Cancer Risks From Low-dose Ionising Radiation Following Diagnostic Medical Procedures
Funder
National Health and Medical Research Council
Funding Amount
$750,579.00
Summary
Our study investigates cancer risk following exposure to low doses of ionising radiation from medical procedures. Our first major paper linked over 800,000 CT exposures to cancer outcomes in a cohort of almost 11 million young Australians, and found that CT exposure predicted an increased incidence of leukaemia and most solid cancers. In our ongoing work we will incorporate nuclear medicine and other diagnostic x-rays, and estimate radiation dose for individual procedures and to specific organs.
New Copper and Rhenium Radiopharmaceuticals. The aims of this project are to provide new metal-based radiopharmaceuticals for the treatment of cancer, and the imaging of cancer and other conditions through the design and engineering of new coordination complexes of rhenium and copper. Various strategies will be used to selectively and specifically target these metal complexes to the desired areas in vivo for non-invasive imaging and therapeutic applications. The most promising candidates will be ....New Copper and Rhenium Radiopharmaceuticals. The aims of this project are to provide new metal-based radiopharmaceuticals for the treatment of cancer, and the imaging of cancer and other conditions through the design and engineering of new coordination complexes of rhenium and copper. Various strategies will be used to selectively and specifically target these metal complexes to the desired areas in vivo for non-invasive imaging and therapeutic applications. The most promising candidates will be tested in the appropriate cells.Read moreRead less
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Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to ....Characterisation and improvement of radiation beams used for radiotherapy of small lesions. This project aims to characterise the radiation dose from a medical linear accelerator after the beam has been shaped by a mini-multileaf collimator. The characterisation will be achieved through a combination of computer simulations and experimental investigation of the beam using the technique of three-dimensional gel dosimetry. When the dosage characteristics are known, techniques will be developed to improve radiotherapy treatments in patients with small lesions with sizes of up to a few centimetres. This will lead to an improved outcome for some cancer patients.Read moreRead less
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The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascin ....The Origin of Mass at the Large Hadron Collider. The Large Hadron Collider is an enormous worldwide effort to understand the building blocks of the Universe. This project will help strengthen world-class research capacity in one of the most exciting frontiers of basic research. It will excite more high-achieving students to pursue careers in science increasing the number of talented graduates in Australia. In addition the big fundamental questions addressed in this research are of great fascination to the general public and will help to further advance the public education of science.Read moreRead less
Origin of the Mass. A hundred metres below ground, under the French-Swiss border, scientists are preparing to travel back in time to study matter as it was in the first fractions of a second after the beginning of the Universe. They are building the world's largest scientific instrument to help reveal how this primordial matter developed into the building blocks that form the great diversity of today. Australian physicists are preparing to extract the few fundamental particles that will explain ....Origin of the Mass. A hundred metres below ground, under the French-Swiss border, scientists are preparing to travel back in time to study matter as it was in the first fractions of a second after the beginning of the Universe. They are building the world's largest scientific instrument to help reveal how this primordial matter developed into the building blocks that form the great diversity of today. Australian physicists are preparing to extract the few fundamental particles that will explain the origin of the mass from the debris of billions of proton collisions. While solving the major issue confronting particle physics today, we will train students who will subsequently apply their skills in fields as diverse as science, medicine, industry and finance.Read moreRead less
Predictions of nucleon-nucleus cross sections for all energies to 300 MeV based upon microscopic theories of N-A scattering. Cross sections from nucleon-nucleus scattering and reactions are central quantities of import in diverse fields of study. They are most important in evaluations for nucleon radiation therapy, in material science for radiation safety as well as damage to electronics, with use of accelerator technology for waste management as well as possible power generation. They are im ....Predictions of nucleon-nucleus cross sections for all energies to 300 MeV based upon microscopic theories of N-A scattering. Cross sections from nucleon-nucleus scattering and reactions are central quantities of import in diverse fields of study. They are most important in evaluations for nucleon radiation therapy, in material science for radiation safety as well as damage to electronics, with use of accelerator technology for waste management as well as possible power generation. They are important in fundamental physics problems as in nuclear astrophysics and in studies of radioactive nuclear ions. A theoretical framework is required to make reliable predictions of nucleon-nucleus scattering. This project seeks to establish predictive methods of analysis for all nucleon energies to 300 MeV. Read moreRead less