Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100036
Funder
Australian Research Council
Funding Amount
$4,999,600.00
Summary
ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical ....ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical production, more resilient spacecraft and robust regulatory frameworks. Industries and communities will benefit from a future workforce prepared for safe adoption, development and delivery of emerging techniques and advanced radiation technologies, enhancing Australia’s prosperity and security.Read moreRead less
Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to ....Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to improve radiotherapy treatments in patients with small lesions with sizes of up to a few centimetres. This will lead to an improved outcome for some cancer patients.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882531
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested i ....Quantum Limited Single Atom Detectors. The technology that has shaped our society, solid state diodes, transistors and computer chips is based on our ability to manipulate the average quantum properties of materials such as semiconductors. This physics has been well understood for decades. Many technologies that will shape our societies in this century will be based on our ability to manipulate quantum systems precisely, an area that is the focus of quantum atom optics. The detectors requested in this proposal will ensure that Australia remains competitive in the technologies that will emerge from the new field of quantum atom optics.Read moreRead less
Ultracold atomic Fermi gases in the strongly interacting regime: A new frontier of quantum many-body physics. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics have been awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with ....Ultracold atomic Fermi gases in the strongly interacting regime: A new frontier of quantum many-body physics. Ultra-cold atoms are one of the most rapidly developing areas in twenty-first century physics. The scientific importance of studying strongly interacting Fermi gases is indicated by the fact that five Nobel prizes in physics have been awarded in fields relevant to ultra-cold atoms in the last decade. Australia is now developing a reputation for world-class research in this new area, with new cold-fermion experiments now underway in Melbourne. This project will build national and international cooperation in this field, provide world-class research training opportunities and advance Australia's leadership position. As well as improving scientific understanding, it has the potential to lead to new energy-saving technologies in future.Read moreRead less
Australian Centre for Quantum-Atom Optics. The Centre will combine pre-eminent Australian theoretical and experimental research groups in quantum and atom optics to create a powerful network to advance the rapidly developing field of Quantum-Atom Optics. We will exploit the quantum nature of multiple particle quantum states of atoms and photons including entangled light and Bose-Einstein condensates. The Centre will focus on fundamental research, but our long term goal is to underpin and develo ....Australian Centre for Quantum-Atom Optics. The Centre will combine pre-eminent Australian theoretical and experimental research groups in quantum and atom optics to create a powerful network to advance the rapidly developing field of Quantum-Atom Optics. We will exploit the quantum nature of multiple particle quantum states of atoms and photons including entangled light and Bose-Einstein condensates. The Centre will focus on fundamental research, but our long term goal is to underpin and develop the next generation quantum technology. We aim to build a quantum toolbox to enable applications such as the transfer and storage of information for photonics, and precision quantum control of atoms for enhanced atom interferometry.Read moreRead less
Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercial ....Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercially viable product - the neutral helium beam microscope. The possibilities of using the microscope system as a nanofabrication device would also give researchers in Australia the ability to fabricate structures that could not be manufactured anywhere else in the world.Read moreRead less
Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotec ....Dynamics and correlations of many-body systems. The proposed program will greatly enhance Australian science through linking innovative
theoretical techniques with the successful ongoing Australian experimental program in atom
lasers, atom chip interferometry and ultra-cold fermions. Pioneering theoretical methods in
quantum phase-space are internationally recognized, and will be extended into new areas relevant
to Australia. These have fundamental significance to fields ranging from nanotechnology to
astrophysics, as well as providing a route to improved atomic clocks and other instruments.
Combining these theoretical and computational methods from the physical sciences with biology
and genetics will provide future cross-disciplinary benefits to Australian biomedical science.Read moreRead less
Cosmological vacuum stability as a window on fundamental physics. Vacuum is not just the absence of matter: it is the lowest-energy state of our Universe. This project aims to investigate the existence of new particles via their impacts upon the vacuum of the Universe. It expects to develop methods required to extract information on the existence of new particles from the vacuum, using transitions between different vacua, resulting gravitational waves, and results from a broad range of other co ....Cosmological vacuum stability as a window on fundamental physics. Vacuum is not just the absence of matter: it is the lowest-energy state of our Universe. This project aims to investigate the existence of new particles via their impacts upon the vacuum of the Universe. It expects to develop methods required to extract information on the existence of new particles from the vacuum, using transitions between different vacua, resulting gravitational waves, and results from a broad range of other complementary experiments. Expected outcomes include comprehensive tests of four of the most compelling theoretical frameworks for new particles. Significant expected benefits include advanced training for Australian students in numerical methods, software development, statistical analysis and research computing.Read moreRead less
Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics ....Atomic scale imaging with high coherence electrons and ions. This project aims to combine a cold atom electron-ion source with a commercial microscope column for atomic-scale imaging in biosciences and materials science. Nanoscale imaging with electron and ion microscopy are tools for investigating the world at the atomic scale, underpinning development in modern technologies from semiconductor devices to medical treatments. This project will use ideas from laser cooling of atoms and atom optics to achieve new imaging modalities for time-lapse imaging of fundamental processes at the nano-scale. It will allow increasingly small scale resolution of fundamental processes at the nano-scale.Read moreRead less