Immuno-polymeric Drugs For Prostate Cancer Therapy
Funder
National Health and Medical Research Council
Funding Amount
$626,995.00
Summary
Prostate cancer is the most common cancer in men over 50 and the second most frequent cause of cancer deaths in Western society. Docetaxel is the first line of chemotherapy when other intervention strategies are unsuccessful, but 30% of patients suffer from severe side-effects. To address this problem, we will utilise carriers for docetaxel that directly target prostate tumours using a novel antibody approach. This increases accumulation at the tumour site while decreasing off-target toxicity.
Optimising artificial reef structures for nature-based coastal protection . This project aims to develop a novel framework for predicting how artificial reef structures can be optimally designed to protect coastlines from erosion and flooding. It will develop new theory and models to quantify how waves interact with complex reef structures to reduce wave heights and extreme water levels at the shoreline. Expected outcomes include new practical tools and design guidelines that can be adopted by c ....Optimising artificial reef structures for nature-based coastal protection . This project aims to develop a novel framework for predicting how artificial reef structures can be optimally designed to protect coastlines from erosion and flooding. It will develop new theory and models to quantify how waves interact with complex reef structures to reduce wave heights and extreme water levels at the shoreline. Expected outcomes include new practical tools and design guidelines that can be adopted by coastal engineers and managers to maximise coastal protection by reefs. This will boost Australia’s capacity to protect populations and critical infrastructure from coastal hazards and support Australian industries to lead the international development of innovative nature-based coastal protection strategies.Read moreRead less
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
Food System Shocks: Managing Transitions to Future Food Security. Recent food system shocks such as bushfires, floods, drought, and the impact of Covid-19 on the harvesting and distribution of agricultural products, are having profound on-farm impacts. Farmers, as land managers, are on the front line of navigating these major disruptions whilst also maintaining continuity of supply that supports Australia's national and regional food security. Situating the farmer as the 'expert' of managing and ....Food System Shocks: Managing Transitions to Future Food Security. Recent food system shocks such as bushfires, floods, drought, and the impact of Covid-19 on the harvesting and distribution of agricultural products, are having profound on-farm impacts. Farmers, as land managers, are on the front line of navigating these major disruptions whilst also maintaining continuity of supply that supports Australia's national and regional food security. Situating the farmer as the 'expert' of managing and accommodating shocks, this project will co-produce a range of evidence-based transition and innovation scenarios for the horticultural industry to enhance future preparedness for shocks and support rural livelihoods. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101361
Funder
Australian Research Council
Funding Amount
$403,866.00
Summary
The Australian tectonic stress state: Far-field forces and local impacts. This project aims to investigate the present-day tectonic stress field of Australia using detailed analysis of stress magnitude data and state-of-the-art 3D geomechanical-numerical modelling across spatial scales. Tectonic stresses control the Earth’s deformation and are a primary cause of collapse of subsurface structures. This project expects to improve our knowledge of the causes of the tectonic stress field of Australi ....The Australian tectonic stress state: Far-field forces and local impacts. This project aims to investigate the present-day tectonic stress field of Australia using detailed analysis of stress magnitude data and state-of-the-art 3D geomechanical-numerical modelling across spatial scales. Tectonic stresses control the Earth’s deformation and are a primary cause of collapse of subsurface structures. This project expects to improve our knowledge of the causes of the tectonic stress field of Australia and its consequences for earthquake risk assessment, safe and sustainable usage of underground environments for groundwater exploration and production, CO2 sequestration, waste disposal, mine stability, exploration and production of hydrocarbon and geothermal resources.Read moreRead less
Ion Channel Dysfunction In The Pathophysiology Of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: Diagnostic Biomarkers, Therapeutic Targets And Treatments
Funder
National Health and Medical Research Council
Funding Amount
$1,460,700.00
Summary
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an illness affecting up to 240,000 Australians. The cause of ME/CFS is not known, and there are currently no diagnostic tests or effective treatments. Research suggests that ion channels that transfer calcium within cells are dysfunctional in ME/CFS. Our research will investigate ion channels and calcium transfer using immune cells to help develop biomarkers for the illness and discover better treatments for these patients.
Impact of Native Title on Local Government in Australia. This project will consider in detail the Integrated Planning Act 1997 (Qld) (IPA) and how the implementation IPA Planning Schemes will impact upon native title rights to land and sea. The project will also look at the impact of IPA on development applications made by native titleholders themselves. It will provide for identification and analysis of the relevant legal arrangements affecting native title, and the creation for taxonomy of imp ....Impact of Native Title on Local Government in Australia. This project will consider in detail the Integrated Planning Act 1997 (Qld) (IPA) and how the implementation IPA Planning Schemes will impact upon native title rights to land and sea. The project will also look at the impact of IPA on development applications made by native titleholders themselves. It will provide for identification and analysis of the relevant legal arrangements affecting native title, and the creation for taxonomy of impacts arising out of the interaction of the two legal regimes. The project will indicate strategies to facilitate cooperation between local planning authorities and indigenous stakeholders within existing legal structures.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100090
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Coastal Engineering Research Field Station (CERFS). This project aims to establish a Coastal Engineering Research Field Station (CERFS) with instrument modules for measuring waves, tides, currents, seabed and beach profiles and sediment characteristics. There are critical knowledge gaps in the understanding of coastal processes, including the effects of climate variability and change, and a need to generate long-term data-sets for calibration of coastal models against Australian conditions. The ....Coastal Engineering Research Field Station (CERFS). This project aims to establish a Coastal Engineering Research Field Station (CERFS) with instrument modules for measuring waves, tides, currents, seabed and beach profiles and sediment characteristics. There are critical knowledge gaps in the understanding of coastal processes, including the effects of climate variability and change, and a need to generate long-term data-sets for calibration of coastal models against Australian conditions. The coastal process data obtained will lead to improved models, management strategies and design guidelines improving techniques to address coastal infrastructure design, beach management strategies and impact assessment to meet the challenges of future major coastal development. This will help decision-makers to reduce the risk to coastal communities, coastal ecosystems and maritime operations from extreme storms, climate change, infrastructure development and urbanisation.Read moreRead less