Inhibition Of Cellcell Actin-based Motility During Poxvirus Infection By The Kinase Inhibitor Glivec
Funder
National Health and Medical Research Council
Funding Amount
$92,950.00
Summary
Although smallpox, one of the deadliest human pathogens, was eradicated in 1980, the current global climate has resulted in fears that smallpox may be used as a biological weapon. Unfortunately the smallpox vaccine poses a serious health hazard to certain people. We have shown that Glivec, a drug used to treat cancer, has potent anti-viral affects on poxvirus replication. This project will test the effectiveness of Glivec in treating smallpox in an animal model and study how it acts.
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge ....Fragmentation of rocks upon impact. The project aims to create a new understanding of how rocks fragment upon impact to allow more realistic predictions of rockfall hazards. Rockfall results in loss of human life, damage to infrastructure and economic loss; each year in Australia, millions of dollars are spent on rockfall protection. To mitigate rockfall risk, it is important to understand and predict how blocks break as they fall down a slope. Unfortunately, there is limited data and knowledge on this phenomenon. This project aims to produce a comprehensive, high-quality database of fragmentation events and develop an innovative fragmentation model that can be included in existing rockfall codes. This project is expected to lead to optimised and cost-effective rockfall barrier protection measures.Read moreRead less
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
An Australian storm wave damage and beach erosion early warning system. This project aims to develop a new coastal hazard early-warning system capability for Australia, to alert coastal communities, emergency managers and coastal engineers to impending storm wave damage and coastal erosion. Emergency preparedness informed by early warning is expected to significantly benefit vulnerable communities and infrastructure along Australia’s coasts.
What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dy ....What is killing the honeybees? The role of RNA viruses. This project aims to determine if the Varroa mite, the most important parasite of honeybees, selects for virulent strains of RNA viruses. Before Varroa’s inevitable arrival in Australia, this project will disentangle the effect of Varroa and the bees’ immune system on the evolution of virulence of bee viruses. Australia’s honeybees are Varroa-naïve and don’t carry virulent viruses. There is a known association between Varroa and colonies dying from viruses; however, it is not known what is cause and effect. This project will clarify Varroa’s exact role in the evolution of virulence in RNA viruses. The intended outcome is increased knowledge allowing the design of an effective treatment to prevent the death of honeybee colonies.Read moreRead less
Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by r ....Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by replacing the current practice of managing river basins separately, with a framework that accounts for among-basin linkages that are essential for the long-term persistence of fish populations. Significant benefits include more efficient use of water resources and improved conservation outcomes for native fish.Read moreRead less
The effective strength of oceanic plate bounding faults. This project will address the anomalously weak behaviour of the seismically active faults on the boundary of the Australian plate, in three key geodynamic areas. This will constrain the mechanisms which weaken such faults, and produce a model for their effective strength and evolution over geological timescales.
Investigation of atypical bushfire spread driven by the interaction of wind, terrain and fire. Large bushfires continue to pose a significant risk to communities in south-eastern Australia. Despite this, there is still very little known about the processes driving the development of large bushfires. This project aims to improve understanding of extreme fire processes and thus improve mitigation planning, community safety and environmental outcomes.