Feasibility Of Implementing Precision Medicine For The Treatment Of Metastatic Melanoma
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Melanoma is the most aggressive form of skin cancer, accounting for 75% of skin cancer deaths in Australia. When it progresses to stage IV disease, patient prognosis is poor, with less than 10% of cases surviving to 5 years. The goal of this project is to determine whether drugs currently used to treat different diseases could also be used to treat melanoma patients and improve their survival, particularly those that do not respond in current clinical trials.
Stratification Of Therapies In HNSCC Through Discovery Of Molecular Signatures
Funder
National Health and Medical Research Council
Funding Amount
$852,600.00
Summary
Human head and neck cancer is a devastating disease with poor survival rates. Using a unique mouse model, we have now uncovered novel genetic defects that trigger cancer development. These defects are also evident in human cancers. This proposal will utilize this mouse model to explore new treatment strategies based on targeting the genetic defect. Ultimately we anticipate that this will translate into personalized therapies that will favourably alter the course of this cancer.