Democratisation of Deep Learning: Neural Architecture Search at Low Cost. The need to manually design Deep Learning-based Neural Networks (DNNs) limits their usage to AI experts and hinders the exploitation of their true potential more broadly, e.g., in farming, humanities. We aim to replace this tedious process through novel AI methods capable of generating DNNs that can perform significantly better and at a lower computational cost than manually designed DNNs. We further expand this idea to so ....Democratisation of Deep Learning: Neural Architecture Search at Low Cost. The need to manually design Deep Learning-based Neural Networks (DNNs) limits their usage to AI experts and hinders the exploitation of their true potential more broadly, e.g., in farming, humanities. We aim to replace this tedious process through novel AI methods capable of generating DNNs that can perform significantly better and at a lower computational cost than manually designed DNNs. We further expand this idea to solve complex real-world problems with both labelled and unlabelled data found in various applications including energy and climate change. The expected outcomes include the novel AI methods, highly trained AI researchers and a number of critical applications that will bring significant benefits to Australia and the world.Read moreRead less
Genetic control of floral architecture. Different flowers have different designs, and so the design must ultimately be controlled by genes. We have identified a gene that keeps sepals separate, and promotes the initiation of petals. We think it does this by a novel growth suppression mechanism, and will now deduce its molecular and cellular basis. This will help maintain Australia's strength in fundamental plant biology. Also, by understanding how sepals and petals arise in a model laboratory sp ....Genetic control of floral architecture. Different flowers have different designs, and so the design must ultimately be controlled by genes. We have identified a gene that keeps sepals separate, and promotes the initiation of petals. We think it does this by a novel growth suppression mechanism, and will now deduce its molecular and cellular basis. This will help maintain Australia's strength in fundamental plant biology. Also, by understanding how sepals and petals arise in a model laboratory species, we can generalise for many species, including economic plants. Thus it may be possible to make designer crops through targeted genetic changes to their floral structure.Read moreRead less
Control of plant organ development by the PETAL LOSS gene of Arabidopsis. We have discovered a new gene in the model laboratory plant Arabidopsis thaliana that is involved in sepal and petal development. It encodes a transcription factor that apparently acts by repressing growth in the inter-sepal zone of flowers where petals arise. We now aim to determine how this growth suppression occurs, and whether it extends to leaves where the gene is also expressed. Control of the initiation and sculptur ....Control of plant organ development by the PETAL LOSS gene of Arabidopsis. We have discovered a new gene in the model laboratory plant Arabidopsis thaliana that is involved in sepal and petal development. It encodes a transcription factor that apparently acts by repressing growth in the inter-sepal zone of flowers where petals arise. We now aim to determine how this growth suppression occurs, and whether it extends to leaves where the gene is also expressed. Control of the initiation and sculpturing of plant organs by site-specific inhibition of growth is a newly discovered mechanism that may be useful in manipulating plant architecture.Read moreRead less
Understanding how auxin and dorsoventral patterning are coordinated in plants. This study will help reveal for the first time how the outgrowth of leaves, flowers and floral organs is coordinated by tissue patterning genes and the plant growth hormone auxin. All plants grow in this way, and our findings, made using a model laboratory plant, will be applicable to crop species as well. Thus we will both expand our core knowledge of how multicellular organisms are constructed, and also generate pos ....Understanding how auxin and dorsoventral patterning are coordinated in plants. This study will help reveal for the first time how the outgrowth of leaves, flowers and floral organs is coordinated by tissue patterning genes and the plant growth hormone auxin. All plants grow in this way, and our findings, made using a model laboratory plant, will be applicable to crop species as well. Thus we will both expand our core knowledge of how multicellular organisms are constructed, and also generate possibilities for modifying the patterns of leaf and flower development in agricultural and horticultural species. Crops with larger leaves, or flowers of different structure, may result.Read moreRead less
Adaptive Evolution of BRCA1 in Ancestral Mammals. This project investigates adaptive evolution of BRCA1 in the early radiation of mammals. We will test the hypothesis that the evolution of mammary glands and X chromosome inactivation has resulted in modification of the BRCA1 protein sequence as it aquired new roles in these processes. We will also investigate the importance of these changes inducing compensatory changes in other parts of the protein.
A novel and efficient approach for optimisation involving iterative solvers. Computationally expensive simulations involving iterative solvers are increasingly being used in industry to assess performance of products and processes. Repeated use of such simulations is necessary to identify optimum solutions. Even with today's computing power, many such tasks remain computationally prohibitive. This project presents a novel approach to solve optimisation problems involving iterative solvers with l ....A novel and efficient approach for optimisation involving iterative solvers. Computationally expensive simulations involving iterative solvers are increasingly being used in industry to assess performance of products and processes. Repeated use of such simulations is necessary to identify optimum solutions. Even with today's computing power, many such tasks remain computationally prohibitive. This project presents a novel approach to solve optimisation problems involving iterative solvers with limited computing budget. A wide range of industries involved in product and process design would gain a significant competitive advantage from this unique technical innovation. In addition, this technology will be invaluable to uncover and understand complex natural phenomena.Read moreRead less
Adaptive modelling of human responses in complex interaction. This project aims to combine strengths of human cognition and evolutionary computing to efficiently solve problems which neither can do alone. The project will develop techniques combining advanced non-intrusive sensor measures of behaviour and emotional reaction in interaction tasks to enable high level computer support for human goal seeking, in complex data and design environments. This project will allow non-expert users to use to ....Adaptive modelling of human responses in complex interaction. This project aims to combine strengths of human cognition and evolutionary computing to efficiently solve problems which neither can do alone. The project will develop techniques combining advanced non-intrusive sensor measures of behaviour and emotional reaction in interaction tasks to enable high level computer support for human goal seeking, in complex data and design environments. This project will allow non-expert users to use tools normally requiring extensive training in settings where the user can 'see' when they get something they like but do not know how to instruct a computer system to show or do it. Applications of the project will include visualisation for bespoke manufacturing or for high dimensional data, generating abstract art, or improving teleconferencing systems.Read moreRead less
Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce ....Role of mRNA polyadenylation control in gene expression. Several benefits would come from a more complete understanding of the function of the messenger RNA poly(A) tail. It is frequently targeted by mechanisms that control cellular protein synthesis. This is most evident in developmental biology, where tail length control regulates maternal mRNA expression. Our previous work suggests that it has much wider importance for cellular function than previously thought and thus its study will produce knowledge of broad relevance to modern life sciences and its applications in medicine and biotechnology. Finally, a better understanding of yeast cellular biology is of benefit to the food and biotechnology sector of industry.Read moreRead less
How ribosomal protein loss affects cell fate. This project aims to challenge the dogma that the ribosome behaves only as a ‘‘house-keeper’’. Ribosomal protein (RP) mutations should, and often do, result in reduced cell growth and stunted animal development. Depletion of RPs in Drosophila blood cells impair stem cells and cause massive tissue overgrowth. This suggests RPs are involved in cell fate determination, which this project will research using genetic models. As ribosomal function is funda ....How ribosomal protein loss affects cell fate. This project aims to challenge the dogma that the ribosome behaves only as a ‘‘house-keeper’’. Ribosomal protein (RP) mutations should, and often do, result in reduced cell growth and stunted animal development. Depletion of RPs in Drosophila blood cells impair stem cells and cause massive tissue overgrowth. This suggests RPs are involved in cell fate determination, which this project will research using genetic models. As ribosomal function is fundamental to the development of all living organisms, this work could have wide implications for understanding all biology – from microbes, insects and plants to humans.Read moreRead less
Mediator: a new concept for controlled gene expression in plant biotechnology. The Mediator protein complex is a new control point for the activation of all genes in higher organisms and the purpose of this project is to understand how three Mediator subunits regulate disease resistance in plants. The outcomes provide a new concept to direct natural gene expression towards robust crop plants able to cope with climatic variations.