An abnormal blood pressure (BP) response to a clinical exercise stress test is a signal for increased cardiovascular disease risk. However, current clinical guidelines do not provide evidence based information surrounding values that may constitute this increased risk. The EXERcise stress Test collaboratION (EXERTION) aims to fill this knowledge gap via establishment of a large, national database of exercise stress test results, linked to acute and chronic cardiovascular disease outcomes.
NOVEL NON-INVASIVE METHODS FOR THE EARLY DETECTION OF PULMONARY VASCULAR DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$320,463.00
Summary
Pulmonary arterial hypertension (PAH) is a severe, progressive disorder. Current non-invasive diagnostic modalities are insensitive for detecting early disease, thus preventing early intervention with therapy. We aim to develop novel and reproducible ways to assess the pulmonary circulation, which will ultimately allow for the early diagnosis of PAH and in turn facilitate early initiation of treatment and improved patient outcomes.
Structural And Functional Correlates In Adult Congenital Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$89,699.00
Summary
Survival in congenital heart disease patients has improved. Despite long-term sequelae, evidence is scarce. We aim to correlate structural cardiac features on MRI in adults with exercise capacity to determine predictors of poor outcome. Non-compaction cardiomyopathy ("spongy" heart) is a rare, unclassified form of heart failure. The incidence is much higher in patients with congenital heart disease. We aim to examine the causes, mechanical consequences and its effects on cardiac electrical condu ....Survival in congenital heart disease patients has improved. Despite long-term sequelae, evidence is scarce. We aim to correlate structural cardiac features on MRI in adults with exercise capacity to determine predictors of poor outcome. Non-compaction cardiomyopathy ("spongy" heart) is a rare, unclassified form of heart failure. The incidence is much higher in patients with congenital heart disease. We aim to examine the causes, mechanical consequences and its effects on cardiac electrical conduction to understand this undefined entity.Read moreRead less
Central Blood Pressure: Physiology And Clinical Application
Funder
National Health and Medical Research Council
Funding Amount
$459,270.00
Summary
Current methods used by doctors to measure blood pressure (BP) have many limitations that could result in incorrect diagnosis and inappropriate treatment of high BP (hypertension). This research program will determine the clinical usefulness of new methods to diagnose and treat people with high BP. The underlying mechanisms contributing to high BP will also be examined. The findings will lead to improved ways to identify and more effectively manage people with high BP.