Assessing The Utility Of Circulating Cell-free MicroRNA As Biomarkers For Response In A Variety Of Non Hodgkin Lymphomas
Funder
National Health and Medical Research Council
Funding Amount
$92,159.00
Summary
Non Hodgkin Lymphomas are the most common blood cancer to affect adult Australians. The current strategies for diagnosis, treatment and monitoring of these patients are generic and not tailored to features of particular patientÍs lymphoma or treatment response. We aim to develop a new blood based marker for Lymphoma that can be used to diagnose and monitor NHL patients, to allow treatment to be adjusted according the patients current response to therapy, as indicated by the blood based marker. T
Effects Of A Novel Hotspot Mutation Of Brm In Non-Melanoma Skin Cancer Development
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Australia has the highest incidence of skin cancer in the world. SWI/SNF, a yeast nucleosome remodeling complex, is known destabilise interactions in DNA. It is made up of 8-10 proteins, including a novel tumour suppressor Brm. There is some evidence that Brm acts as a tumour suppressor in skin cancer, but relevance of a recently found mutation in Brm is yet to be characterised. This project aims to identify the effect of this mutation, on cellular sensitivity to UV radiation and examine transfo ....Australia has the highest incidence of skin cancer in the world. SWI/SNF, a yeast nucleosome remodeling complex, is known destabilise interactions in DNA. It is made up of 8-10 proteins, including a novel tumour suppressor Brm. There is some evidence that Brm acts as a tumour suppressor in skin cancer, but relevance of a recently found mutation in Brm is yet to be characterised. This project aims to identify the effect of this mutation, on cellular sensitivity to UV radiation and examine transformation to malignancy.Read moreRead less
The Use Of Real-World Evidence To Support Regulatory And Reimbursement Decisions
Funder
National Health and Medical Research Council
Funding Amount
$91,538.00
Summary
Traditionally, medicines are studied extensively in clinical trials before they are widely available. More recently, some medicines have been allowed to enter the market without complete data on their benefits and risks. This means that these issues can only be studied once a medicine is on the market and used in routine clinical practice; this is referred to as real-world evidence. This research evaluates if this evidence is sufficient to prove that a medicine is safe and that it works
Improving CPR Quality By Optimising The Language Used In CPR Instructions
Funder
National Health and Medical Research Council
Funding Amount
$76,365.00
Summary
A mixed methods project to determine if the quality of dispatcher assisted cardiopulmonary resuscitation (DA-CPR) can be improved by understanding and including the wording used by laypeople to describe CPR. This study will seek input from lay people through focus groups and test the effectiveness of the changes to DA-CPR instructions, with the objective to determine the impact of including these descriptions in DA-CPR instructions on the quality of CPR in a simulation study.
Joint Longitudinal And Time-to-event Models For Applications In Health Research
Funder
National Health and Medical Research Council
Funding Amount
$86,073.00
Summary
A recently developed statistical technique ("joint modelling") allows for both repeatedly measured biomarker data (for example, blood pressure measurements) and event time data (for example, time until death) to be analysed together. There are several potential benefits to using these models, but since the methods are relatively new their uptake in applied health research remains limited. This PhD will consist of several distinct but interrelated projects which explore the use of these models.
A Dietary Intervention For Sarcopenia In Cirrhosis
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Patients with chronic liver failure, or cirrhosis, suffer many complications. Sarcopenia, the loss of muscle and muscle weakness, is one of these. It is associated with reduced survival. Patients with cirrhosis have low levels of branched chain amino acids (BCAAs) which are used as building blocks for protein and energy in muscle. We aim to explore how oral supplements of BCAAs might improve muscle in this population. If this improves muscle mass, we also expect it may improve other outcomes.
Maximising The Population Impact Of Digital Self-management Programs To Improve Type 2 Diabetes Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$64,713.00
Summary
My PhD research will determine how user engagement with a digital diabetes program improves sustained diabetes outcomes and which program features contribute most to this improvement within disadvantaged people with diabetes. In addition to ensuring that such programs are equitable and optimise health gains of all Australians with T2DM, findings from my research will also help realise the potential of this technology to be used to address other chronic illness management.
Diabetes And Cardiovascular Risk Among Indigenous Women After Pregnancy Complicated By Hyperglycaemia.
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Indigenous Australian women are at high risk of having GDM which increases the risk of developing both GDM in future pregnancies and T2DM. We want to clarify these risks and whether there are differences between Indigenous and non-Indigenous women. Ideally, we can intervene to prevent this cycle of disease as diabetes in pregnancy has long term poor health outcomes for both mothers and their offspring.
Quality Of Life, Associated Psychological And Economic Family Impacts, And Trajectory Of Recovery In Aboriginal And Torres Strait Islander Paediatric Burns Patients.
Funder
National Health and Medical Research Council
Funding Amount
$86,117.00
Summary
Over a third of burns injuries in Australia are paediatric, with over representation of Aboriginal and Torres Strait Islander children. Burns are a major injury, having devastating long term consequences, connected to psychological distress, trauma, cost and disability. This research focusses on quality of life measures, economic impacts and psychological distress, investigating enabling and inhibitory factors to burns recovery in Aboriginal and Torres Strait Islander children and their family.
Determining The Natural History Of Localized High-risk Melanoma And Risk Factors For Melanoma Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$103,980.00
Summary
This PhD thesis aims to describe 2-year survival rates of patients with localised melanoma. We will investigate risk factors and patterns of melanoma spread in patients with high-risk localised lesions. Risk factors for developing ulcerated versus non-ulcerated melanomas will be explored. We aim to describe support service use in melanoma patients in rural, regional and urban areas in Queensland.