Molecular Markers Of Phenotype, Therapeutic Responsiveness And Prognosis In Human Cancers.
Funder
National Health and Medical Research Council
Funding Amount
$11,762,117.00
Summary
This proposal aims to identify molecular markers that can be used to classify subtypes of particular cancers according to their prognosis and response to therapy. This will optimise selection of patients for the most appropriate treatment and lead to the development of new therapeutic strategies.
Circulating Tumour DNA To Monitor Treatment Response And Resistance In Chronic Lymphocytic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$876,950.00
Summary
Many cancers shed small amounts of DNA (ctDNA) into the patient’s bloodstream and recent advances in genomic technologies now allow levels of ctDNA to be accurately measured in the blood. Changes in ctDNA levels have potential to be used as specific markers of disease progression and/or response to cancer therapy. This project will evaluate if ctDNA can be used to monitor treatment responses and individualise treatment decisions in patients with chronic lymphocytic leukaemia.
New Electronic Archives for Australian Literature. Information capacity in Australian literary studies has been dramatically expanded by national investment in electronic archives, while trends in the discipline increasingly demand empirical support for claims about literary history and literary value. At the same time, research about Australian literature remains primarily theoretical, insufficiently informed by newly available data. This project aims to further enrich the new data sets, and to ....New Electronic Archives for Australian Literature. Information capacity in Australian literary studies has been dramatically expanded by national investment in electronic archives, while trends in the discipline increasingly demand empirical support for claims about literary history and literary value. At the same time, research about Australian literature remains primarily theoretical, insufficiently informed by newly available data. This project aims to further enrich the new data sets, and to use them in an innovative return to the classical issues in Australian literary criticism and history. It will provide demonstration applications of data in new electronic archives.Read moreRead less
Our Island Home: The shifting map of Australian literature. This project will provide the first full-length study of the ways Australia's unique status as an island continent has shaped its national literature. Understanding this relationship will re-define the borders of its literature in three ways: it will establish new connections within the national literature between the literature of the mainland and surrounding islands; it will identify why certain regions such as the continental interio ....Our Island Home: The shifting map of Australian literature. This project will provide the first full-length study of the ways Australia's unique status as an island continent has shaped its national literature. Understanding this relationship will re-define the borders of its literature in three ways: it will establish new connections within the national literature between the literature of the mainland and surrounding islands; it will identify why certain regions such as the continental interior and outlying islands capture the literary imagination at particular times; it will bring to light ways for Australian literature to position itself within the shifting geographies of globalised modernity. Read moreRead less
Excavating MacGregor: re-connecting a colonial museum collection. Sensing the impacts of colonisation, the first Administrator of British New Guinea William MacGregor made a significant collection of objects specifically for its future citizens. This comprehensive legacy of 13 000 objects did not remain in the country but was dispersed to three Australian and six overseas museums. Our aim is to re-assemble and re-connect this material by 'excavating' its private and official components. This res ....Excavating MacGregor: re-connecting a colonial museum collection. Sensing the impacts of colonisation, the first Administrator of British New Guinea William MacGregor made a significant collection of objects specifically for its future citizens. This comprehensive legacy of 13 000 objects did not remain in the country but was dispersed to three Australian and six overseas museums. Our aim is to re-assemble and re-connect this material by 'excavating' its private and official components. This research aims to focus on the makers and traders to disentangle the social relationships embedded in the objects. Using material-centred, assemblage-based archaeological approaches, we aim to investigate how indigenous groups used objects to negotiate with the new colonial government.Read moreRead less
The Genetic And Environmental Determinants Of Amyloid Deposition In Older Individuals: An Amyloid Imaging Study Using The Twin Design
Funder
National Health and Medical Research Council
Funding Amount
$643,267.00
Summary
Alzheimer’s disease is characterised by the deposition of amyloid plaques in the brain. We don’t fully understand how amyloid deposition occurs and what contribution is made by genetic and environmental factors. Amyloid deposition in the brain can now be quantified during life using positron emission tomography. In this study, we will examine brain amyloid in twins, which will determine what proportion of the pathology is attributable to environmental factors that may be modifiable.
Discovery Early Career Researcher Award - Grant ID: DE140100254
Funder
Australian Research Council
Funding Amount
$395,205.00
Summary
The oldest rock art in Asia and the early human occupation of island Southeast Asia. Recent research revealed that humans were producing rock paintings on the Indonesian island of Sulawesi at least 39 thousand years ago (and possibly up to 46 thousand years ago). The rock art, therefore, is essentially contemporaneous with the earliest cave art in Europe and may be the world's oldest, given the arrival of Homo sapiens in Australia at least 50 thousand years ago. This project will further investi ....The oldest rock art in Asia and the early human occupation of island Southeast Asia. Recent research revealed that humans were producing rock paintings on the Indonesian island of Sulawesi at least 39 thousand years ago (and possibly up to 46 thousand years ago). The rock art, therefore, is essentially contemporaneous with the earliest cave art in Europe and may be the world's oldest, given the arrival of Homo sapiens in Australia at least 50 thousand years ago. This project will further investigate the early rock art of Sulawesi as well as other key Indonesian islands located along likely migration routes from Borneo to New Guinea. The results will have major implications for our understanding of the cultural behaviour and dispersal of the earliest modern humans to colonise Southeast Asia and Australia.Read moreRead less
Archaeologies of community and colonialism in Oceania. This project aims to understand the colonial past, its repercussions for the present and future in Oceania and the relationships between global forces and local experiences. It will use an interdisciplinary approach to historical archaeology and community archaeology. The unique colonial landscapes in Mangareva, French Polynesia will provide a landmark case study with global implications. In addition to internationally significant scholarly ....Archaeologies of community and colonialism in Oceania. This project aims to understand the colonial past, its repercussions for the present and future in Oceania and the relationships between global forces and local experiences. It will use an interdisciplinary approach to historical archaeology and community archaeology. The unique colonial landscapes in Mangareva, French Polynesia will provide a landmark case study with global implications. In addition to internationally significant scholarly outputs and collaboration development, the project will make a substantive contribution to public outreach and education. Benefits would include advancement of Oceanic contributions to global historical archaeology, and increased awareness of the meanings of colonial heritage among Pacific peoples.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101731
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Oceanic crossings: cultures of trans-Pacific passenger shipping in the age of steam, circa 1880-1960. This project investigates the connections between images of the Pacific, transoceanic mobility and shipboard cultures in the wake of the industrial transport revolution. It will come to a new understanding of the ways in which links were forged and sustained between Australia, the Pacific Islands and North America throughout the twentieth century.
3000 Years of settlement and interaction in southern Vanuatu. This project aims to conduct an archaeological survey of Vanuatu. One of archaeology's most significant contributions is providing models for the emergence of cultural diversity through time. Vanuatu is one of the most diverse regions on Earth. The southern islands were an important hub in early settlement and long-term inter-island interactions of Island Melanesia. Yet little is known about the origins of cultural contacts and divers ....3000 Years of settlement and interaction in southern Vanuatu. This project aims to conduct an archaeological survey of Vanuatu. One of archaeology's most significant contributions is providing models for the emergence of cultural diversity through time. Vanuatu is one of the most diverse regions on Earth. The southern islands were an important hub in early settlement and long-term inter-island interactions of Island Melanesia. Yet little is known about the origins of cultural contacts and diversity in the area. A major archaeological survey of the Polynesian outliers Futuna and Aniwa and neighbouring islands Tanna and Aneityum would greatly improve our knowledge of settlement patterns, long-distance exchange, and cross-cultural interaction in the region, from initial Lapita settlement 3000 years ago through to the arrival of Christian missionaries in the 1860s.Read moreRead less