Discovery Early Career Researcher Award - Grant ID: DE200101708
Funder
Australian Research Council
Funding Amount
$406,821.00
Summary
New directions for using brain stimulation to understand brain function. Neuroplasticity is of fundamental importance to brain function as it mediates learning, memory and development. Deficits in neuroplasticity are observed in a number of neurological conditions and thought to contribute to cognitive dysfunction. This study is designed to develop a better understanding of the neurochemical and genetic factors impacting on neuroplasticity. In addition, it aims to (i) upregulate brain connectivi ....New directions for using brain stimulation to understand brain function. Neuroplasticity is of fundamental importance to brain function as it mediates learning, memory and development. Deficits in neuroplasticity are observed in a number of neurological conditions and thought to contribute to cognitive dysfunction. This study is designed to develop a better understanding of the neurochemical and genetic factors impacting on neuroplasticity. In addition, it aims to (i) upregulate brain connectivity in a precise and targeted manner, (ii) elicit functional increases in cognitive performance and (iii) demonstrate the relationship between functional connectivity and cognition. Outcomes include a better understanding of plasticity in the brain & a enhanced capacity to examine and modulate brain plasticity.Read moreRead less
What is the functional significance of mirror neurons? Contrasting the adaptation and association models of the mirror neuron system. Mirror neurons are a type of brain cell that are thought to underlie empathy and cause autism. Alternatively, however, mirror neurons might instead arise from repeated associations between what we see and what we do. This study uses brain stimulation and neuroimaging techniques to determine the function of mirror neurons.
Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the ....Multimodal testing for a fast subcortical route for salient visual stimuli. This project aims to uncover links between underlying brain circuitry, uncertainty and consciousness, and perceptions of fear. The project will use a multi-modal combination of brain imaging and neural recording techniques to generate new knowledge about the brain’s processing of biologically relevant information. The expected outcomes will enhance our knowledge of how the brain rapidly and non-consciously prepares the body for potential escape behaviours and of the brain pathways engaged in fear perception. The outcomes have the potential to inform strategies for overcoming anxiety and its effects on daily life, social interactions and workplace productivity.Read moreRead less
Cannabis and the brain: the good, the bad and the unknown. Cannabis is the most widely used illicit drug but much remains unknown about how it affects the brain. This research will examine effects on brain cells through to whole brain function in humans to determine how cannabis use may lead to impaired thinking or psychological symptoms and why cannabis might affect individuals in different ways.
Neural network underlying memory erasure. Memory expression can easily be reduced through the process of extinction, which involves repeated presentations of cues involved in that memory but without any outcome. In adult animals (including humans), it is widely accepted that extinction leads to a temporary inhibition of the original memory that remains largely unaltered. Remarkably, extinction causes erasure in juvenile rodents so that the original memory is permanently reduced. This is because ....Neural network underlying memory erasure. Memory expression can easily be reduced through the process of extinction, which involves repeated presentations of cues involved in that memory but without any outcome. In adult animals (including humans), it is widely accepted that extinction leads to a temporary inhibition of the original memory that remains largely unaltered. Remarkably, extinction causes erasure in juvenile rodents so that the original memory is permanently reduced. This is because the normal maturational changes in the brain result in fundamental developmental differences in the neural network underlying extinction. This project aims to map out this network across life, and also to reproduce the juvenile network in adult rats to erase memories via extinction in adulthood.Read moreRead less
Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised e ....Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised effects of brain stimulation on the ageing brain. The outcomes of this research could significantly improve understanding of brain ageing, and advance the fields of systems neuroscience, network science, and brain stimulation.Read moreRead less
Suicide prevention and management of deliberate self-harm: randomised control trial of an assertive engagement, brief psychotherapy and community linkage model. Suicide is the second commonest cause of death by injury in Australia. Suicide prevention is an important public health priority but rates remain high. People who have previously attempted suicide are most likely to kill themselves. Most suicidal people attend emergency departments where they get inadequate treatment for their psychologi ....Suicide prevention and management of deliberate self-harm: randomised control trial of an assertive engagement, brief psychotherapy and community linkage model. Suicide is the second commonest cause of death by injury in Australia. Suicide prevention is an important public health priority but rates remain high. People who have previously attempted suicide are most likely to kill themselves. Most suicidal people attend emergency departments where they get inadequate treatment for their psychological and social problems and remain depressed and suicidal. This project will test the effectiveness of a new psychological and social treatment to reduce the depression and link suicidal people with community supports. If successful, this treatment could be provided in any emergency department and help decrease suicide rates in Australia.Read moreRead less
Whether social media literacy mitigates effects of social media in adolescents. This project aims to determine protective and risk factors for problems associated with social media use in early adolescents. In particular, it aims to determine the protective role of social media literacy (the skill to analyse, critique and evaluate social media posts). Although most Australian adolescents use social media, frequent social media engagement and photo-based activities can cause body dissatisfaction, ....Whether social media literacy mitigates effects of social media in adolescents. This project aims to determine protective and risk factors for problems associated with social media use in early adolescents. In particular, it aims to determine the protective role of social media literacy (the skill to analyse, critique and evaluate social media posts). Although most Australian adolescents use social media, frequent social media engagement and photo-based activities can cause body dissatisfaction, disordered eating and compromised well-being. Findings supporting a protective role for social media literacy are expected to inform policy to improve adolescent well-being and pave the way for school-based social media literacy interventions.Read moreRead less
Improving the retention rate for residential treatment of substance abuse by sequential intervention for social anxiety. Alcohol and other drug use is a major social and medical problem, costing the Australian community an estimated $7.6 billion annually. Mental health disorders have been closely linked with increased illicit drug use and physical health problems. Social anxiety (SAD) is highly prevalent amongst individuals presenting with drug and alcohol use disorders. Evidence suggests that ....Improving the retention rate for residential treatment of substance abuse by sequential intervention for social anxiety. Alcohol and other drug use is a major social and medical problem, costing the Australian community an estimated $7.6 billion annually. Mental health disorders have been closely linked with increased illicit drug use and physical health problems. Social anxiety (SAD) is highly prevalent amongst individuals presenting with drug and alcohol use disorders. Evidence suggests that social anxiety symptoms may be responsible for promoting excessive drug use and may be a particularly influential factor in poor treatment retention rates and promoting relapse. Thus, the focus on improving treatment outcomes for individuals with comorbid anxiety and drug use disorders represents an area of considerable importance both nationally and internationally.Read moreRead less
Body image instability, disordered eating and muscle dysmorphia. Body image is a serious public health issue. Dissatisfaction with body shape promotes disordered eating in females who fast and purge to lose weight, and muscle dysmorphia in males who over-exercise and use steroids to gain muscle. We will test the idea that these psychological disorders stem from an unstable body image. Our research will reveal the fundamental risk factors associated with disordered eating and muscle dysmorphia an ....Body image instability, disordered eating and muscle dysmorphia. Body image is a serious public health issue. Dissatisfaction with body shape promotes disordered eating in females who fast and purge to lose weight, and muscle dysmorphia in males who over-exercise and use steroids to gain muscle. We will test the idea that these psychological disorders stem from an unstable body image. Our research will reveal the fundamental risk factors associated with disordered eating and muscle dysmorphia and allow us to identify at-risk individuals on the basis of their body image instability. It will also predict patients' amenability to treatments that target body image, thereby improving outcomes for these individuals.Read moreRead less