How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharma ....How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharmaceutical intervention to delay the development of this debilitating disease. A 5 year delay would significantly reduce the number of people with AD, not only adding years of improved quality of life, but also saving hundreds of millions of Australian dollars in health costs.Read moreRead less
Studying the impact of pulsed magnetic fields on neural tissue. This project will determine the optimal parameters of pulsed magnetic fields for treating the ageing and/or damaged brain. The safety features, low cost and compact size of the medical device being investigated maximise compliance and make it relevant to populations in remote and rural areas.
Developing A Smart Farming Oriented Secure Data Infrastructure. Smart farming is the future of agriculture. However, recently the Federal Bureau of Investigation has issued a
warning that the lack of data privacy and cyber security mechanisms in the field runs a high risk of disaster. This
project aims to establish an innovative secure data infrastructure for smart farming including secure and automated smart farming supply-chain management. The deliverables of this project will include the cutt ....Developing A Smart Farming Oriented Secure Data Infrastructure. Smart farming is the future of agriculture. However, recently the Federal Bureau of Investigation has issued a
warning that the lack of data privacy and cyber security mechanisms in the field runs a high risk of disaster. This
project aims to establish an innovative secure data infrastructure for smart farming including secure and automated smart farming supply-chain management. The deliverables of this project will include the cutting-edge Blockchain based secure IoT data management and privacy-preserving smart contracts for smart farming supply-chain management. This data infrastructure will be the first of its kind which will lay a solid foundation for smart farming technology.Read moreRead less
Structure-activity relationships in the development of new bioactive isoflavonoids. This project aims to develop new chemical substances based on the structure of a group of naturally occuring compounds called isoflavones. Biological activity related to chronic inflammatory (eg arthritis) and heart disease will be examined in cells and animal models. This information will be used to design compounds with enhanced activity. The eventual aim is to develop potential therapeutic agents to treat chr ....Structure-activity relationships in the development of new bioactive isoflavonoids. This project aims to develop new chemical substances based on the structure of a group of naturally occuring compounds called isoflavones. Biological activity related to chronic inflammatory (eg arthritis) and heart disease will be examined in cells and animal models. This information will be used to design compounds with enhanced activity. The eventual aim is to develop potential therapeutic agents to treat chronic inflammatory and cardiovascular disease.Read moreRead less
Designing Distributed Intrusion Detection Systems for Critical Industrial Infrastructures. SCADA systems are computerized systems that control and monitor industrial and critical infrastructures, such as power grid, gas and water facilities and nuclear power plants. Many cyber-attacks on SCADA systems make such systems vulnerable. Also there is an increasing risk that SCADA vulnerabilities could be exploited by terrorist organizations. The security of SCADA systems of critical infrastructures ha ....Designing Distributed Intrusion Detection Systems for Critical Industrial Infrastructures. SCADA systems are computerized systems that control and monitor industrial and critical infrastructures, such as power grid, gas and water facilities and nuclear power plants. Many cyber-attacks on SCADA systems make such systems vulnerable. Also there is an increasing risk that SCADA vulnerabilities could be exploited by terrorist organizations. The security of SCADA systems of critical infrastructures has enormous and direct impact to our national security, economy and social life because of potential disasters that could happen from natural causes as well as malicious attacks. This project aims to investigate the relevant issues and provide efficient and reliable technological solutions to detect and prevent such problems.Read moreRead less
Smart technologies for people with vision impairment and blindness. Our technological solutions for early detection of disease provide the best opportunity for effective treatment, and provision of strategies capable of assisting individuals. It aims to empower primary care providers and will lead to more effective screening methods and improved efficiencies in redirecting resources towards those whose eye disease is treatable. It will further improve and enable access to specialist eye care fo ....Smart technologies for people with vision impairment and blindness. Our technological solutions for early detection of disease provide the best opportunity for effective treatment, and provision of strategies capable of assisting individuals. It aims to empower primary care providers and will lead to more effective screening methods and improved efficiencies in redirecting resources towards those whose eye disease is treatable. It will further improve and enable access to specialist eye care for those living in rural, regional and remote locations. The assistive technologies for the blind will greatly enhance the quality of life of the visually impaired, enhancing their quality of life and removing several risk factors. The net annual savings to the Government from these projects would be considerable.Read moreRead less
INTELLIGENT SURVEILLANCE SYSTEMS FOR THE TRANSPORT INDUSTRY. Addressing core issues in Research Priority 4, Safeguarding Australia, we will develop frontier technologies for intelligent surveillance of public spaces, particularly in the transportation sector. The key outcomes of this project will be the use of a variety of novel sensors, in combination with new algorithms for analysing and responding to critical patterns of sensor data. Our collaboration with two high-profile industrial partners ....INTELLIGENT SURVEILLANCE SYSTEMS FOR THE TRANSPORT INDUSTRY. Addressing core issues in Research Priority 4, Safeguarding Australia, we will develop frontier technologies for intelligent surveillance of public spaces, particularly in the transportation sector. The key outcomes of this project will be the use of a variety of novel sensors, in combination with new algorithms for analysing and responding to critical patterns of sensor data. Our collaboration with two high-profile industrial partners with complementary capabilities, (DTI (specialising in public transport), and iOmniscient (specialising in surveillance technologies)), will ensure a high probability of success in the development of these technologies, and accelerate their introduction into the Australian and global markets.Read moreRead less
Intelligent Security in Urban Spaces. Successful completion of this work will contribute greatly to Safeguarding Australia, Priority Area 4, and lead to further commercial exploitation on the national and international stages. In particular, we are responding to increasing demand from our partners for sophisticated surveillance systems for infrastructure and public transport. The adoption of these technologies by DTI, with international contracts for video surveillance, positions Australia to ga ....Intelligent Security in Urban Spaces. Successful completion of this work will contribute greatly to Safeguarding Australia, Priority Area 4, and lead to further commercial exploitation on the national and international stages. In particular, we are responding to increasing demand from our partners for sophisticated surveillance systems for infrastructure and public transport. The adoption of these technologies by DTI, with international contracts for video surveillance, positions Australia to gain the leading edge in this niche industry. Additionally we deliver solutions to our end user partners, PTA and WA Police, to facilitate enhanced community security. We will also build research capacity for surveillance technologies through advanced training of research staff.Read moreRead less
Developing smart embedded host-based intrusion detection systems. Computer intrusion is a major concern in many places. It is estimated that cybercrime cost firms US$1 trillion globally in 2008. Many serious cyber attacks, including cyber espionage, do not generate significant network traffic and can easily penetrate network-based intrusion detection systems (NIDS). Such attacks often attempt to compromise individual hosts and hence they are best detected at the host level. We aim to design i ....Developing smart embedded host-based intrusion detection systems. Computer intrusion is a major concern in many places. It is estimated that cybercrime cost firms US$1 trillion globally in 2008. Many serious cyber attacks, including cyber espionage, do not generate significant network traffic and can easily penetrate network-based intrusion detection systems (NIDS). Such attacks often attempt to compromise individual hosts and hence they are best detected at the host level. We aim to design innovative host-based IDS, as a complement to the NIDS, to address this issue. The outcomes of this project will strengthen the national capability to resist attacks by criminals and terrorists on Australian networked critical infrastructures and also enhance the global competitiveness of Australia’s information technology industry.Read moreRead less
Detecting Supervisory Control and Data Access (SCADA) malicious programs to protect Australian critical infrastructure. The security of SCADA systems has enormous impact to our national security and economy because they control and monitor critical infrastructure, like power, gas and water facilities and nuclear power plants, etc. This project aims to investigate the security issues and provide innovative technological solutions to detect and prevent such problems.