Future polymetallic processing through lead smelting, recycling, refining. The aim of the project is to provide new data and thermodynamic modelling tools to be used in the development of the next generation of lead metal smelting, refining and recycling processes used to recycle electronic materials, process hazardous wastes and recover valuable metals. The intention is to combine recently developed experimental techniques with the latest advances in FactSage chemical thermodynamic modelling to ....Future polymetallic processing through lead smelting, recycling, refining. The aim of the project is to provide new data and thermodynamic modelling tools to be used in the development of the next generation of lead metal smelting, refining and recycling processes used to recycle electronic materials, process hazardous wastes and recover valuable metals. The intention is to combine recently developed experimental techniques with the latest advances in FactSage chemical thermodynamic modelling to overcome long-standing experimental and modelling obstacles. The new experimental data and databases are intended to provide important information on high-temperature chemistry of complex phase equilibria and on the distribution of minor elements in multiphase systems.Read moreRead less
Coke integrity in blast furnace ironmaking: understanding and technology development. This project's expected outcomes will lead to optimised coke consumption for the blast furnace and to a more competitive steel manufacturing sector, through improved and rational criteria for selection of carbonaceous materials. This will result in more efficient ironmaking with significant operational, economical and environmental benefits.
The use of Australian magnetite ore in advanced ironmaking. The project will study reduction behaviour of Australian magnetite ore in advanced ironmaking with low emission of greenhouse and hazardous substances. Efficient utilisation of magnetite ore which economic demonstrated resources constitute 9.5 gigatonnes will be of high importance to Australian industry and prosperity.
Microstructure control of hot-dip coated Al-Zn based alloy layers on steel . The process of hot-dip metal coating of steel has evolved to provide reliable products that find widespread application in many industries, including building and construction. This project aims to address and understand an intermittent processing problem using innovative approaches involving characterisation by synchrotron techniques and state-of-the art microscopy. Expected outcomes include increased manufacturing e ....Microstructure control of hot-dip coated Al-Zn based alloy layers on steel . The process of hot-dip metal coating of steel has evolved to provide reliable products that find widespread application in many industries, including building and construction. This project aims to address and understand an intermittent processing problem using innovative approaches involving characterisation by synchrotron techniques and state-of-the art microscopy. Expected outcomes include increased manufacturing efficiencies by identifying the cause of an intermittent processing defect and implementing methods of controlling this defect. This will help BlueScope and Australia maintain a world-leading reputation for high-quality coating products for domestic and export markets.Read moreRead less
Innovation for anchorage wedge manufacturing. The consumption of tendon anchorage wedges worldwide is in the billions every year, but their manufacturing process is inadequate. The revolutionary technology to be developed by this proposed research will enable the manufacturers to achieve a cost-effective eco-fabrication with minimal material and energy wastages.
Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on chall ....Determination of the mechanisms of immune system regulation of inflammation by the human protein, chaperonin 10. The aim of this project is to determine the mechanisms by which a human protein, chaperonin 10 (Cpn10), regulates the immune system and suppresses inflammation. When cells of the human immune system are challenged with lipopolysaccharide (LPS) (a product of bacterial infection), the pro-inflammatory cytokine TNF is released. Cpn10 has been shown to suppress production of TNF on challenge of cells with LPS, while increasing the levels of the anti-inflammatory cytokine IL-10. Investigating the role of Cpn10 in modulating inflammation will contribute to the understanding and treatment of diseases associated with inflammation, including multiple sclerosis and rheumatoid arthritis.Read moreRead less
NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoi ....NOVEL THERAPEUTICS FOR AUTOIMMUNE DISEASE USING MOUSE SCREENING MODELS. The project aims to use experimental models of human autoimmune disease in the mouse for the testing of developmental isoflavonoid compounds produced by the Industry Partner, for protective effects against autoimmunity. The murine models proposed will duplicate human autoimmune cardiomyopathy, systemic lupus erythematosus and multiple sclerosis, encompassing both organ-specific and systemic autoimmune diseases. Isoflavonoid protection is anticipated from the antioxidant, anti-inflammatory and oestrogenic characteristics of these compounds/Read moreRead less
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less
Targeted development of dual action antitumour and antiangiogenic agents using differential and functional proteomics. There is an enormous need to develop more effective and less toxic therapeutic approaches to reduce the social and economic burden of cancer. The recent identification of small molecules that can act by both destroying cancer cells and the blood vessels that carry nutrients to them has provided a unique opportunity to define the pathways involved in the action of these agents in ....Targeted development of dual action antitumour and antiangiogenic agents using differential and functional proteomics. There is an enormous need to develop more effective and less toxic therapeutic approaches to reduce the social and economic burden of cancer. The recent identification of small molecules that can act by both destroying cancer cells and the blood vessels that carry nutrients to them has provided a unique opportunity to define the pathways involved in the action of these agents in order to develop more potent drug analogues. Development of these molecules will involve a collaborative and multidisciplinary link with our industry partner and the use of frontier technologies that may lead to improved health and economic outcomes for Australia. Read moreRead less
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less