Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668155
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Pl ....Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Plan for the Geosciences. Combining seismic and electromagnetic methods will provide both geochemeical and geophysical constaints, e.g., on zones of alteration and shear with the potential for deep mineralisation. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100095
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
Frontiers in integrated laser-sampled trace-element and isotopic geoanalysis. Until around 2005 Australia was a leader in the coupling of laser-ablation microprobes (LAM) with inductively-coupled-plasma mass spectrometers (ICPMS) for geochemical research. However, international developments in femtosecond LAM, sector field instruments and novel instrument coupling possibilities have leap-frogged these achievements. The proposed innovative facility will allow us to regain the leading edge in thi ....Frontiers in integrated laser-sampled trace-element and isotopic geoanalysis. Until around 2005 Australia was a leader in the coupling of laser-ablation microprobes (LAM) with inductively-coupled-plasma mass spectrometers (ICPMS) for geochemical research. However, international developments in femtosecond LAM, sector field instruments and novel instrument coupling possibilities have leap-frogged these achievements. The proposed innovative facility will allow us to regain the leading edge in this field, help maintain the high profile of Australian geoscience internationally, and to attract high-quality researchers and industry-related research funding. The research is relevant to the Deep Earth Resources National Priority and will include projects of direct relevance to mineral exploration and process technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989920
Funder
Australian Research Council
Funding Amount
$750,000.00
Summary
Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a c ....Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a current unmet need for scientists in this country and will provide cutting-edge technologies to Australian researchers so they can better detect, understand, and treat human, animal and plant diseases and the environmental impact of climate change.Read moreRead less
The biosynthesis of structural proteins in parasites. The socio-economic impact of parasitic diseases, in Australia and throughout the world, is enormous- they kill 2-3 million people per year and cost livestock industries billions of dollars per annum. Some are serious food and waterborne threats, such as the coccidia, because they are transmitted from person-to-person via the faecal-oral route, or via ingestion of contaminated water or food, or through the ingestion of cysts in raw or underco ....The biosynthesis of structural proteins in parasites. The socio-economic impact of parasitic diseases, in Australia and throughout the world, is enormous- they kill 2-3 million people per year and cost livestock industries billions of dollars per annum. Some are serious food and waterborne threats, such as the coccidia, because they are transmitted from person-to-person via the faecal-oral route, or via ingestion of contaminated water or food, or through the ingestion of cysts in raw or undercooked meat. They cause diarrhoea, which in some cases, can be life-threatening. We will understand how the coccidia protect themselves as they move from host to host and, through that understanding, develop new ways to control them and eliminate the suffering caused by parasitic diseases.Read moreRead less
Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. L ....Parasite virulence: the role of activation and suppression of P2X7 receptors. Toxoplasmosis and leishmaniasis pose a threat to the health and well-being of the Australian human and animal populations. Around 6-8 million Australians are infected with Toxoplasma, a parasite that can cause severe problems in immunosuppressed individuals and birth defects and miscarriage in pregnant women with a primary infection. Toxoplasmosis is also the main cause of abortion and stillbirth in Australian sheep. Leishmaniasis, recently found in Australia, is a risk for overseas travellers, livestock and wildlife. This research will provide an understanding of what makes these parasites successful, paving the way for development of novel drugs to combat these chronic diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775533
Funder
Australian Research Council
Funding Amount
$700,000.00
Summary
A New Generation Noble Gas Mass Spectrometer Facility for Advanced Research in the Earth, Planetary and Environmental Sciences. The current proposal, to establish a new Noble Gas Analytical Consortium for noble gas chronological and geochemical analyses, will generate new knowledge on the evolution of the Earth, with profound implications for past climate change, landscape evolution, formation of ore bodies, and terrestrial geodynamics. Consequently, the facility will conform to the National Res ....A New Generation Noble Gas Mass Spectrometer Facility for Advanced Research in the Earth, Planetary and Environmental Sciences. The current proposal, to establish a new Noble Gas Analytical Consortium for noble gas chronological and geochemical analyses, will generate new knowledge on the evolution of the Earth, with profound implications for past climate change, landscape evolution, formation of ore bodies, and terrestrial geodynamics. Consequently, the facility will conform to the National Research Priority of 'An Environmentally Sustainable Australia'. The new facility will ensure that Australian research remains at the forefront of international science development and will also provide essential training for the next generation of Australian scientists.Read moreRead less
The Role And Inheritance Of Constitutional Epimutations In Early-onset Colorectal Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$347,551.00
Summary
Traditionally familial cancers are thought to be caused by spelling mistakes within the genetic code of cancer prevention genes. Our group has found that chemical attachments to one gene (MLH1) stops it working, even where there is no spelling mistake, and that those chemical changes can be inherited in families with bowel cancer. We will determine how frequently this type of defect occurs in bowel cancer patients, how and why it arises, and if other cancer genes are similarly affected.
Male Chlamydia Infections: The Key Role Of Macrophages In Testicular Dissemination And Disrupted Spermatogenesis
Funder
National Health and Medical Research Council
Funding Amount
$868,464.00
Summary
Male partners of couples seeking IVF, who are seropositive for Chlamydia, indicating a prior infection, often have significantly impaired sperm quality (reduced motility, increased DNA damage and abnormal sperm morphology). Our studies will define how Chlamydia are transported to the testis from the penis and how chronic chlamydial infection in the testis disrupts sperm development. We will also develop new antibiotic delivery systems to improve treatment of male chlamydial infections.
Global Lithosphere Architecture Mapping. Compositional domains in the subcontinental lithospheric mantle reflect the processes of continental assembly and breakup through Earth's history. Their boundaries may focus the fluid movements that produce giant ore deposits. Mapping these boundaries will provide fundamental insights into Earth processes and a basis for the targeting of mineral exploration. We will integrate mantle petrology, tectonic synthesis and geophysical analysis to produce the f ....Global Lithosphere Architecture Mapping. Compositional domains in the subcontinental lithospheric mantle reflect the processes of continental assembly and breakup through Earth's history. Their boundaries may focus the fluid movements that produce giant ore deposits. Mapping these boundaries will provide fundamental insights into Earth processes and a basis for the targeting of mineral exploration. We will integrate mantle petrology, tectonic synthesis and geophysical analysis to produce the first maps of the architecture of the continental lithosphere, to depths of ca 250 km. These maps will provide a unique perspective on global dynamics and continental evolution, and on the relationships between lithosphere domains and large-scale mineralisation.Read moreRead less