for a range of Australian minerals like low-grade coal and iron/copper ore, and ultimately enhance competitiveness of Australian economy.Read moreRead less
Future polymetallic processing through lead smelting, recycling, refining. The aim of the project is to provide new data and thermodynamic modelling tools to be used in the development of the next generation of lead metal smelting, refining and recycling processes used to recycle electronic materials, process hazardous wastes and recover valuable metals. The intention is to combine recently developed experimental techniques with the latest advances in FactSage chemical thermodynamic modelling to ....Future polymetallic processing through lead smelting, recycling, refining. The aim of the project is to provide new data and thermodynamic modelling tools to be used in the development of the next generation of lead metal smelting, refining and recycling processes used to recycle electronic materials, process hazardous wastes and recover valuable metals. The intention is to combine recently developed experimental techniques with the latest advances in FactSage chemical thermodynamic modelling to overcome long-standing experimental and modelling obstacles. The new experimental data and databases are intended to provide important information on high-temperature chemistry of complex phase equilibria and on the distribution of minor elements in multiphase systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100165
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Thermal and mechanical simulation laboratory for light metals. The creation of a thermal and mechanical simulation laboratory for light metals will provide the critical infrastructure needed for generating new alloys and composites. This will extend Australia's competitive advantage in the design of better alloys for expanding applications in the construction, packaging, automotive and aerospace sectors.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100115
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Facility for the development of new lightweight extruded alloys and structures. This will be Australia's only large-scale, research-dedicated extrusion facility. It is expected to lead to the development of new light metal alloys, metal-matrix composites, micro-truss structures and powder base metals for structural and biomedical applications.
Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle ....Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle and adipose tissue by stimulating the movement of a glucose transport protein from inside the cell to the cell surface (see http:--www.imb.uq.edu.au-groups-james-glut4 for an animated description of this process). The purpose of this proposal is to dissect the molecular mechanisms by which this glucose transporter can be held inside the cell in the absence of insulin and then allowed to be released from this site moving to the surface in the presence of insulin. Our studies over the past 5 years have brought us much closer to understanding this process in detail. The identification of the molecules responsible for this regulatory step will not only aid our understanding of this process but it will also provide a valuable target for development of therapeutic agents that can be used to combat insulin resistance.Read moreRead less
The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with res ....The MYB gene as a model for global transcriptional regulation: stopping, starting and looping. This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.Read moreRead less