How Does NF-kB2 Regulate Thymic Selection To Prevent Organ-specific Autoimmune Disease?
Funder
National Health and Medical Research Council
Funding Amount
$787,600.00
Summary
Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
Discovery Early Career Researcher Award - Grant ID: DE190101389
Funder
Australian Research Council
Funding Amount
$325,000.00
Summary
Imaging, analysing and forecasting Australian hazards with satellites. This project aims to improve Australia’s ability to anticipate geophysical hazards. It will generate a new national capability in the use of satellite radar imagery to monitor and manage geohazards, benefiting all communities. By producing high-resolution maps of ground displacements, the project will assess the controls upon where and why these events occur, and whether they exhibit precursory behaviour. This is the first st ....Imaging, analysing and forecasting Australian hazards with satellites. This project aims to improve Australia’s ability to anticipate geophysical hazards. It will generate a new national capability in the use of satellite radar imagery to monitor and manage geohazards, benefiting all communities. By producing high-resolution maps of ground displacements, the project will assess the controls upon where and why these events occur, and whether they exhibit precursory behaviour. This is the first step towards accurate hazard forecasting and in building Australia's capability for near-real-time geophysical hazard monitoring on a national scale. The outputs will impact upon future recommendations for national earthquake and landslide monitoring and deliver new tools to underpin regulation of resource extraction and inform construction codes.Read moreRead less
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100062
Funder
Australian Research Council
Funding Amount
$404,000.00
Summary
What's shaking down under? This project aims to determine the underlying cause of recent earthquake activity in central Australia. Of all the stable continents, Australia is surprisingly seismically active, with intra-plate earthquakes occurring relatively frequently. However, these are unpredictable, placing lives and infrastructure at risk. This project offers the opportunity to use a new seismic experiment to improve detection of small events that may warn of a more dangerous earthquake to co ....What's shaking down under? This project aims to determine the underlying cause of recent earthquake activity in central Australia. Of all the stable continents, Australia is surprisingly seismically active, with intra-plate earthquakes occurring relatively frequently. However, these are unpredictable, placing lives and infrastructure at risk. This project offers the opportunity to use a new seismic experiment to improve detection of small events that may warn of a more dangerous earthquake to come, and provide sub-surface imaging of the hidden crustal boundaries and faults that are ultimately responsible. Benefits will include improved hazard assessment, and a new predictive model for exploration that relates regional seismicity, crustal faults, and mineral systems.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100040
Funder
Australian Research Council
Funding Amount
$337,300.00
Summary
Enabling next-generation earthquake and tsunami early warning. This project aims to develop a new approach for earthquake and tsunami early warning, avoiding many of the limitations currently present in such systems. The project will combine machine learning and artificial intelligence with state-of-the-art geophysical modelling, allowing high-quality real-time prediction of seismic hazards with full uncertainty information. Highlighting opportunities at the interface between geoscience and data ....Enabling next-generation earthquake and tsunami early warning. This project aims to develop a new approach for earthquake and tsunami early warning, avoiding many of the limitations currently present in such systems. The project will combine machine learning and artificial intelligence with state-of-the-art geophysical modelling, allowing high-quality real-time prediction of seismic hazards with full uncertainty information. Highlighting opportunities at the interface between geoscience and data science, the project will stimulate novel approaches, and build Australian research capacity in this area. Expected benefits include improved techniques for geophysical imaging and real-time data analysis, in addition to enhanced capabilities for mitigating the costs associated with seismic activity.Read moreRead less
New observational constraints on 2004-2007 rupture of the Sumatra megathrust. This project will develop innovative methods and generate new data for studying the rupture of giant subduction zone earthquakes and the generation of destructive tsunamis. This will lead to a better understanding of these phenomena that will enhance our ability to forecast, warn and map the hazards associated with them.
Earthquake hazard in Indonesia. This project will deliver breakthrough science that will strengthen Indonesia's ability to reduce its vulnerability to earthquake disasters. This will be achieved through a collaboration of Australian and Indonesian scientists who will fundamentally improve understanding of the destructive potential of Indonesian earthquakes.
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Regulatory design for water quality management in urban catchments. This project aims, through empirical research (i) to evaluate the effectiveness of current regulatory, quasi-regulatory and other policy strategies for water quality management in urban catchments (including total/integrated catchment management); (ii) to provide practical policy prescriptions concerning how through judicious regulatory and institutional design, those problems may be best addressed for the future; and (iii) adva ....Regulatory design for water quality management in urban catchments. This project aims, through empirical research (i) to evaluate the effectiveness of current regulatory, quasi-regulatory and other policy strategies for water quality management in urban catchments (including total/integrated catchment management); (ii) to provide practical policy prescriptions concerning how through judicious regulatory and institutional design, those problems may be best addressed for the future; and (iii) advance regulatory theory by developing a framework for understanding the relative effectiveness of different regulatory regimes in the context of urban catchment management. Its empirical focus is on the Swan-Canning river in Western Australia.Read moreRead less