Diatom frustules: nanostructures at the base of ocean food webs. Molecules interacting with surfaces are fundamental to biological, chemical and physical processes, including desalinization membrane design, lab-on-a-chip systems, industrial catalysis, bioremediation, neurophysiology and uptake of nutrients for incorporation into food webs. Here, we use diatoms as models for molecule-surface interactions to find basic principles that underlay all of these interactions. This research will train st ....Diatom frustules: nanostructures at the base of ocean food webs. Molecules interacting with surfaces are fundamental to biological, chemical and physical processes, including desalinization membrane design, lab-on-a-chip systems, industrial catalysis, bioremediation, neurophysiology and uptake of nutrients for incorporation into food webs. Here, we use diatoms as models for molecule-surface interactions to find basic principles that underlay all of these interactions. This research will train students and scientists and establish collaborations with leading international scientists in the field.Read moreRead less
Physical and Ecological Structure at the Base of Ocean Food Webs. The coastal ocean is a crucial resource to Australia. In founding a research area on coastal food web function we provide international scientific leadership, train scientists in a cutting edge area, and lay the foundation for improved management of fisheries, aquaculture and species invasions. This work boosts Australia's participation in the International Polar Year, and knowledge about Antarctic Territorial waters. Infrastructu ....Physical and Ecological Structure at the Base of Ocean Food Webs. The coastal ocean is a crucial resource to Australia. In founding a research area on coastal food web function we provide international scientific leadership, train scientists in a cutting edge area, and lay the foundation for improved management of fisheries, aquaculture and species invasions. This work boosts Australia's participation in the International Polar Year, and knowledge about Antarctic Territorial waters. Infrastructure benefit comes from the French government paying for an outstanding French scientist to come to Australia 6 months/yr for 5 yrs. This grant acts as the base for larger projects that import EU and American funds.Read moreRead less
Improving Care Of The Dying With Chronic Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$130,000.00
Summary
Chronic heart failure is increasing in prevalence and is primarily a condition of ageing. Although chronic heart failure has worse outcomes than many cancers, patients are often denied the benefits of palliative care with its emphasis on symptom management, spirituality, emotional health and focus on family issues. This project seeks to assess the state of knowledge in Australia related to palliative care in chronic heart failure. Guidelines and care maps appropriate to Australian conditions wil ....Chronic heart failure is increasing in prevalence and is primarily a condition of ageing. Although chronic heart failure has worse outcomes than many cancers, patients are often denied the benefits of palliative care with its emphasis on symptom management, spirituality, emotional health and focus on family issues. This project seeks to assess the state of knowledge in Australia related to palliative care in chronic heart failure. Guidelines and care maps appropriate to Australian conditions will be developed and their usefulness assessed in improving care of patients and their families.Read moreRead less
Positron Nano-Dosimetry: Fundamental Measurements of Positron Interactions and their use in State-of-the-Art Modelling of Positron Transport. This proposal will provide unique experimental and theoretical information on how positrons, the electron antiparticles, interact with matter, in particular with biologically important molecules. This data will be used in a unique set of modelling approaches which will provide, for the first time, an insight into how positrons are transported through gases ....Positron Nano-Dosimetry: Fundamental Measurements of Positron Interactions and their use in State-of-the-Art Modelling of Positron Transport. This proposal will provide unique experimental and theoretical information on how positrons, the electron antiparticles, interact with matter, in particular with biologically important molecules. This data will be used in a unique set of modelling approaches which will provide, for the first time, an insight into how positrons are transported through gases, liquids and ultimately, soft matter. It will thus have important ramifications for diagnostic tools such as Positron Emission Tomography. The fundamental research will also shed light on one of the key 'mysteries' of life - why the biological building blocks of life possess a definite " handedness", or chirality.Read moreRead less
Three-dimensional magnetotelluric imaging of lithospheric-scale mineral systems from source to deposit. Geochemical studies indicate that world-class mineral deposits are partly sourced from fluids emerging from Earth's mantle and lower crust. Finding major mineral deposits in the future will therefore require knowledge of which parts of the crust and mantle yield the most prospective locations. However, there are few methods that can image deep Earth resources, and these can be very expensive ....Three-dimensional magnetotelluric imaging of lithospheric-scale mineral systems from source to deposit. Geochemical studies indicate that world-class mineral deposits are partly sourced from fluids emerging from Earth's mantle and lower crust. Finding major mineral deposits in the future will therefore require knowledge of which parts of the crust and mantle yield the most prospective locations. However, there are few methods that can image deep Earth resources, and these can be very expensive. We propose to develop the magnetotelluric method as a low-cost and rapid approach for delineating 3D information on deep mineral systems beneath existing major deposits, and adapting this to explore in greenfield locations.Read moreRead less
Predicting Renal, Ophthalmic And Heart Events In The Aboriginal Community: The PROPHECY Diabetes Multi-Omics Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$3,955,505.00
Summary
Diabetes is at epidemic levels in Indigenous Australians, impairing quality of life, and contributing to poor health. This is a result of rapid development of kidney, heart and eye complications. We have established a large long-term population study among Aboriginal communities within South Australia and will explore the burden, natural history and the social, psychological, environmental, clinical and genomic predictors of diabetes and its complications.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668155
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Pl ....Instrumentation for combined seismic and electromagnetic Earth sounding. The set of geophysical recorders will provide the means to enhance understanding of the structure of the Australian continent in 3-D. The interpretation of multiple images of Earth structure will help to link features in the crust and mantle beneath, and provide controls on the evolution and assembly of the present continent, with a major contribution to possible geotransects as recommended in the 2003 National Strategic Plan for the Geosciences. Combining seismic and electromagnetic methods will provide both geochemeical and geophysical constaints, e.g., on zones of alteration and shear with the potential for deep mineralisation. Read moreRead less
Targeting RCAN1 To Treat Type 2 Diabetes And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$814,468.00
Summary
Obesity and impaired insulin secretion are significant contributors to Type 2 diabetes. In this project we demonstrate that a protein called RCAN1 contributes to both fat mass and insulin secretion and that this contribution is exacerbated in obesity and in Type 2 diabetes. We will identify how RCAN1 controls these major metabolic pathways with outcomes including the development of new therapeutics for obesity and Type 2 diabetes.
Bitter Taste As A Mediator Of Food Intake And Postprandial Glycaemia In Health And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$735,430.00
Summary
The gut “tastes” contents passing through it in a similar manner to the tongue. Recent evidence suggests that bitter substances in the gut can reduce appetite and slow the emptying of meals from the stomach, by stimulating gastrointestinal hormone release. We propose studies to understand how this system functions in health and type 2 diabetes, and whether it can be targeted to provide new diabetes treatments