The Role Of Capsid Protein Nucleolar Localisation In Chikungunya Virus: Implications For Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$520,520.00
Summary
Chikungunya virus (CHIKV) is a globally widespread mosquito-borne alphavirus capable of causing considerable human morbidity and mortality. With no CHIKV vaccine or antiviral available this proposal aims to develop a live attenuated CHIKV vaccine, rationally designed by investigating the host cell nucleolar trafficking of CHIKV capsid protein. This vaccine has the potential to provide cross-protection against additional arthritogenic alphaviruses endemic to Australia such as Ross River virus.
Industrial Transformation Training Centres - Grant ID: IC230100036
Funder
Australian Research Council
Funding Amount
$4,999,600.00
Summary
ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical ....ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical production, more resilient spacecraft and robust regulatory frameworks. Industries and communities will benefit from a future workforce prepared for safe adoption, development and delivery of emerging techniques and advanced radiation technologies, enhancing Australia’s prosperity and security.Read moreRead less
ARC Centre of Excellence for Dark Matter Particle Physics. The Centre of Excellence for Dark Matter Particle Physics will deliver breakthroughs in our understanding of the Universe through the pursuit of the discovery of dark matter particles which comprise 80% of the mass of the universe. It assembles for the first time a strong and diverse team of physicists from particle, nuclear, and quantum physics as well as particle astrophysics. It will deliver high-profile experiments using new cutting- ....ARC Centre of Excellence for Dark Matter Particle Physics. The Centre of Excellence for Dark Matter Particle Physics will deliver breakthroughs in our understanding of the Universe through the pursuit of the discovery of dark matter particles which comprise 80% of the mass of the universe. It assembles for the first time a strong and diverse team of physicists from particle, nuclear, and quantum physics as well as particle astrophysics. It will deliver high-profile experiments using new cutting-edge technologies. The Centre will exploit the unique geographical location of the first underground physics lab in the Southern Hemisphere. The ultra-sensitive detectors and ultra-low radiation techniques will translate into a broad range of industrial applications and train a new generation of scientists.Read moreRead less
ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies ....ARC Centre of Excellence - Centre for Antimatter-Matter Studies. While our world is made of matter, all particles have anti-particles and the most abundant is the positron, the electron's antiparticle. It is the "workshop" for most anti-matter studies, particularly for the characterization of materials, including gases, polymers, insulators, thin films and surfaces, as well as the development of new and novel, nano-structured materials. The ARC Centre of Excellence in Antimatter-Matter Studies (CAMS) will bring together key Australian and international scientists to work in this emerging scientific field of antimatter-matter interactions. It will forge a unique and effective scientific team for state-of-the-art studies of the nano-world that underlies many everyday processes and new technologies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Exploring the gene regulation networks governing mitochondrial biogenesis in Arabidopsis. Mitochondria, subcellular organelles that perform many functions indispensable to plant growth and productivity, are dynamic compartments whose protein complement changes dramatically during plant development and under stress. Yet, the cellular processes that regulate the production of these organelles are virtually unknown. By combining conventional approaches with an extremely powerful holistic method for ....Exploring the gene regulation networks governing mitochondrial biogenesis in Arabidopsis. Mitochondria, subcellular organelles that perform many functions indispensable to plant growth and productivity, are dynamic compartments whose protein complement changes dramatically during plant development and under stress. Yet, the cellular processes that regulate the production of these organelles are virtually unknown. By combining conventional approaches with an extremely powerful holistic method for simultaneously examining the expression patterns of every gene in the model plant Arabidopsis, this project will identify proteins that regulate mitochondrial biosynthesis and uncover the gene networks that these proteins control. The project outcomes will provide new opportunities for the rational manipulation of plant growth and productivity.Read moreRead less
Genome Approaches to Investigate Metabolic Coordination in Plant Cells. Metabolism of C and N in legume nodules requires interaction between the symbiotic bacteria and plant organelles, particularly metabolism in plastids and mitochondria. Fixed N is assimilated through the de novo synthesis of purines in both plastids and mitochondria. However, each of the nine pathway enzymes is encoded by a single gene, indicating each protein is targeted to both organelles. Purine metabolism will provide ....Genome Approaches to Investigate Metabolic Coordination in Plant Cells. Metabolism of C and N in legume nodules requires interaction between the symbiotic bacteria and plant organelles, particularly metabolism in plastids and mitochondria. Fixed N is assimilated through the de novo synthesis of purines in both plastids and mitochondria. However, each of the nine pathway enzymes is encoded by a single gene, indicating each protein is targeted to both organelles. Purine metabolism will provide a model to assess the more general occurrence of dual-targeted proteins in plants. The aim is to identify and eventually exploit the signalling mechanism(s) that mediate communication between plastids and mitochondria.Read moreRead less