Statistical Methods For Identifying Structural Variation In Tumour Genomes Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$243,458.00
Summary
New DNA sequencing technology can sequence a tumour genome affordably in 2 weeks. This re-sequencing data can be used to find small mutations and large-scale chromosomal rearrangements that together are the drivers of cancer. These may one day be used to guide cancer therapy. This project will develop new algorithms for finding mutations and apply these to discover the genetic basis of drug resistance in a model lymphoma system.
Detection Of Somatic Mutations In Sporadic Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$1,256,166.00
Summary
Finding genetic causes of epilepsies is essential for refining treatments and genetic counseling. Genetic mutations may occur after fertilization (somatic mutations). These can be difficult to detect by routine genetic tests. We aim to identify somatic mutations by: very deep sequencing of blood to find low concentrations of mutations, analysing DNA from the cerebrospinal fluid, and analysing DNA obtained from the back of the nose which is closely related to brain tissue.
Discovery Early Career Researcher Award - Grant ID: DE200100544
Funder
Australian Research Council
Funding Amount
$418,810.00
Summary
Reconnecting the Histories of Papuan, Australian and Oceanic Seascapes . This project aims to investigate connections between Papuan, Australian and Oceanic seascapes created by a westward expansion by Lapita seafarers 3000 years ago. The project raises and addresses new questions about the maintenance of regional social relationships with an innovative archaeological approach that focuses on the edges of cultural domains where people met and shared ideas. Expected outcomes include enhanced rese ....Reconnecting the Histories of Papuan, Australian and Oceanic Seascapes . This project aims to investigate connections between Papuan, Australian and Oceanic seascapes created by a westward expansion by Lapita seafarers 3000 years ago. The project raises and addresses new questions about the maintenance of regional social relationships with an innovative archaeological approach that focuses on the edges of cultural domains where people met and shared ideas. Expected outcomes include enhanced research collaborations and improved regulatory capacity. Reconnecting seascapes is expected to inform and benefit academic and government responses to heritage conservation and align with Australian Government aspirations to conserve regional cultural heritage and enable economic development through strategic collaboration.Read moreRead less
A Worldwide Study Of Cancer Risk For Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$710,761.00
Summary
People with the genetic Lynch syndrome are more likely to get cancer but we cannot accurately predict who will get cancer and when. Doctors need this information to improve cancer prevention. Large collaborative studies are needed for this research. We have agreement from the 115 researchers to combine, into a single resource, 8,863 family trees of Lynch syndrome. We will analyse this data to determine the risk of cancer and whether it differs by sex, age, or nationality.
Rehearsals in Colonialism: Tracking Transpacific Expressions of Indigenous and Settler Sovereignty, 1788-1900. In the 1800s a spate of Pacific monarchies declared pre-emptive independence amidst the upheavals of circling imperial interest. Kingdoms in Tonga, Hawai'i, and New Zealand lasted at least a century, but only years in Tahiti, Samoa and Fiji. Nevertheless they epitomised uncertain times when Indigenous and settler peoples alike focussed intensely on the sovereign status of subject people ....Rehearsals in Colonialism: Tracking Transpacific Expressions of Indigenous and Settler Sovereignty, 1788-1900. In the 1800s a spate of Pacific monarchies declared pre-emptive independence amidst the upheavals of circling imperial interest. Kingdoms in Tonga, Hawai'i, and New Zealand lasted at least a century, but only years in Tahiti, Samoa and Fiji. Nevertheless they epitomised uncertain times when Indigenous and settler peoples alike focussed intensely on the sovereign status of subject peoples in subject colonies. This project connects these moments of sovereignty for the first time in a unique opportunity to track the intellectual and social histories of contact in the transcolonial space of the Pacific and its settler colonial rim. Project outcomes will offer new insight into our colonial past and its legacies in the present.Read moreRead less
Dimensions of value: Understanding the role and meaning of shell valuables in the Melanesian past and present. Shell valuables are fundamentally important in many Melanesian societies, linking people to each other, the land and their ancestors. Although shell artefacts are frequent in Melanesian archaeological sites, presently it is not possible to discriminate between types and levels of value. Through ethnoarchaeological enquiry in the Solomon Islands and intensive studies of museum ethnograph ....Dimensions of value: Understanding the role and meaning of shell valuables in the Melanesian past and present. Shell valuables are fundamentally important in many Melanesian societies, linking people to each other, the land and their ancestors. Although shell artefacts are frequent in Melanesian archaeological sites, presently it is not possible to discriminate between types and levels of value. Through ethnoarchaeological enquiry in the Solomon Islands and intensive studies of museum ethnographic collections, this project aims to develop tools to allow archaeologists to better interpret the nature of different shell artefacts and the social contexts of their production, use and discard. In doing so, it will enhance understandings of Melanesian societies and their transformations through time.Read moreRead less
Before, during and after Lapita: 5000 years of cultural continuity and transformation at Caution Bay, southern Papua New Guinea. Australia's closest Indigenous neighbours in southern Papua New Guinea have long been thought to have been in contact with long-distance seafarers only in the last 2000 years. This project will document recent archaeological findings that are causing a radical rethink of ancestral connections between Australia and southern Papua New Guinea.
A Functional Assay To Classify Genetic Variants In Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$368,195.00
Summary
At least one person in every 1000 is affected by Lynch syndrome, in which faulty DNA repair machinery causes high rates of cancer. People with Lynch syndrome can have their risk of cancer cut substantially with regular screening. However, we often struggle to understand whether people with 'non-standard' DNA sequences in particular genes actually have Lynch syndrome. This project develops a simple test that will tell clinicians whether a given sequence change relates to Lynch syndrome or not.
Digital Death and Immortality. This project will create a philosophically-informed ethical approach for managing the 'digital remains' of internet users who have died. Emerging artificial intelligence technologies make it possible to reuse and interact with these digital remains. This offers new ways of commemorating the dead and for managing grief. Yet these technologies also threaten to exploit the dead and to change our relationship to them in troubling ways. Expected outcomes of the project ....Digital Death and Immortality. This project will create a philosophically-informed ethical approach for managing the 'digital remains' of internet users who have died. Emerging artificial intelligence technologies make it possible to reuse and interact with these digital remains. This offers new ways of commemorating the dead and for managing grief. Yet these technologies also threaten to exploit the dead and to change our relationship to them in troubling ways. Expected outcomes of the project include guidance for the ethical use of these technologies and policy recommendations for regulating the reuse of digital remains. This will provide significant benefits by helping Australia to avoid the ethical dangers inherent in emerging technologies of 'digital reanimation.'Read moreRead less
Australian Fiction 1989 to 2005, and its National and Global Infrastructures. This project is a systematic analysis of Australian fiction published between 1989 and 2005: after the Australian Bicentenary and into the new millenium. It will look in particular at the relationship between national literary culture and globalisation. It examines the cultural, social, educational, political and economic aspects of this literary field, and accounts for its production and distribution, as well as the w ....Australian Fiction 1989 to 2005, and its National and Global Infrastructures. This project is a systematic analysis of Australian fiction published between 1989 and 2005: after the Australian Bicentenary and into the new millenium. It will look in particular at the relationship between national literary culture and globalisation. It examines the cultural, social, educational, political and economic aspects of this literary field, and accounts for its production and distribution, as well as the ways in which it is evaluated and put to use. It will be the first study of its kind, an analysis of contemporary Australian literary production in the fullest sense.Read moreRead less