Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882701
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Establishment of a confocal/multiphoton microscope for imaging of living systems. This facility will allow us to study the dynamic changes in living systems, from the smallest unicellular organisms in the ocean through to the sophisticated neural networks of the living brain. Not only will this imaging facility allow us to understand how living systems work, we will also be able to explore the dynamic changes that underlie human disease and injury.
Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operati ....Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operation and seeking cures for diseases caused by their malfunction. This project aims to develop accurate ion-protein-water interactions for permeation models based on stochastic and molecular dynamics simulations using both classical and quantum mechanical methods.Read moreRead less
Special Research Initiatives - Grant ID: SR0354793
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a mul ....A Neural Network: Understanding Brain Function. This proposal focuses on the mechanisms that regulate brain function, particularly those underpinning the changes in circuitry (plasticity) caused by altered inputs. As such, its core goal is to create an interface between researchers in the neurosciences, computational modelling, robotics and cognitive sciences in order to facilitate optimum collaborative interactions, identify key research questions and promote training opportunities across a multidisciplinary spectrum. This will drive an integrated and accelerated program of discovery and technological development, enhancing Australia's leadership in this crucial field and helping to highlight new biotechnology opportunities and capture social and economic benefits for the nation. Read moreRead less
To flee or not to flee: surviving on incomplete information. Even lowly animals, like the Australian fiddler crabs we will be investigating, are surprisingly competent in making the right decisions in complex situations. They actively acquire information and make good use of it to assure their immediate safety and their long term gains. Animals are exquisitely honed by evolution and we would benefit greatly by understanding what makes them so competent: on a theoretical level, we may learn about ....To flee or not to flee: surviving on incomplete information. Even lowly animals, like the Australian fiddler crabs we will be investigating, are surprisingly competent in making the right decisions in complex situations. They actively acquire information and make good use of it to assure their immediate safety and their long term gains. Animals are exquisitely honed by evolution and we would benefit greatly by understanding what makes them so competent: on a theoretical level, we may learn about efficient rules of good decision making and on a practical level, we may be able to design more flexible, robust and clever machines. Besides being useful in this wider context, the results of our research will thus also contribute to a new and 'sophisticated' appreciation of the cognitive design of animal.Read moreRead less
Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales ....Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales with molecular dynamics at small distances and shorter times. Applications to both membrane proteins (blocking of ion channels by toxins and drugs) and globular proteins (ligand binding to receptors and protein association) will be considered.Read moreRead less
Theoretical Studies on the KcsA Potassium Channel and the L-type Calcium Channel. All electrical activities in the brain are regulated by opening and closing of ion channels. Thus, understanding their mechanisms is a fundamental problem in biology. The project is aimed at developing a theoretical model of two important types of ion channels. Using a supercomputer, we will first deduce the shape of the microstructure formed by a protein wall. Then, using a computer simulation technique, we will c ....Theoretical Studies on the KcsA Potassium Channel and the L-type Calcium Channel. All electrical activities in the brain are regulated by opening and closing of ion channels. Thus, understanding their mechanisms is a fundamental problem in biology. The project is aimed at developing a theoretical model of two important types of ion channels. Using a supercomputer, we will first deduce the shape of the microstructure formed by a protein wall. Then, using a computer simulation technique, we will construct a set of physical models of biological ion channels, which will correctly replicate experimental observations. Such a theory will link the structure and function of an ion channel through the fundamental principles of physics.Read moreRead less
Moving between day and night: Navigational strategies and foraging costs of temporal niche partitioning. This study involves fundamental research to identify the navigational strategies and the foraging cost in animals that occupy different temporal niches. It will make use of the unique research opportunities in Australia, by working with endemic fauna that allows scientists to address questions that would otherwise be hard to answer. The project will introduce the novel technique of differenti ....Moving between day and night: Navigational strategies and foraging costs of temporal niche partitioning. This study involves fundamental research to identify the navigational strategies and the foraging cost in animals that occupy different temporal niches. It will make use of the unique research opportunities in Australia, by working with endemic fauna that allows scientists to address questions that would otherwise be hard to answer. The project will introduce the novel technique of differential GPS to track the paths of ants which has the potential to revolutionise the field of insect navigation. Salience-dependent navigational strategies analysed in this study will be of great interest in the field of engineering and robotics.Read moreRead less
Moving to be seen: a comprehensive analysis of movement-based signal design. Papers on visual motion processing and animal signal design regularly feature in major journals, and the programs of international conferences. We can thus be confident that theoretical advances will attract international attention. We will develop further state-of-the-art methods in motion analysis, with our overall approach likely to serve as a framework for future research programs, although our techniques will have ....Moving to be seen: a comprehensive analysis of movement-based signal design. Papers on visual motion processing and animal signal design regularly feature in major journals, and the programs of international conferences. We can thus be confident that theoretical advances will attract international attention. We will develop further state-of-the-art methods in motion analysis, with our overall approach likely to serve as a framework for future research programs, although our techniques will have applications outside of biology. In addition, we will learn much about the social behaviour of a group of native reptiles about which relatively little is known. Research on the social behaviour of animals is readily comprehended by non-specialists and plays an important role in attracting young people to careers in science.Read moreRead less
Special Research Initiatives - Grant ID: SR0354726
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
NETVISION: AUSTRALIA'S NATIONAL VISION RESEARCH NETWORK. Vision is the most important human sense. Visual malfunctions pose major health challenges. Vision provides a window into the brain, for studying perception, cognition and consciousness. It is integral to human cultural and social development. It provides opportunities for technological advances in diagnostics, artificial vision, robotics, and surveillance. Vision is therefore crucial to three of the National Priority Areas. The National V ....NETVISION: AUSTRALIA'S NATIONAL VISION RESEARCH NETWORK. Vision is the most important human sense. Visual malfunctions pose major health challenges. Vision provides a window into the brain, for studying perception, cognition and consciousness. It is integral to human cultural and social development. It provides opportunities for technological advances in diagnostics, artificial vision, robotics, and surveillance. Vision is therefore crucial to three of the National Priority Areas. The National Vision Network will create a coherent, interactive and innovative research base in the vision sciences, linked to end-users in areas ranging from the art, entertainment and fashion industries, through health and education, to border protection and counter-terrorism.Read moreRead less
Suction pipette measurements of mammalian rod photoreceptor recovery following intense bleaching exposures. The aim of this project is to discover the events and processes that prevent retinal photoreceptors from recovering instantaneously following the cessation of exposure to extremely bright illumination. Recordings will be made from single rod photoreceptors cells isolated from the mammalian retina. The work will uncover the relative roles of the 'photoproducts' created when rhodopsin abso ....Suction pipette measurements of mammalian rod photoreceptor recovery following intense bleaching exposures. The aim of this project is to discover the events and processes that prevent retinal photoreceptors from recovering instantaneously following the cessation of exposure to extremely bright illumination. Recordings will be made from single rod photoreceptors cells isolated from the mammalian retina. The work will uncover the relative roles of the 'photoproducts' created when rhodopsin absorbs light: e.g. intermediates such as metarhodopsin and opsin. The molecular knowledge obtained will help us to understand why it is that the visual system recovers so slowly after the eye has experienced very intense light.Read moreRead less