Decoding Mechanisms Of Brain-intestinal Communication
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Obesity is a worldwide concern to human health. Research into how fat is regulated in the body may provide new therapeutic options. It is not well understood how signals from the brain control fat storage. We have recently identified a gene that is important for the communication between the brain and the intestine in the control of fat levels. As such, our work will enable us to better understand this phenomenon.
Vesicular Trafficking Pathways Underpinning Neuronal Secretion And Survival
Funder
National Health and Medical Research Council
Funding Amount
$697,209.00
Summary
Plethora of diseases of the nervous system are caused by defects in vesicular trafficking including neurodegenerative diseases such as Alzheimer’s disease. I will explore the mechanisms underpinning synaptic vesicular trafficking using novel super resolution techniques and reveal the how secretory vesicles traffic to the plasma membrane, undergo exocytosis, and recycle. I will also explain how in the crowded environment of the presynaptic terminals, retrograde cargoes are transported back to the ....Plethora of diseases of the nervous system are caused by defects in vesicular trafficking including neurodegenerative diseases such as Alzheimer’s disease. I will explore the mechanisms underpinning synaptic vesicular trafficking using novel super resolution techniques and reveal the how secretory vesicles traffic to the plasma membrane, undergo exocytosis, and recycle. I will also explain how in the crowded environment of the presynaptic terminals, retrograde cargoes are transported back to the cell body thereby carrying survival signals.Read moreRead less