Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to im ....Origins and distributions of intraplate earthquakes. This project aims to investigate the behaviour and origin of intraplate earthquakes in Australia by developing a multi-million-year record of earthquakes using geological, geochronological, geospatial, seismological, statistical and numerical modelling data. It will use maximum credible magnitudes, maximum shaking intensities of intraplate earthquakes and spatiotemporal relationships between large prehistoric and contemporary earthquakes to improve models of future seismic hazard in Australia and globally. This will lead to improved predictions of future earthquake impacts in urban and natural environments and development of new paleoseismic techniques.Read moreRead less
Snails to the rescue! Conservation of Australia’s island invertebrates. This project aims to deliver an exemplar industry network model for conservation on Australia’s islands which are hotspots both of biodiversity and of extinctions. Protecting species on islands is therefore key to securing Australia’s biodiversity. We will secure Norfolk Island's 60 species of land snails via in situ and ex situ conservation with six key industry partners. The project expects to unite conservation actions ac ....Snails to the rescue! Conservation of Australia’s island invertebrates. This project aims to deliver an exemplar industry network model for conservation on Australia’s islands which are hotspots both of biodiversity and of extinctions. Protecting species on islands is therefore key to securing Australia’s biodiversity. We will secure Norfolk Island's 60 species of land snails via in situ and ex situ conservation with six key industry partners. The project expects to unite conservation actions across research, governments, and industry. Expected outcomes of this project include Norfolk Island emerging as a leader in global conservation. This should provide significant benefits such as a model for conservation that is applicable to thousands of isolated, range-restricted invertebrate species across Australia.Read moreRead less
Forecasting drought impacts months ahead using satellite data. Skillful seasonal water and crop forecasts could do much to help cope with drought and water-related food crises. Recent advances in hydrological modelling and satellite remote sensing of surface soil moisture, landscape water storage and vegetation biomass have created a great opportunity to produce such forecasts over large areas. This project will exploit that opportunity by assimilating the satellite observations into a global wa ....Forecasting drought impacts months ahead using satellite data. Skillful seasonal water and crop forecasts could do much to help cope with drought and water-related food crises. Recent advances in hydrological modelling and satellite remote sensing of surface soil moisture, landscape water storage and vegetation biomass have created a great opportunity to produce such forecasts over large areas. This project will exploit that opportunity by assimilating the satellite observations into a global water and vegetation forecasting model. The resulting improvement in seasonal forecasts of stream flow, soil moisture and crop production will be quantified and compared to the limited forecasts that are currently available.Read moreRead less
Understanding the Origin and Development of Extreme and Mega Bushfires. Extreme and megafires result in significant damage to property and infrastructure and are associated with large suppression costs. These events form when separate fires Merge. Their increase occurrence in recent seasons highlights the importance of developing tools and technologies that better predict extreme events to aid fire response and inform strategies for greater resilience. This project combines fire field experiment ....Understanding the Origin and Development of Extreme and Mega Bushfires. Extreme and megafires result in significant damage to property and infrastructure and are associated with large suppression costs. These events form when separate fires Merge. Their increase occurrence in recent seasons highlights the importance of developing tools and technologies that better predict extreme events to aid fire response and inform strategies for greater resilience. This project combines fire field experiments with computer modelling to determine factors driving extreme fire development, and develop new knowledge and models. These enable better prediction of active fires, enhance the knowledge base of fire managers for critical decision making and to improve risk modelling and mitigation planning for fire-prone communities.Read moreRead less
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Has it always burned so hot? Fuel and fire in southeast Australian forests. Indigenous cultural burning has been raised as a way of mitigating against climate-driven catastrophic bushfires in southeast Australian forests. It is argued that returning an Indigenous style fire regime will keep landscape fuel loads low, thus reducing the frequency and intensity of bushfires and mitigating against large catastrophic bushfires. While based on enormous reservoirs of traditional fire knowledge in Indige ....Has it always burned so hot? Fuel and fire in southeast Australian forests. Indigenous cultural burning has been raised as a way of mitigating against climate-driven catastrophic bushfires in southeast Australian forests. It is argued that returning an Indigenous style fire regime will keep landscape fuel loads low, thus reducing the frequency and intensity of bushfires and mitigating against large catastrophic bushfires. While based on enormous reservoirs of traditional fire knowledge in Indigenous communities, this assertion needs empirical testing within these highly flammable forests. This project aims to empirically test how fuel loads, fuel type, fire frequency and fire intensity have changed over the past 500 years in southeast Australian forests, spanning the period of indigenous to British management.Read moreRead less
Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.
Special Research Initiatives - Grant ID: SR0354516
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Interdisciplinary Research Network on Property Rights in Natural Resource Management. Property rights are increasingly important in resource management, for titleholders and for the long-term viability of ecological resources. Property rights are historically and traditionally embedded in cultural practices and attitudes influencing the access, use and management of natural resources, ecosystem services and cultural assets. Understanding the history and future of property systems across social-e ....Interdisciplinary Research Network on Property Rights in Natural Resource Management. Property rights are increasingly important in resource management, for titleholders and for the long-term viability of ecological resources. Property rights are historically and traditionally embedded in cultural practices and attitudes influencing the access, use and management of natural resources, ecosystem services and cultural assets. Understanding the history and future of property systems across social-ecological landscapes is fragmented across disciplines, including natural sciences, social sciences and humanities. The interdisciplinary network on property rights in resource management will draw together researchers, building new synergies, novel research agendas and solutions for end users including property owners, resource managers, policy makers, planners and valuers.Read moreRead less
Sedimentary processes on sandy coasts in southern Australia. This project aims to reconstruct sedimentary processes and evolution of key coastal plains in southern Australia. These low-lying coasts, and the settlements and infrastructure on them, are vulnerable to inundation and shoreline erosion. Past behaviour of different types of coasts will be determined by combining innovative geospatial techniques to map morphology and past changes, geophysical imaging of stratigraphy and geochronology. T ....Sedimentary processes on sandy coasts in southern Australia. This project aims to reconstruct sedimentary processes and evolution of key coastal plains in southern Australia. These low-lying coasts, and the settlements and infrastructure on them, are vulnerable to inundation and shoreline erosion. Past behaviour of different types of coasts will be determined by combining innovative geospatial techniques to map morphology and past changes, geophysical imaging of stratigraphy and geochronology. The outcome will be models that explain responses to sediment availability, past storm history and sea-level changes. This will benefit sustainable coastal planning and management, providing geomorphological evidence to support erosion hazard assessments of these and adjacent coasts.Read moreRead less
A Multi-setting Intervention To Reduce Sedentary Behaviour, Promote Physical Activity And Improve Childrens Health
Funder
National Health and Medical Research Council
Funding Amount
$860,343.00
Summary
Sedentary behaviours and physical inactivity play a major role in the rising prevalence of obesity among children in Australia. This intervention study will take place in the school and family settings which play a critical role in shaping children's health behaviours. The objective is to determine whether a 2-year behavioural intervention reduces sedentary behaviour and promotes physical activity and results in improved health among 8-9 year old children.