The transcriptome, genome and metagenome of Acropora millepora: a model system for studying coral health and disease. Corals have an iconic significance for Australia, which has the best-preserved reef system in the world. The Great Barrier Reef is worth more than $6 billion per year to the Australian economy, and provides employment for 68000 people. The research will provide insights into the molecular bases of stress and disease in corals and the internal mechanisms by which corals attempt to ....The transcriptome, genome and metagenome of Acropora millepora: a model system for studying coral health and disease. Corals have an iconic significance for Australia, which has the best-preserved reef system in the world. The Great Barrier Reef is worth more than $6 billion per year to the Australian economy, and provides employment for 68000 people. The research will provide insights into the molecular bases of stress and disease in corals and the internal mechanisms by which corals attempt to combat them. The results will allow the design of strategies for better reef management, resulting in economic, environmental and social benefits for Australia.Read moreRead less
Ecological consequences of hydrodynamic disturbances. The Great Barrier Reef is synonymous with Australia to many people worldwide. Consequently, it is of paramount importance to our national tourism industry. As stewards of this unique ecosystem, we are responsible for ensuring its persistence under not only present, but also future climate scenarios. To do so requires the tools for predicting the ecological impacts of physical disturbance that this project will develop. Because of its global s ....Ecological consequences of hydrodynamic disturbances. The Great Barrier Reef is synonymous with Australia to many people worldwide. Consequently, it is of paramount importance to our national tourism industry. As stewards of this unique ecosystem, we are responsible for ensuring its persistence under not only present, but also future climate scenarios. To do so requires the tools for predicting the ecological impacts of physical disturbance that this project will develop. Because of its global significance, this work will continue to generate high-impact publications that will increase the international research profile of Australia. Finally, this project will generate collaborations with top researchers worldwide and will provide high quality training to postgraduate students.
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Muir Torre Syndrome: The Role Of IHC And Genotyping In Sebaceous Neoplasia To Facilitate Prevention Strategies In Colorectal And Endometrial Cancer
Funder
National Health and Medical Research Council
Funding Amount
$396,786.00
Summary
Sebaceous neoplasia (SN), may be an early warning sign for Lynch syndrome (LS), an inherited cancer predisposition caused by mutations in a group of genes. There are high lifetime risks of bowel and uterine cancer, for which there are effective risk management plans if the risk is known. Clinicians are challenged by the role of SN in identifying LS. At present, it is hard to differentiate. We aim to determine features to improve the diagnosis of LS carriers.
Global Lithospheric Architecture Mapping II. The continents have been rifted, or broken up, and collided, or re-assembled, along major zones of weakness many times throughout Earth's history. Boundaries between such continental domains focus large-scale movements of fluids that can produce giant ore deposits. This study will provide new perspectives on the localisation of world-class economic deposits, the Earth resources on which society depends. Innovations in imaging the deep Earth beneath co ....Global Lithospheric Architecture Mapping II. The continents have been rifted, or broken up, and collided, or re-assembled, along major zones of weakness many times throughout Earth's history. Boundaries between such continental domains focus large-scale movements of fluids that can produce giant ore deposits. This study will provide new perspectives on the localisation of world-class economic deposits, the Earth resources on which society depends. Innovations in imaging the deep Earth beneath continents, and in numerical modelling, will maintain our high international profile in research relevant to National Priority 1.6 (Developing Deep Earth Resources). Unique 3D geological maps of regions down to 250km will make the composition of deep Earth regions newly accessible to geoscientists and all potential endusers.Read moreRead less
Deep Coal Mining. The occurrence of progressively larger gas outbursts, coal bumps, and the potential for the catastrophic collapse of coal pillars is of increasing importance as mining drives deeper in seams rich in methane and other hydrocarbons. This study will address this issue by examining the roles of stress level, strain-rate, gas desorption rate, and drained and undrained gas and liquid pressures in the dynamic failure of coal, while simultaneously evaluating the promise and fidelity of ....Deep Coal Mining. The occurrence of progressively larger gas outbursts, coal bumps, and the potential for the catastrophic collapse of coal pillars is of increasing importance as mining drives deeper in seams rich in methane and other hydrocarbons. This study will address this issue by examining the roles of stress level, strain-rate, gas desorption rate, and drained and undrained gas and liquid pressures in the dynamic failure of coal, while simultaneously evaluating the promise and fidelity of a variety of hazard indices and precursive signals.Read moreRead less
Equitable local outcomes in adaptation to sea-level rise. The project clearly falls within the priority goal of responding to climate change and variability in being about responding to sea-level rise. It is of direct benefit to rural communities in Gippsland that are vulnerable to sea-level rise, and the project has been identified as a priority research need by the Gippsland Coastal Board, local governments in Gippsland, and the Victorian Government, all of whom are partners in this project. T ....Equitable local outcomes in adaptation to sea-level rise. The project clearly falls within the priority goal of responding to climate change and variability in being about responding to sea-level rise. It is of direct benefit to rural communities in Gippsland that are vulnerable to sea-level rise, and the project has been identified as a priority research need by the Gippsland Coastal Board, local governments in Gippsland, and the Victorian Government, all of whom are partners in this project. The guidelines produced will contribute to improved decision making about adaptation nationally and internationally, and the project's intellectual outcomes will be of interest and values to researchers working in Australia and abroad.Read moreRead less
Biomarker-driven Applications Of Immunotherapy In Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Immunotherapy is a new treatment strategy that works in many different lymphoma types but there is no successful method of predicting response or selecting patients. I aim to explore use of immunotherapy in 3 key lymphoma subtypes to identify new techniques for predicting which patients respond to treatment through prospective biomarker research using novel techniques. These aims will be achieved through a series of clinical trials of immunotherapy in lymphoma all with a biomarker research focus
The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of fac ....The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of factors associated with the inaccuracy and bias of greenhouse gas emissions reported by companies and the consequences of the inaccuracies for the share market's valuation of emission liabilities. These research findings will identify issues that need to be addressed by regulators to ensure that the greenhouse gas estimates reported by companies are reliable.Read moreRead less
Rapid approximate imaging of electromagnetic data acquired using multichannel distributed acquisition systems. This project will investigate techniques for rapid, multidimensiuonal imaging of electromagnetic data acquired using modern multichannel distributed acquisition systems. This research will provide high-resolution images of buried ore deposits at greater depths than is possible using current instruments and processing techniques.
Eucalypt growth in past and future environments - a novel approach to understanding the impacts of atmospheric CO2 and climate. The impact of climate change and rising atmospheric CO2 on Australia's plantation and native forests is a major concern for government and land managers. These forests are important for environmental, aesthetic, and economic purposes, including carbon sequestration and trading. Forests use large amounts of water, reducing stream flow and water supplies for rural and u ....Eucalypt growth in past and future environments - a novel approach to understanding the impacts of atmospheric CO2 and climate. The impact of climate change and rising atmospheric CO2 on Australia's plantation and native forests is a major concern for government and land managers. These forests are important for environmental, aesthetic, and economic purposes, including carbon sequestration and trading. Forests use large amounts of water, reducing stream flow and water supplies for rural and urban communities. Knowledge generated from the proposed project will provide insight into mechanisms driving productivity and water use of forests in current and future environments. The knowledge will be used by land managers and government to develop strategies to cope with future impacts of climate change.Read moreRead less