Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less
Multi-service assessment of intertidal treatment wetlands. This project aims to investigate the use of constructed intertidal wetlands to reduce nitrogen pollution while providing co-benefits including carbon sequestration and biodiversity. This research will generate a holistic assessment of the services, disservices, and cost-effectiveness of intertidal treatment wetlands compared to traditional wastewater treatment approaches. Expected outcomes include a full-scale multi-disciplinary environm ....Multi-service assessment of intertidal treatment wetlands. This project aims to investigate the use of constructed intertidal wetlands to reduce nitrogen pollution while providing co-benefits including carbon sequestration and biodiversity. This research will generate a holistic assessment of the services, disservices, and cost-effectiveness of intertidal treatment wetlands compared to traditional wastewater treatment approaches. Expected outcomes include a full-scale multi-disciplinary environmental and economic assessment of a constructed treatment wetland in a new urban development, providing industry and government partners the knowledge required to broaden uptake of intertidal wetlands as a cost-effective solution to growing levels of coastal anthropogenic pollution.Read moreRead less
A balancing act: Resolving coastal wetland water, carbon and solute fluxes. Coastal wetlands offer an impressive capacity to regulate the Earth’s climate by altering the way carbon dioxide is extracted from the atmosphere and stored while simultaneously influencing the water cycle, thus providing ecosystem services such as carbon storage, abating flood waters, improving water quality and protecting the coastline from sea level rise. This project aims to address the current gaps in understanding .... A balancing act: Resolving coastal wetland water, carbon and solute fluxes. Coastal wetlands offer an impressive capacity to regulate the Earth’s climate by altering the way carbon dioxide is extracted from the atmosphere and stored while simultaneously influencing the water cycle, thus providing ecosystem services such as carbon storage, abating flood waters, improving water quality and protecting the coastline from sea level rise. This project aims to address the current gaps in understanding the critical exchanges of water and greenhouse gases (GHGs) combining field methodologies and hydrological models, under different climatic conditions. The intended outcomes will benefit management of GHG emissions, coastal flooding and vulnerable groundwater dependent habitats.Read moreRead less
Smart micro learning with open education resources. This project aims to enhance personalised learning systems for mobile device users . Open online education is gaining in popularity with its ease of use. The project tackles the problems in relation to more and more popular mobile and ‘micro learning’, where people learn on the move and within small units of time. Ontology and machine learning technologies used in this project will help to optimise the offering of open education resources, by p ....Smart micro learning with open education resources. This project aims to enhance personalised learning systems for mobile device users . Open online education is gaining in popularity with its ease of use. The project tackles the problems in relation to more and more popular mobile and ‘micro learning’, where people learn on the move and within small units of time. Ontology and machine learning technologies used in this project will help to optimise the offering of open education resources, by providing solutions meeting each individual learner’s needs. The main outcome will consolidate a cloud based micro learning framework through integrating a group of novel algorithms.Read moreRead less
A Socially Conscious Smart IoT Platform for Water Quality Monitoring. This project will develop an intelligent remote water quality monitoring platform based on a new sensor network architectural paradigm. Expected outcomes include an artificially intelligent water quality monitoring system that is produced via a unique social enterprise business model. This approach will facilitate widespread remote water quality monitoring, leading to an enhanced understanding of the environment, whilst provid ....A Socially Conscious Smart IoT Platform for Water Quality Monitoring. This project will develop an intelligent remote water quality monitoring platform based on a new sensor network architectural paradigm. Expected outcomes include an artificially intelligent water quality monitoring system that is produced via a unique social enterprise business model. This approach will facilitate widespread remote water quality monitoring, leading to an enhanced understanding of the environment, whilst providing valuable training/education for the community stakeholders involved in the production of the system. The research outcome will be globally significant, enabling end users to meet key water quality objectives over time, and considerably increase productivity in the Australian agriculture/aquaculture industries.Read moreRead less
Testing the importance of large-scale climate factors to plant community assembly following land-use change. This project will examine the native plant species and functional diversity of Australia's rain forest communities to create a predictive framework of how plant communities recover following deforestation. Such a framework is key to focusing conservation efforts in degraded and multi-use landscapes.
ARC Centre of Excellence for Integrative Brain Function. The Centre of Excellence for Integrative Brain Function will address one of the greatest scientific challenges of the 21st century to understand how the brain works. We will investigate complex functions such as attention, prediction and decision-making, which require the coordination of information processing by many areas of the brain. This will require a highly collaborative approach involving neurobiologists, cognitive scientists, eng ....ARC Centre of Excellence for Integrative Brain Function. The Centre of Excellence for Integrative Brain Function will address one of the greatest scientific challenges of the 21st century to understand how the brain works. We will investigate complex functions such as attention, prediction and decision-making, which require the coordination of information processing by many areas of the brain. This will require a highly collaborative approach involving neurobiologists, cognitive scientists, engineers and physicists, allowing us to translate our discoveries into novel technologies for the social and economic benefit of all Australians. We will also train a new generation of multidisciplinary researchers, and contribute our expertise to a range of public education and awareness programs.Read moreRead less
Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence ....Ecosystem resilience of Shark Bay under changing ocean climate. This project aims to investigate the resilience of the Shark Bay World Heritage Site to projected climate change. This project will generate new knowledge for marine conservation through analyses of habitat loss on nutrient budgets and productivity in seagrass and microbialite ecosystems. Expected outcomes are an improved understanding of climate-driven shifts on ecosystem processes in Shark Bay, incorporating science-based evidence for better conservation and management. This will provide significant benefits by contributing to the future-proofing of Shark Bay’s World Heritage values to climate change, and more broadly by demonstrating the consequences of the continued tropicalisation of Australia’s coastline.Read moreRead less
Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster re ....Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster reef restoration that can be integrated into management and policy. This project should provide significant benefits, such as the development of key strategic alliances to enhance management of estuaries, and reestablish the environmental, economic and social benefits of oyster reefs.Read moreRead less