Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
New targets for antiviral therapies. The ability of dangerous viruses to cause lethal disease depends on their capacity to evade the immune system of infected hosts. This project will uncover at the molecular level the strategies used by viruses to disable immune responses; this will identify new ways to treat incurable diseases, by disabling the virus' defences against the immune system.
Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preven ....Examination of the Calcium Signalling Dynamics Linked to Integrin Adhesion Utilising a Novel Micro-imaging System. This study aims at increasing our understanding of the fundamental cell processes that allow cells to adhere to surfaces. The proposed study will lead to a greater understanding of the calcium signalling mechanisms that are fundamental to diverse biological phenomena such as, tissue regeneration and repair, blood clotting, cancer metastasis, and neuronal cell function. From a preventative health perspective, the investigation of platelet calcium signalling will greatly accelerate the development of new pharmaceuticals to tackle acute and chronic cardiovascular diseases, such as stroke, heart attack and artherosclerosis. Read moreRead less
High performance cast magnesium alloys. Reducing the weight of cars, particularly their engines, enables substantial reductions in fuel consumption and greenhouse gas emissions. A new generation of magnesium alloys will be developed by this project for the manufacture of considerably lighter components with improved mechanical performance for powertrain and structural applications.
Composition, assembly and functions of the pellicle of apicomplexan parasites: a structure pivotal to disease transmission and progression. Apicomplexan parasites are successful agents of disease (e.g. malaria) due to their superb ability to quickly invade host cells and generate many more parasites. This project will study the dedicated structures beneath the parasite cell covering that are responsible for these abilities to help refine strategies for combating apicomplexan diseases.
Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unp ....Origin and impact of solute clustering in light alloys. This project is designed to provide a physical metallurgy platform for understanding and interpreting the role of clusters of micro-alloying elements in precipitation in light alloys and aiding new alloy development. Phase transformations play an important role in determining the mechanical properties of many engineering materials. Understanding the origin and impact of solute clustering in phase transformations is crucial for achieving unprecedented properties in these materials. This project plans to combine atomic-scale characterisation and multi-scale computation to reveal the geometry and energetics of solute clusters and cluster-assisted nucleation in light alloys based on aluminium and magnesium. Applications may include the development of stronger and less costly metallic materials for the aerospace, aircraft and automotive industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100071
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capabil ....In-situ elevated temperature nano-indentation. In-situ elevated temperature nano-indentation: Nano-indentation has revolutionised the characterisation of the mechanical properties of materials. It permits the elastic, plastic and cracking response to be probed at the nano-scale. This project will provide a state-of-the-art Hysitron nano-indenter configured to permit isothermal elevated temperature operation (up to 650 degrees Celsius). The unit will be the only one in Australia with this capability and amongst the few available globally. Temperature is the single most important parameter in material processing. This facility will permit the assembled team to be among the first in the world to apply this technique to the development of new materials with superior processing performance in addition to enhanced behaviour in service.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100087
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
Enabling future technology by building light element analysis capability: a light element optimised ultra-high resolution electron microprobe. The capability to characterise the chemistry of materials at very small scales is critical for geologists, metallurgists and materials scientists. The new instrument is world-leading technology that will enable analysis of light element-rich materials at extremely high resolution (< 50 nanometers) with very low detection limits.