Ion Channel Dysfunction In The Pathophysiology Of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome: Diagnostic Biomarkers, Therapeutic Targets And Treatments
Funder
National Health and Medical Research Council
Funding Amount
$1,460,700.00
Summary
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an illness affecting up to 240,000 Australians. The cause of ME/CFS is not known, and there are currently no diagnostic tests or effective treatments. Research suggests that ion channels that transfer calcium within cells are dysfunctional in ME/CFS. Our research will investigate ion channels and calcium transfer using immune cells to help develop biomarkers for the illness and discover better treatments for these patients.
Mid-Career Industry Fellowships - Grant ID: IM230100154
Funder
Australian Research Council
Funding Amount
$1,049,904.00
Summary
Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produ ....Fungi Power: Designer Fungal Cell Factories for Advanced Biomanufacturing. This project aims to build an advanced biomanufacturing platform based on filamentous fungi in collaboration with industry. Using synthetic biology, the project expects to engineer superior fungal host strains customisable to the needs of the industry and to address their technological gaps. The expected outcomes include the development of cost-efficient and sustainable fungal-based bioprocesses for the companies to produce products, such as fine chemicals, pharmaceutical actives and food ingredients. The project would provide significant benefits by enabling existing and emerging companies' commercial successes and competitiveness in global markets, creating new jobs and resulting in the growth of the bio-economy in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100784
Funder
Australian Research Council
Funding Amount
$373,254.00
Summary
Molecular probe development for the oxytocin and vasopressin receptors. The oxytocin and vasopressin receptors are part of a 600 million year old signalling system that is widely distributed in the kingdom of life. It is involved in many fundamental physiological functions, however we still lack a complete toolbox of selective probes to delineate the individual receptor subtypes. This project aims to introduce a novel and innovative strategy that uses state-of-the art discovery techniques to ide ....Molecular probe development for the oxytocin and vasopressin receptors. The oxytocin and vasopressin receptors are part of a 600 million year old signalling system that is widely distributed in the kingdom of life. It is involved in many fundamental physiological functions, however we still lack a complete toolbox of selective probes to delineate the individual receptor subtypes. This project aims to introduce a novel and innovative strategy that uses state-of-the art discovery techniques to identify selective ligands in nature. Leads will be developed into molecular probes to facilitate in-depth studies of this system. This strategy is applicable to other systems and the outcomes will contribute to a significant advancement of knowledge in chemical biology.Read moreRead less
Optimising artificial reef structures for nature-based coastal protection . This project aims to develop a novel framework for predicting how artificial reef structures can be optimally designed to protect coastlines from erosion and flooding. It will develop new theory and models to quantify how waves interact with complex reef structures to reduce wave heights and extreme water levels at the shoreline. Expected outcomes include new practical tools and design guidelines that can be adopted by c ....Optimising artificial reef structures for nature-based coastal protection . This project aims to develop a novel framework for predicting how artificial reef structures can be optimally designed to protect coastlines from erosion and flooding. It will develop new theory and models to quantify how waves interact with complex reef structures to reduce wave heights and extreme water levels at the shoreline. Expected outcomes include new practical tools and design guidelines that can be adopted by coastal engineers and managers to maximise coastal protection by reefs. This will boost Australia’s capacity to protect populations and critical infrastructure from coastal hazards and support Australian industries to lead the international development of innovative nature-based coastal protection strategies.Read moreRead less
Food System Shocks: Managing Transitions to Future Food Security. Recent food system shocks such as bushfires, floods, drought, and the impact of Covid-19 on the harvesting and distribution of agricultural products, are having profound on-farm impacts. Farmers, as land managers, are on the front line of navigating these major disruptions whilst also maintaining continuity of supply that supports Australia's national and regional food security. Situating the farmer as the 'expert' of managing and ....Food System Shocks: Managing Transitions to Future Food Security. Recent food system shocks such as bushfires, floods, drought, and the impact of Covid-19 on the harvesting and distribution of agricultural products, are having profound on-farm impacts. Farmers, as land managers, are on the front line of navigating these major disruptions whilst also maintaining continuity of supply that supports Australia's national and regional food security. Situating the farmer as the 'expert' of managing and accommodating shocks, this project will co-produce a range of evidence-based transition and innovation scenarios for the horticultural industry to enhance future preparedness for shocks and support rural livelihoods. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101361
Funder
Australian Research Council
Funding Amount
$403,866.00
Summary
The Australian tectonic stress state: Far-field forces and local impacts. This project aims to investigate the present-day tectonic stress field of Australia using detailed analysis of stress magnitude data and state-of-the-art 3D geomechanical-numerical modelling across spatial scales. Tectonic stresses control the Earth’s deformation and are a primary cause of collapse of subsurface structures. This project expects to improve our knowledge of the causes of the tectonic stress field of Australi ....The Australian tectonic stress state: Far-field forces and local impacts. This project aims to investigate the present-day tectonic stress field of Australia using detailed analysis of stress magnitude data and state-of-the-art 3D geomechanical-numerical modelling across spatial scales. Tectonic stresses control the Earth’s deformation and are a primary cause of collapse of subsurface structures. This project expects to improve our knowledge of the causes of the tectonic stress field of Australia and its consequences for earthquake risk assessment, safe and sustainable usage of underground environments for groundwater exploration and production, CO2 sequestration, waste disposal, mine stability, exploration and production of hydrocarbon and geothermal resources.Read moreRead less
Impact of Native Title on Local Government in Australia. This project will consider in detail the Integrated Planning Act 1997 (Qld) (IPA) and how the implementation IPA Planning Schemes will impact upon native title rights to land and sea. The project will also look at the impact of IPA on development applications made by native titleholders themselves. It will provide for identification and analysis of the relevant legal arrangements affecting native title, and the creation for taxonomy of imp ....Impact of Native Title on Local Government in Australia. This project will consider in detail the Integrated Planning Act 1997 (Qld) (IPA) and how the implementation IPA Planning Schemes will impact upon native title rights to land and sea. The project will also look at the impact of IPA on development applications made by native titleholders themselves. It will provide for identification and analysis of the relevant legal arrangements affecting native title, and the creation for taxonomy of impacts arising out of the interaction of the two legal regimes. The project will indicate strategies to facilitate cooperation between local planning authorities and indigenous stakeholders within existing legal structures.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100090
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Coastal Engineering Research Field Station (CERFS). This project aims to establish a Coastal Engineering Research Field Station (CERFS) with instrument modules for measuring waves, tides, currents, seabed and beach profiles and sediment characteristics. There are critical knowledge gaps in the understanding of coastal processes, including the effects of climate variability and change, and a need to generate long-term data-sets for calibration of coastal models against Australian conditions. The ....Coastal Engineering Research Field Station (CERFS). This project aims to establish a Coastal Engineering Research Field Station (CERFS) with instrument modules for measuring waves, tides, currents, seabed and beach profiles and sediment characteristics. There are critical knowledge gaps in the understanding of coastal processes, including the effects of climate variability and change, and a need to generate long-term data-sets for calibration of coastal models against Australian conditions. The coastal process data obtained will lead to improved models, management strategies and design guidelines improving techniques to address coastal infrastructure design, beach management strategies and impact assessment to meet the challenges of future major coastal development. This will help decision-makers to reduce the risk to coastal communities, coastal ecosystems and maritime operations from extreme storms, climate change, infrastructure development and urbanisation.Read moreRead less