Motion-adaptive PET technology for brain imaging of freely moving mice. This project aims to develop new brain imaging technology that adapts to and corrects for the motion of a responsive, freely moving mouse. Current technology requires the subject to be unconscious, precluding the use of imaging to study signalling pathways activated by external stimuli during cognitive and behavioural tasks. By harnessing new radiation detector, motion tracking and computational technologies, the project exp ....Motion-adaptive PET technology for brain imaging of freely moving mice. This project aims to develop new brain imaging technology that adapts to and corrects for the motion of a responsive, freely moving mouse. Current technology requires the subject to be unconscious, precluding the use of imaging to study signalling pathways activated by external stimuli during cognitive and behavioural tasks. By harnessing new radiation detector, motion tracking and computational technologies, the project expects to bridge this technology gap and provide significant technical and conceptual advances in the field. This will provide important benefits, such as equipping neuroscientists with new tools to answer fundamental questions about how the mammalian brain regulates behavioural adaptation to a changing environment.Read moreRead less
Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and d ....Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and data storage systems. Despite its success, the technique’s spatial resolution and quantitative measurements are limited. This project could lead to breakthrough technologies such as atomic force spectroscopy to study elastic modulus of nanostructures, and establish Australia's prominence in this emerging field.Read moreRead less
Subsurface Atomic Force Microscopy using Dual Probes. The proposal aims to develop a new microscopy method for imaging nano-scale structures buried below the surface of a sample; for example, metal conductors in a computer processor chip. The expected outcome is a new method for creating subsurface images with an application focus on semiconductor device inspection and quality control. The proposed microscope is expected to create new economic opportunities including new commercial products, int ....Subsurface Atomic Force Microscopy using Dual Probes. The proposal aims to develop a new microscopy method for imaging nano-scale structures buried below the surface of a sample; for example, metal conductors in a computer processor chip. The expected outcome is a new method for creating subsurface images with an application focus on semiconductor device inspection and quality control. The proposed microscope is expected to create new economic opportunities including new commercial products, intellectual property, and the potential for a start-up venture. The benefits to Australia should include the creation of new job opportunities and the development of local expertise in a high-value market sector.Read moreRead less
A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using ....A miniaturised laser manipulator for ultra-precise and pain-free dentistry. This project aims to develop a miniaturized high-precision laser robotic device that can fit comfortably in the mouth to perform pain-free, vibration-free dental operations by utilising silicon-carbide on silicon technology to create a millimetre-sized two-axis controllable, highly-reflective mirror robust to high-power ultra-short laser pulses. This project expects to generate new knowledge in micro-mirror control using optically excited piezo-resistive sensors, and cold femtosecond laser ablation of hard dental tissue. Expected outcomes include a working prototype for laser removal of tooth materials at speeds exceeding dental drills, providing benefits in miniaturized laser devices and ultimately removing pain from dental procedures. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100029
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
High Resolution PET-CT for Small Animal Molecular and Anatomical Imaging. This project will integrate a next generation small animal PET-CT instrument into the Sydney Imaging multi-modality imaging ecosystem. PET-CT enables the investigation of molecular function and anatomical structure in complex living organisms. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets in the bo ....High Resolution PET-CT for Small Animal Molecular and Anatomical Imaging. This project will integrate a next generation small animal PET-CT instrument into the Sydney Imaging multi-modality imaging ecosystem. PET-CT enables the investigation of molecular function and anatomical structure in complex living organisms. This platform will enable research as diverse as the development and in-vivo characterisation of new chemical probes and nanoparticles that bind to specific protein targets in the body, investigating mechanisms of brain plasticity in predictive learning, understanding the molecular pathways involved in neurodegeneration and cancer, developing novel methods for multi-modal image analysis, and developing and validating new radiation detectors for the next generation of imaging technology.Read moreRead less
A New Nano Tip Fabrication Technique for Atomic Force Microscopy. This project aims to develop a new fabrication technique for high-aspect-ratio (long and sharp) tips for atomic force microscopy. The technique is expected to overcome the current fabrication limitation, that is fabricating one tip at a time which is unsuitable for batch fabrication. The proposed technique can be scaled up to mass produce nano tips. The technique is expected to create new commercial products and intellectual prope ....A New Nano Tip Fabrication Technique for Atomic Force Microscopy. This project aims to develop a new fabrication technique for high-aspect-ratio (long and sharp) tips for atomic force microscopy. The technique is expected to overcome the current fabrication limitation, that is fabricating one tip at a time which is unsuitable for batch fabrication. The proposed technique can be scaled up to mass produce nano tips. The technique is expected to create new commercial products and intellectual property. This innovation will lead to the emergence of breakthrough technologies in nanofabrication and nanomaterials synthesis. The benefits to Australia include new job opportunities and the development of local expertise in the field.Read moreRead less
Innovative Electrohydrodynamic Atomisation for Improved Nasal Drug Delivery. Inhalation offers high and rapid drug absorption into the bloodstream. This project aims to establish key technologies for a revolutionary system in inhaled nanomedicine delivery. The study will investigate the underlying physics of nanoparticles to create a world-first electrostatic nebuliser, enabling the more effective drug delivery. This technique is expected to overcome the current limitations by providing better c ....Innovative Electrohydrodynamic Atomisation for Improved Nasal Drug Delivery. Inhalation offers high and rapid drug absorption into the bloodstream. This project aims to establish key technologies for a revolutionary system in inhaled nanomedicine delivery. The study will investigate the underlying physics of nanoparticles to create a world-first electrostatic nebuliser, enabling the more effective drug delivery. This technique is expected to overcome the current limitations by providing better control over the size and charge of delivered drugs. The outcomes of this project will benefit pharmaceutical companies in developing products with more efficient nasal delivery of advanced drugs, vaccines, and nanocariers, make it easier for doctors to prescribe, and benefit patients with more accurate dosages.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100178
Funder
Australian Research Council
Funding Amount
$453,913.00
Summary
Fast, lightweight and live nanopore sequencing analysis. This project aims to address limitations in nanopore sequencing (latest emerging technology in genomics) by applying advanced computational methods. This project expects to create new knowledge in bioinformatics and computer science through innovative approaches that leverage the live data streaming capability of nanopore devices to deliver results rapidly, or in real-time. Expected outcomes include improved, highly efficient analysis meth ....Fast, lightweight and live nanopore sequencing analysis. This project aims to address limitations in nanopore sequencing (latest emerging technology in genomics) by applying advanced computational methods. This project expects to create new knowledge in bioinformatics and computer science through innovative approaches that leverage the live data streaming capability of nanopore devices to deliver results rapidly, or in real-time. Expected outcomes include improved, highly efficient analysis methods and designs for future creation of custom computer hardware for nanopore analysis. This will facilitate widespread adoption of nanopore technology in bioscience research and applied domains (health, agriculture, ecology, biosecurity and forensics), including for portable in-the-field applications. Read moreRead less
Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology ....Noise-free Cryogenic Wavefront Sensing. This project aims to optimise the prototype adaptive optics technology for the Giant Magellan Telescope (GMT) by leveraging past investment in adaptive optics instrumentation and shortwave infrared detector systems. This project expects to generate significant improvements in GMT performance, with ten times greater image resolution than the Hubble Space Telescope and current estimates of >90% sky coverage, compared with ~50% coverage for current technology. Expected outcomes of this project include the development of a highly trained workforce and continued international collaboration in the field of high-technology sensor systems. This contribution to the GMT will provide significant benefits—it will change the way we view the Universe.Read moreRead less
Parallel Lines: Ultra-dense optical systems for extreme data-rates. The project aims to explore methods to significantly expand global internet data rates, by using emerging ultra-dense optical technologies. The project plans to discover how novel existing and emerging tiny photonic chip devices may enable the use of new, unused optical spectral bands, and then enable 1000s of channels to be supported by exploiting newly available parallelism in both wavelength and space. Success in the project ....Parallel Lines: Ultra-dense optical systems for extreme data-rates. The project aims to explore methods to significantly expand global internet data rates, by using emerging ultra-dense optical technologies. The project plans to discover how novel existing and emerging tiny photonic chip devices may enable the use of new, unused optical spectral bands, and then enable 1000s of channels to be supported by exploiting newly available parallelism in both wavelength and space. Success in the project aims may enable speeds of up to 100 times greater than achievable today, in a variety of fibre optic systems. Connectivity is key to our society, so benefits may arise in both future-proofing key Australian data infrastructure, and in providing a roadmap to support exponential capacity growth over the coming decades.Read moreRead less