Muir Torre Syndrome: The Role Of IHC And Genotyping In Sebaceous Neoplasia To Facilitate Prevention Strategies In Colorectal And Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,786.00
Summary
Sebaceous neoplasia (SN), may be an early warning sign for Lynch syndrome (LS), an inherited cancer predisposition caused by mutations in a group of genes. There are high lifetime risks of bowel and uterine cancer, for which there are effective risk management plans if the risk is known. Clinicians are challenged by the role of SN in identifying LS. At present, it is hard to differentiate. We aim to determine features to improve the diagnosis of LS carriers.
Australian Laureate Fellowships - Grant ID: FL180100040
Funder
Australian Research Council
Funding Amount
$3,208,274.00
Summary
Catalysing solutions to climate change in low-lying islands. This project aims to create new knowledge about successful adaptation to climate change on low-lying islands. There is a poor understanding of how communities in low-lying islands can adapt to climate change. This project seeks to provide evidence about adaptation practices to sustain island communities through a changing climate. Expected outcomes include developing a database of adaptation strategies, creating systems for monitoring ....Catalysing solutions to climate change in low-lying islands. This project aims to create new knowledge about successful adaptation to climate change on low-lying islands. There is a poor understanding of how communities in low-lying islands can adapt to climate change. This project seeks to provide evidence about adaptation practices to sustain island communities through a changing climate. Expected outcomes include developing a database of adaptation strategies, creating systems for monitoring change, and building capacity of early career researchers. This project is expected to enhance our understanding of adaptation and resilience to environmental change in Australia and low lying regions.Read moreRead less
Equitable local outcomes in adaptation to sea-level rise. The project clearly falls within the priority goal of responding to climate change and variability in being about responding to sea-level rise. It is of direct benefit to rural communities in Gippsland that are vulnerable to sea-level rise, and the project has been identified as a priority research need by the Gippsland Coastal Board, local governments in Gippsland, and the Victorian Government, all of whom are partners in this project. T ....Equitable local outcomes in adaptation to sea-level rise. The project clearly falls within the priority goal of responding to climate change and variability in being about responding to sea-level rise. It is of direct benefit to rural communities in Gippsland that are vulnerable to sea-level rise, and the project has been identified as a priority research need by the Gippsland Coastal Board, local governments in Gippsland, and the Victorian Government, all of whom are partners in this project. The guidelines produced will contribute to improved decision making about adaptation nationally and internationally, and the project's intellectual outcomes will be of interest and values to researchers working in Australia and abroad.Read moreRead less
Biomarker-driven Applications Of Immunotherapy In Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Immunotherapy is a new treatment strategy that works in many different lymphoma types but there is no successful method of predicting response or selecting patients. I aim to explore use of immunotherapy in 3 key lymphoma subtypes to identify new techniques for predicting which patients respond to treatment through prospective biomarker research using novel techniques. These aims will be achieved through a series of clinical trials of immunotherapy in lymphoma all with a biomarker research focus
The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of fac ....The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of factors associated with the inaccuracy and bias of greenhouse gas emissions reported by companies and the consequences of the inaccuracies for the share market's valuation of emission liabilities. These research findings will identify issues that need to be addressed by regulators to ensure that the greenhouse gas estimates reported by companies are reliable.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989986
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims ....Hybrid Fourier Transform Dispersive Raman Micro-Spectrometer. This facility will be used in a wide range of existing and new research projects in government priority areas such as the development of new materials, frontier technologies for building and transforming existing industries, better understanding of diversity and functioning in mycorrhizal and other fungi in forest soils and plant roots and developing new characterisation methods for forensic investigations. The proposed equipment aims to provide outstanding opportunities for the training of research students, expanding research in the fields of materials, minerals, geological, environmental and forensic science enabling to maintain Australia's lead and competitiveness in cutting edge research and technology. Read moreRead less
An Extensible agent-based framework for exploring climate change adaptation. The benefit of this project is the provision of an extensible leading edge technological platform for exploration of critical problems of Climate Change Adaptation (CCA). This will enable policy makers and social scientists to explore the complex interactions of different approaches to adaptation thus informing this critical area understanding. The research questions addressed will also provide more general benefits in ....An Extensible agent-based framework for exploring climate change adaptation. The benefit of this project is the provision of an extensible leading edge technological platform for exploration of critical problems of Climate Change Adaptation (CCA). This will enable policy makers and social scientists to explore the complex interactions of different approaches to adaptation thus informing this critical area understanding. The research questions addressed will also provide more general benefits in the area of agent based modelling and simulation, facilitating principled modelling of more complex entities within simulations. Building on top of a platform with an existing large user base facilitates contributions to the extensible platform, and the application area of CCA, by a wide range of people.Read moreRead less
The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and ....The Coupling of Plasticity, Microstructure and Phase Transformations in the Design of Novel Magnesium Alloys for the Automotive Industry. The desire to reduce the weight of automobiles due to legislative requirements on fuel emissions and to reduce overall fuel consumption is the driving force behind research into the development of new Mg-based alloys to replace the heavier steel and Al-alloy components in automobiles. Given the enormous worldwide transportation market and the environmental and legislative motivation for reducing fuel emissions, the development of new Mg-based alloys capable of meeting this demand from automotive manufacturers represents both a potentially large economic advantage to the country of development as well as helping to address the environmental concern about fuel emissions.Read moreRead less
Assimilation of trace atmospheric constituents for climate (ATACC): Linking chemical weather and climate. Changes in atmospheric ozone and carbon dioxide affect many aspects of surface climate from changes in ultraviolet radiation (ozone) to long-term changes in temperature (carbon dioxide). Better mapping of these gases will help us understand, predict and manage these changes. For ozone, it will clarify the link between ozone and surface weather. For carbon dioxide, improved knowledge of the ....Assimilation of trace atmospheric constituents for climate (ATACC): Linking chemical weather and climate. Changes in atmospheric ozone and carbon dioxide affect many aspects of surface climate from changes in ultraviolet radiation (ozone) to long-term changes in temperature (carbon dioxide). Better mapping of these gases will help us understand, predict and manage these changes. For ozone, it will clarify the link between ozone and surface weather. For carbon dioxide, improved knowledge of the impact of tropical deforestation, land clearing and changes in the southern ocean on atmospheric CO2 will support sustainable development in Australia and our region. The project hence addresses the priority goal 'Responding to climate change and variability` under the National Research Priority 'An Environmentally Sustainable Australia`.
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Rural adjustment or structural transformation? Discovering the destinations of exiting farm families. The findings of this research will assist local, State and Federal governments to intervene effectively in processes of regional and rural structural adjustment. It will generate economic benefits by recommending policies that facilitate growth and promote sustainable rural businesses while at the same time sheltering rural communities and individual households from adverse outcomes. It will con ....Rural adjustment or structural transformation? Discovering the destinations of exiting farm families. The findings of this research will assist local, State and Federal governments to intervene effectively in processes of regional and rural structural adjustment. It will generate economic benefits by recommending policies that facilitate growth and promote sustainable rural businesses while at the same time sheltering rural communities and individual households from adverse outcomes. It will contribute social benefits by identifying policies to improve the outcomes of rural adjustment for families and individuals. The new knowledge it provides will inform the politics of regional change and remove some of the uncertainties that currently impede the implementation of rural adjustment policies.Read moreRead less