Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Science for Sustainable Management of Coral Reef Biodiversity: a multi-disciplinary approach to global-scale processes and patterns. Hughes will lead an international team to undertake a multi-disciplinary program of research that will quantify the processes underlying biodiversity patterns on coral reefs, focussing on ecological and evolutionary mechanisms of these complex systems at multiple scales in space and time. A novel modelling component will provide the mechanistic link between multi-s ....Science for Sustainable Management of Coral Reef Biodiversity: a multi-disciplinary approach to global-scale processes and patterns. Hughes will lead an international team to undertake a multi-disciplinary program of research that will quantify the processes underlying biodiversity patterns on coral reefs, focussing on ecological and evolutionary mechanisms of these complex systems at multiple scales in space and time. A novel modelling component will provide the mechanistic link between multi-scale processes and regional-scale patterns. This research will cement Australia's leading contribution to coral reef science, and will guide the management, sustainable use and conservation of coral reef biodiversity across international boundaries.Read moreRead less
Principles of Quantum Information Science. The use of quantum mechanical systems to carry and process information is enabling a revolution in information technology through innovations such as quantum computation and quantum teleportation. This project investigates the fundamental theory of quantum information science. The project aims to formulate general principles governing the power and behaviour of quantum information. These principles will, in turn, enable the development of powerful new ....Principles of Quantum Information Science. The use of quantum mechanical systems to carry and process information is enabling a revolution in information technology through innovations such as quantum computation and quantum teleportation. This project investigates the fundamental theory of quantum information science. The project aims to formulate general principles governing the power and behaviour of quantum information. These principles will, in turn, enable the development of powerful new applications of quantum information. Principal areas to be addressed include: general conditions for a physical system to be usable for quantum computation, the development of new algorithms for quantum computers, the development of new quantum communication protocols, and the theory of quantum entanglement.Read moreRead less
Assembly of neural circuits during development. This program aims to understand how nerve cells wire up accurately during development. Specifically, the program will determine how neuronal connections are established in the retina to produce a sensory structure essential for vision. The program will also generate innovative tools for watching in live animals, the making and breaking of connections during normal and abnormal development. Discoveries will not only significantly increase our knowle ....Assembly of neural circuits during development. This program aims to understand how nerve cells wire up accurately during development. Specifically, the program will determine how neuronal connections are established in the retina to produce a sensory structure essential for vision. The program will also generate innovative tools for watching in live animals, the making and breaking of connections during normal and abnormal development. Discoveries will not only significantly increase our knowledge base of how the nervous system develops or degenerates, but the results will provide crucial information for future studies based on genetic approaches, drug therapies and bioengineering technology to repair the injured nervous system.Read moreRead less
The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced gen ....The genomic programming of complex organisms. The project will have far-reaching consequences in medicine, agriculture, biotechnology, engineering, information science and associated industries. It will provide a platform for the rationalization of genetic epidemiology and genetic improvement programs, the development of a wide range of new diagnostics and therapies, the development of new core technologies and practical approaches in genetics and genetic diversity, a framework for advanced genetic engineering, the development of new principles and systems for information storage and transmission, and the design of artificial systems capable of self-referential assembly in other environments.Read moreRead less