Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
An Australian storm wave damage and beach erosion early warning system. This project aims to develop a new coastal hazard early-warning system capability for Australia, to alert coastal communities, emergency managers and coastal engineers to impending storm wave damage and coastal erosion. Emergency preparedness informed by early warning is expected to significantly benefit vulnerable communities and infrastructure along Australia’s coasts.
Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by r ....Fish Jenga: metapopulation management for coastal river fish. This project aims to address the escalating threats to coastal freshwater fish from drought, fire, and other disturbances. The project expects to generate new knowledge on contemporary distributions of NSW coastal freshwater fishes, and will develop models of population dynamics to explore the consequences of alternative water management and disturbance scenarios. The expected outcome of the project is to revolutionise management by replacing the current practice of managing river basins separately, with a framework that accounts for among-basin linkages that are essential for the long-term persistence of fish populations. Significant benefits include more efficient use of water resources and improved conservation outcomes for native fish.Read moreRead less
The Molecular Determinants Of Immunological Tolerance
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
Autoimmune diseases, such as type I diabetes and multiple sclerosis, are debilitating disorders that impose a massive toll on wellbeing in Australia and worldwide. This fellowship will support research aimed at determining the genes and mechanisms that control autoimmunity. New technologies will be brought to bear to track immune cells throughout their development, maturity and malfunction in disease settings. We aim to uncover new therapeutic targets to prevent and reverse autoimmune disease.
Discovery Early Career Researcher Award - Grant ID: DE180101154
Funder
Australian Research Council
Funding Amount
$363,996.00
Summary
Regulating cumulative environmental effects: Designing global best practice. This project aims to analyse and evaluate laws regulating cumulative environmental effects in the United States of America, European Union, Canada and Australia. The project will use methods combining law, ethics, and natural and spatial science to develop a framework of globally relevant best practice tools for regulating cumulative effects. The outcomes will increase the capacity of regulators, industry, and the commu ....Regulating cumulative environmental effects: Designing global best practice. This project aims to analyse and evaluate laws regulating cumulative environmental effects in the United States of America, European Union, Canada and Australia. The project will use methods combining law, ethics, and natural and spatial science to develop a framework of globally relevant best practice tools for regulating cumulative effects. The outcomes will increase the capacity of regulators, industry, and the community to better manage common challenges in managing environmental effects and reducing environmental harms.Read moreRead less
Methylation Sensitive Genes And The Transition To Allergic Disease: A Twin Study
Funder
National Health and Medical Research Council
Funding Amount
$493,843.00
Summary
Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in ....Australia has amongst the highest reported prevalence allergic conditions (including asthma) in the world. Despite this, little is known about how these conditions arise. Mounting evidence implicates environmentally induced disruption of the genetic blueprint via a process known as epigenetics. We are combining the strengths of a unique collection of identical twins where one of a pair is sensitive to house dust mite, with cutting edge genomics, to characterise the pathways leading to allergy in children.Read moreRead less