Mechanism of glutamate transport from experimental and simulation studies. Glutamate transporters play key roles in shaping the electrical signaling in the brain. Under conditions of stress or after a stroke, glutamate transporter function is impaired, which can lead to excessive levels of glutamate, cell death and impaired brain function. The project will help to decipher the operation of glutamate transporters at a molecular level and provide greater understanding of how glutamate levels are c ....Mechanism of glutamate transport from experimental and simulation studies. Glutamate transporters play key roles in shaping the electrical signaling in the brain. Under conditions of stress or after a stroke, glutamate transporter function is impaired, which can lead to excessive levels of glutamate, cell death and impaired brain function. The project will help to decipher the operation of glutamate transporters at a molecular level and provide greater understanding of how glutamate levels are controlled, which is vital for developing better treatments for neurological disorders such as stroke. The project will also provide research training in experimental/computational molecular biology, which is a rapidly growing field underpinning the biotechnological and pharmaceutical industries. Read moreRead less
Special Research Initiatives - Grant ID: SR0354794
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Astronomy. Australian e-Astronomy will provide a pre-eminent example of an integrated e-Science program. The Australian e-Astronomy Research Network will build on and extend the LIEF-funded national program to participate in the International Virtual Observatory. The network includes key members of most Australian astronomy research groups, a strong group representing grid research and advanced computing partnerships and an extensive group of international experts. The network dev ....Australian e-Astronomy. Australian e-Astronomy will provide a pre-eminent example of an integrated e-Science program. The Australian e-Astronomy Research Network will build on and extend the LIEF-funded national program to participate in the International Virtual Observatory. The network includes key members of most Australian astronomy research groups, a strong group representing grid research and advanced computing partnerships and an extensive group of international experts. The network developed by Australian e-Astronomy will service the entire Australian astronomical research community (eg theory codes, databases, software telescopes) and provide new programs for postgraduate research training.Read moreRead less
Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operati ....Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operation and seeking cures for diseases caused by their malfunction. This project aims to develop accurate ion-protein-water interactions for permeation models based on stochastic and molecular dynamics simulations using both classical and quantum mechanical methods.Read moreRead less
Quantum mechanical and dynamical investigation of ion channels. Many genetic diseases result from mutations in the genes that transcribe the channel proteins. Ion channels are also primary targets for development of therapeutic drugs for many ailments. Development of proper simulation tools is essential for a molecular-level understanding of their operation, which will be very helpful in finding treatments for genetic diseases as well as new drugs that target ion channels. Another aim of the p ....Quantum mechanical and dynamical investigation of ion channels. Many genetic diseases result from mutations in the genes that transcribe the channel proteins. Ion channels are also primary targets for development of therapeutic drugs for many ailments. Development of proper simulation tools is essential for a molecular-level understanding of their operation, which will be very helpful in finding treatments for genetic diseases as well as new drugs that target ion channels. Another aim of the project is to provide research training in computational biology. Research in this area is rapidly growing elsewhere but it has been rather neglected in Australia, and there is a shortage of researchers with such skills at present.Read moreRead less
Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales ....Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales with molecular dynamics at small distances and shorter times. Applications to both membrane proteins (blocking of ion channels by toxins and drugs) and globular proteins (ligand binding to receptors and protein association) will be considered.Read moreRead less
Silk Fibroin Optofluidic Chips. Unlike any other material, even any other biologically occurring material, silk is unique in being very transparent, able to be shaped on a very small scale and can keep natural chemicals like proteins and enzymes active. This project will use silk to make optical devices and sensors. Optics made from silk will have all these properties, which means that they can be used as sensors and devices in biochemistry applications that have never been possible before. Thes ....Silk Fibroin Optofluidic Chips. Unlike any other material, even any other biologically occurring material, silk is unique in being very transparent, able to be shaped on a very small scale and can keep natural chemicals like proteins and enzymes active. This project will use silk to make optical devices and sensors. Optics made from silk will have all these properties, which means that they can be used as sensors and devices in biochemistry applications that have never been possible before. These cost-effective devices will have the potential to enhance healthcare, emergency medicine and assist early medical diagnosis.Read moreRead less
Photonic Crystal Signal Processing and Antenna Technologies. The information society in which we live requires increasingly high bandwidth, low cost communications. This project addresses two critically important technologies needed to meet these demands: signal processing devices and antennas. These devices will be designed using three-dimensional photonic crystals, which provide excellent possibilities for low-cost, highly integrated photonic circuits. Working prototypes will be built at micro ....Photonic Crystal Signal Processing and Antenna Technologies. The information society in which we live requires increasingly high bandwidth, low cost communications. This project addresses two critically important technologies needed to meet these demands: signal processing devices and antennas. These devices will be designed using three-dimensional photonic crystals, which provide excellent possibilities for low-cost, highly integrated photonic circuits. Working prototypes will be built at microwave frequencies, but due to the scalability of electromagnetic theory these results are also valid in the optical domain. The outcomes of this project will be accurate theoretical models and empirical tests for new technologies that satisfy the future needs of the information society.Read moreRead less
Robust and Distributed Control of Quantum Systems. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust and distributed feedback controllers for quantum systems. The project will also add to Australia's strength in quantum ....Robust and Distributed Control of Quantum Systems. Australia has considerable strengths in quantum technology research. As these technologies advance, the issue of control and in particular feedback control becomes a critical one. This research project will strengthen Australia's position in quantum technology by developing new methodologies for designing high performance robust and distributed feedback controllers for quantum systems. The project will also add to Australia's strength in quantum technology by contributing to the research training of young researchers with expertise both in control systems engineering and quantum technology. This project will help Australia reap the maximum possible benefit from the new industries to emerge from the field of quantum technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347140
Funder
Australian Research Council
Funding Amount
$208,000.00
Summary
Picosecond optical probing and characterization of infrared and visible devices. The facility consists of a laser to generate short infrared pulses, and an oscilloscope and detectors to measure such pulses. It will be used to characterize and investigate a new generation of novel optical fibre devices and microstructures, which are to form the basis of the next generation of telecommunications systems, and also novel and unique laser types. The research and development of all of these devices ar ....Picosecond optical probing and characterization of infrared and visible devices. The facility consists of a laser to generate short infrared pulses, and an oscilloscope and detectors to measure such pulses. It will be used to characterize and investigate a new generation of novel optical fibre devices and microstructures, which are to form the basis of the next generation of telecommunications systems, and also novel and unique laser types. The research and development of all of these devices are receiving external funding (or are in negotiations therefore). The facility allows for high-speed and high-accuracy data acquisition, which makes it unique in Australia.Read moreRead less
Novel multi-channel and nonlinear Bragg grating devices. High capacity and reliable telecommunications links are essential for many aspects of modern life and work. Optical fibres offer essentially unlimited capacity, but their optimal use requires the transmission of multiple wavelength channels simultaneously. This, in turn, requires the development of special-purpose fibre devices for multiplexing and de-multiplexing these channels, as well as for other optical filtering and switching tasks. ....Novel multi-channel and nonlinear Bragg grating devices. High capacity and reliable telecommunications links are essential for many aspects of modern life and work. Optical fibres offer essentially unlimited capacity, but their optimal use requires the transmission of multiple wavelength channels simultaneously. This, in turn, requires the development of special-purpose fibre devices for multiplexing and de-multiplexing these channels, as well as for other optical filtering and switching tasks. Fibre Bragg gratings are central to many of these devices, and the aim of this project is to develop novel designs for linear and nonlinear Bragg grating devices which may significantly widen the current range of their applications.Read moreRead less