Functionalised MMP Inhibitors as Radiodiagnostic, Radiotherapeutic, and Radiation-Sensitising Agents for Metastatic Cancer. Identifying and treating malignant cancers is one of the major challenges facing the scientific and medical communities. In order to minimise side effects that accompany most treatments of cancer it is necessary to find ways of targeting the therapy to tumours and away from healthy organs. A difference between tumours and healthy tissues is the amount of the proteins (calle ....Functionalised MMP Inhibitors as Radiodiagnostic, Radiotherapeutic, and Radiation-Sensitising Agents for Metastatic Cancer. Identifying and treating malignant cancers is one of the major challenges facing the scientific and medical communities. In order to minimise side effects that accompany most treatments of cancer it is necessary to find ways of targeting the therapy to tumours and away from healthy organs. A difference between tumours and healthy tissues is the amount of the proteins (called MMPs) that tumours use to break out of their surroundings, to break into and out of the blood system, and to establish new colonies of cancer cells or metastases. This difference also distinguishes the most aggressive cancers. The purpose of this project is to develop means of identifying and targeting cancers using molecules that bind to these MMP proteins.Read moreRead less
Superfluid helium nanodroplet spectroscopy. Molecules trapped in a helium nanodroplet find themselves in an ultracold liquid environment from which they cannot escape. As such, the molecules are forced to interact and this is studied at a resolution that is unrivaled in condensed phase spectroscopy. This technique will be used to create new materials and study the dynamics behind a large range of chemical processes. The results are expected to lead to a greater understanding of condensed phase c ....Superfluid helium nanodroplet spectroscopy. Molecules trapped in a helium nanodroplet find themselves in an ultracold liquid environment from which they cannot escape. As such, the molecules are forced to interact and this is studied at a resolution that is unrivaled in condensed phase spectroscopy. This technique will be used to create new materials and study the dynamics behind a large range of chemical processes. The results are expected to lead to a greater understanding of condensed phase chemistry and chemical reactions in general.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882357
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
A Computational Facility for Multi-scale Modelling in Bio and Nanotechnology. Bio- and nanotechnology have the potential to transform Australian industry and research, and to bring significant benefits for consumers. The scope will include materials for energy storage, medical diagnostics and cellular imaging, bioengineering, drug and gene delivery, improved foods by molecular design, novel materials for electronics, improved techniques for particle processing, and molecular sieves for filtering ....A Computational Facility for Multi-scale Modelling in Bio and Nanotechnology. Bio- and nanotechnology have the potential to transform Australian industry and research, and to bring significant benefits for consumers. The scope will include materials for energy storage, medical diagnostics and cellular imaging, bioengineering, drug and gene delivery, improved foods by molecular design, novel materials for electronics, improved techniques for particle processing, and molecular sieves for filtering/purifying water and gases. The dedicated computing facility will enable a fast interactive cycle between simulation and experiment in these areas, accelerating the pace of research and applications.Read moreRead less
Fine Structured Optical Fibre Fabrication - Soot, Rheology and Nanostructure in Modified Chemical Vapour Deposition. For 30 years photonics and telecommunications have relied heavily on optical fibres made by Modified Chemical Vapour Deposition (MCVD), a complex, highly dynamic process with many interacting variables, which is still more art than science. The results are good enough for most purposes but the next generation of photonics demands fibres with intricate, precisely defined internal s ....Fine Structured Optical Fibre Fabrication - Soot, Rheology and Nanostructure in Modified Chemical Vapour Deposition. For 30 years photonics and telecommunications have relied heavily on optical fibres made by Modified Chemical Vapour Deposition (MCVD), a complex, highly dynamic process with many interacting variables, which is still more art than science. The results are good enough for most purposes but the next generation of photonics demands fibres with intricate, precisely defined internal structures. A multi-disciplinary team will elucidate and quantify the exact nature of the fundamental science underlying MCVD - of silicate soot formation, deposition and heat treatment - and translate this into reproducibly fabricated fine structured fibres with high optical and mechanical performance.Read moreRead less