Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suic ....Preventing railway suicide: An open-systems perspective. Preventing railway suicide: An open-systems perspective. This project aims to develop an automated suicide risk detection system to reduce the incidence and impact of railway suicide, which has a devastating effect on victims’ families, station staff, train drivers, emergency workers, and bystanders. This project will use open-systems theory to develop two complementary information systems for more effective detection and reporting of suicide risk; use these systems to investigate how different situational factors interact with different combinations of service interventions to influence suicide risk; and share the findings to reduce railway suicide in Australia and overseas.Read moreRead less
Efficacy profiling innovation in novel pain therapeutics discovery. The purpose of this project is to bring innovation into the methods used for selecting novel compounds with high potential for progression into development as highly effective pain-killers for improving the relief of chronic pain. This will result in new pain-killers that are highly effective without producing unpleasant side-effects.
A novel cooperative global information system for healthcare. This project will develop a global model for healthcare based on the groundbreaking Protocol Hypothesis Testing (PHT) system, allowing expert groups of clinicians to create and share knowledge across organizations. The PHT is a unique functioning knowledge management system that allows clinicians to record patient and treatment data as it is generated in clinical practice and applies scientific methods to generate clinical knowledge, ....A novel cooperative global information system for healthcare. This project will develop a global model for healthcare based on the groundbreaking Protocol Hypothesis Testing (PHT) system, allowing expert groups of clinicians to create and share knowledge across organizations. The PHT is a unique functioning knowledge management system that allows clinicians to record patient and treatment data as it is generated in clinical practice and applies scientific methods to generate clinical knowledge, all in real-time. The project will develop and test a framework for the PHT system to be used cooperatively by expert groups across virtual organizations, refining the PHT system in the process.Read moreRead less
Discovery and characterisation of novel spider-venom peptides targeting the human sodium ion channel Nav1.7. Drugs that selectively block the human sodium ion channel Nav1.7 are likely to be powerful analgesics for treating a wide variety of pain conditions. However, it has proved difficult to obtain selective blockers of this channel. The aim of this project is to determine whether spider-venoms might provide a source of highly selective Nav1.7 blockers.
Information systems theory for location-based educational services in informal learning environments. Creating technology enhanced learning experiences will be critical to the way we educate and engage with future generations. This project will seek to develop a stronger theoretical basis for understanding how location-based technologies can enhance learning outcomes of school students visiting three of Australia's leading cultural institutions.
Examining multi-level Information Technology (IT) project alignment in government services: the case of contracted employment services. Improved Information Technology (IT) alignment is essential for the delivery of government services within a complex public-private, inter-organisational environment. This project will investigate the extent to which well-aligned IT support systems contribute positively to the efficient and effective delivery of contracted employment services.
Integrated Intelligent Decision Support for Field Design and Management of Census Operations in Australia. This project contributes to a more reliable and accurate measurement of the number and key characteristics of Australian people by supporting a more efficient and effective field design and management of the Census operations. As the Census provides a snapshot of Australia and is crucial to communities, private institutions and all levels of government in the planning of services and facili ....Integrated Intelligent Decision Support for Field Design and Management of Census Operations in Australia. This project contributes to a more reliable and accurate measurement of the number and key characteristics of Australian people by supporting a more efficient and effective field design and management of the Census operations. As the Census provides a snapshot of Australia and is crucial to communities, private institutions and all levels of government in the planning of services and facilities, this project not only addresses the research priority of smart information use, but also contributes to strengthening Australia's social and economic fabric. This project will also train highly qualified IT specialists critical to Australia's scientific and industrial development, thus increasing our competitiveness in information technology R&D.Read moreRead less
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resou ....Transforming Microgrid to Virtual Power Plant –ICT Frameworks,Tools,Control. The project aims to enhance large scale renewable penetrations to national power grid by advancing control, optimization, and ancillary services of Virtual Power Plants (VPPs), considering different disruptive events including recent South Australian blackout. This project expects to create new control, frame communication architecture, develop plug and play type IoT enabled grid interfacing inverter, and optimize resource management for distributed VPPs. The anticipated benefits from this institutional level collaborations are that VPPs help in enhancing national power grid operations during normal and disruptive conditions when more renewables are connected and also secure benefits of consumers, prosumers, and grid operators.Read moreRead less