Genotypes And Phenotypes Of Human Primary Non-congenital Antibody Deficiency
Funder
National Health and Medical Research Council
Funding Amount
$544,692.00
Summary
Antibodies represent a key component of the immune system, and a particularly important in defence against bacterial and viral infections. In some individuals, antibody production fails, rendering them more susceptible to infection. In most cases, the mechanism of antibody failure is unknown. This project seeks to determine the genetic and cellular mechanisms of antibody failure. This could improve diagnosis for immune deficiency, and improve our overall understanding of the immune system.
Humanisation And Pre-clinical Validation Of A Therapeutic Anti-cancer Antibody
Funder
National Health and Medical Research Council
Funding Amount
$699,136.00
Summary
This grant will develop a novel antibody against a protease expressed on cancer cells. Preclinical studies, and antibody humanisation, will be performed. This project will also provide vital information on optimal therapeutic approaches with the antibody that can be ultimately taken into human trials.
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Investigating B Cell Development, Maintenance And High-affinity Antibody Production By ENU Mutagenesis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Discovery Early Career Researcher Award - Grant ID: DE190101389
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Imaging, analysing and forecasting Australian hazards with satellites. This project aims to improve Australia’s ability to anticipate geophysical hazards. It will generate a new national capability in the use of satellite radar imagery to monitor and manage geohazards, benefiting all communities. By producing high-resolution maps of ground displacements, the project will assess the controls upon where and why these events occur, and whether they exhibit precursory behaviour. This is the first st ....Imaging, analysing and forecasting Australian hazards with satellites. This project aims to improve Australia’s ability to anticipate geophysical hazards. It will generate a new national capability in the use of satellite radar imagery to monitor and manage geohazards, benefiting all communities. By producing high-resolution maps of ground displacements, the project will assess the controls upon where and why these events occur, and whether they exhibit precursory behaviour. This is the first step towards accurate hazard forecasting and in building Australia's capability for near-real-time geophysical hazard monitoring on a national scale. The outputs will impact upon future recommendations for national earthquake and landslide monitoring and deliver new tools to underpin regulation of resource extraction and inform construction codes.Read moreRead less
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100062
Funder
Australian Research Council
Funding Amount
$404,000.00
Summary
What's shaking down under? This project aims to determine the underlying cause of recent earthquake activity in central Australia. Of all the stable continents, Australia is surprisingly seismically active, with intra-plate earthquakes occurring relatively frequently. However, these are unpredictable, placing lives and infrastructure at risk. This project offers the opportunity to use a new seismic experiment to improve detection of small events that may warn of a more dangerous earthquake to co ....What's shaking down under? This project aims to determine the underlying cause of recent earthquake activity in central Australia. Of all the stable continents, Australia is surprisingly seismically active, with intra-plate earthquakes occurring relatively frequently. However, these are unpredictable, placing lives and infrastructure at risk. This project offers the opportunity to use a new seismic experiment to improve detection of small events that may warn of a more dangerous earthquake to come, and provide sub-surface imaging of the hidden crustal boundaries and faults that are ultimately responsible. Benefits will include improved hazard assessment, and a new predictive model for exploration that relates regional seismicity, crustal faults, and mineral systems.Read moreRead less