Investigating B Cell Development, Maintenance And High-affinity Antibody Production By ENU Mutagenesis
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
B cells are essential for the protection against infections. This application aims to identify new genes that are crucial for the development or function of B cells and will investigate how mutations in newly discovered genes contribute to defects in the development and function of B cells and the pathogenesis of B cell leukaemia.
Mechanisms Of Glucocorticoid Resistance In Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$547,970.00
Summary
Glucocorticoids are extremely active drugs used in the treatment of childhood acute lymphoblastic leukaemia (ALL), yet a proportion of patients respond poorly to therapy and exhibit resistance at relapse. Clinically relevant mechanisms of glucocorticoid resistance are poorly understood, principally due to lack of appropriate experimental models. This project will reveal novel mechanisms of drug resistance in childhood leukaemia and lead to novel therapeutic strategies to improve outcome.
How Does NF-kB2 Regulate Thymic Selection To Prevent Organ-specific Autoimmune Disease?
Funder
National Health and Medical Research Council
Funding Amount
$787,600.00
Summary
Autoimmune diseases like type 1 diabetes and thyroiditis arise from defects that cause the immune system to confuse self and non-self. Normally, this distinction is programmed in the thymus. We recently identified the gene that causes a form of autoimmune disease. We also made an important discovery about how the thymus gland regulates self-non-self discrimination. We will build on these two discoveries to gain a precise understanding of how the immune system normally avoids autoimmune disease.
Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
Regulation Of Haemopoietic And Immune Cells In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$19,924,984.00
Summary
This Program brings together a team of researchers with world-class multidisciplinary skills in biomedical discovery and an established track record of clinical and commercial translation of research discoveries. This Program will result in the creation of new knowledge regarding the control of blood and immune cell production and function and provide new avenues for the treatment of people suffering from cancers of the blood, inflammatory and immune disorders.
It is feasible to sequence patient genomes but we need to know more about how genetic variants cause complex disease. We have sequenced genomes from patients with immune deficiency and will test the idea that genetic variation causes consistent changes in particular white blood cells, thus providing a bridge between genomic information and clinical diagnosis. Outcomes will include more accurate diagnosis, better understanding of immunity, and a strategy for using whole genome information.
Two-Eyed Seeing – A Framework For Cultural Fishery Assessments Supporting Equitable And Sustainable Access To Shared Resources In NSW Inland Rivers
Funder
Fisheries Research and Development Corporation
Funding Amount
$1,460,500.00
Summary
Fish are totemic and a primary food source; and so are part of the deep cultural, spiritual and economic connections Aboriginal communities have to their waterways that are part of ‘Country’. Cultural knowledge tells us that when there’s more water availability cultural fishers experience increased total catches and greater diversity of target species, and they fish more (e.g. increase in recreational and subsistence fishing). These narratives also suggest that as a result of these improved cult ....Fish are totemic and a primary food source; and so are part of the deep cultural, spiritual and economic connections Aboriginal communities have to their waterways that are part of ‘Country’. Cultural knowledge tells us that when there’s more water availability cultural fishers experience increased total catches and greater diversity of target species, and they fish more (e.g. increase in recreational and subsistence fishing). These narratives also suggest that as a result of these improved cultural fishing opportunities, there are flow on socio-economic benefits to household budgets, diets of communities, social behaviours and mental health and well-being.
Water is sacred and living; and central to the cultural, social and spiritual identity of Aboriginal people, as well as to their livelihoods. Conceptual models underpinning western water management frameworks and decision making do not incorporate Aboriginal/First Nations socio-cultural complexity, local knowledge and governance arrangements. These are critical – Aboriginal/First Nations people have strong connections with fish, water, rivers and knowledge to contribute to planning, as well as a fundamental right to participate. Water and fish are central to the way of life, two-way knowledge and planning frameworks will support reciprocity in engagement and participation.
Two-Eyed Seeing Frameworks (Ganma, Yolgnu for two-ways) provide a way forward for cultural fishery assessments supporting equitable and sustainable access to shared resources. In this framework, knowledge systems (western and cultural) contribute in parallel, on an equal footing, and both serve as evidence bases to produce an enriched picture of mutual understanding. Application of this framework can empower Aboriginal communities to participate more equitably and negotiate by using their science and values and providing a method for inclusion.
The overall objective of this proposed project is to empower Aboriginal communities through application of a “Two-Eyed seeing framework” (Reid et al. 2020) to participate more equitably and negotiate for cultural fishing practices and water allocation and management. This project will define the cultural fishery and quantify the socio-economic value of cultural fishing in two NSW river regions, and assist communities to identify water management needs for key cultural fish species to support ongoing planning and negotiations. It will improve our current fishery and water management by providing a pathway for cultural fisheries and cultural science to be included. Overall, it will increase our current knowledge of fish and fisheries, by bridging the gap between cultural science and western science practitioners and knowledge holders to share understandings, insights and skills. The application and extension of this framework to a national project will be considered for future use in addressing cultural fishery allocations and management.
Objectives: 1. Identify suitable NSW riverine cultural fisheries, engage with Aboriginal Communities, Traditional Owners, codesign the project and confirm move to phase 2. 2. Define and quanitfy the cultural fishery and associated totemic, cultura and social values 3. Identify and describe fish objectives and water management needs for cultural fish species using the Fish and Flows Framework. 4. Determine if changes in (2) are related to changes in water availability, policy and operations and/or river restoration activities (e.g. fish passage restoration, cold water passage, screening), if possible. 5. Objectively assess the efficacy and utility of the “Two-Eyed Seeing framework” in assessing the totemic, culutal and social fishing values and linking them to the fish and flows framework, including consideration of National applicability. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less