Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453521
Funder
Australian Research Council
Funding Amount
$508,374.00
Summary
National Heavy Ion Accelerator. The principal objectives are to develop a facility to provide energetic heavy ions for basic science, applications and research training. This will be accomplished through an enhancement of a superconducting linear accelerator using innovative technology, and extension of the available beam species through improvements to a large electrostatic tandem accelerator. The facility provides research resources for a broad range of national and international users.
Industrial Transformation Training Centres - Grant ID: IC230100036
Funder
Australian Research Council
Funding Amount
$4,999,600.00
Summary
ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical ....ARC Training Centre for Radiation Innovation. This Centre aims to train the next generation of transdisciplinary leaders to enable, grow and transform industries that utilise or are impacted by radiation. Rapid growth in the natural resources, health, space and national security sectors urgently requires a highly capable workforce with scientific and regulatory knowledge to develop new technologies and social licence needs to maximise benefits. Outcomes include new methods of radiopharmaceutical production, more resilient spacecraft and robust regulatory frameworks. Industries and communities will benefit from a future workforce prepared for safe adoption, development and delivery of emerging techniques and advanced radiation technologies, enhancing Australia’s prosperity and security.Read moreRead less
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.
ARC Centre of Excellence for Dark Matter Particle Physics. The Centre of Excellence for Dark Matter Particle Physics will deliver breakthroughs in our understanding of the Universe through the pursuit of the discovery of dark matter particles which comprise 80% of the mass of the universe. It assembles for the first time a strong and diverse team of physicists from particle, nuclear, and quantum physics as well as particle astrophysics. It will deliver high-profile experiments using new cutting- ....ARC Centre of Excellence for Dark Matter Particle Physics. The Centre of Excellence for Dark Matter Particle Physics will deliver breakthroughs in our understanding of the Universe through the pursuit of the discovery of dark matter particles which comprise 80% of the mass of the universe. It assembles for the first time a strong and diverse team of physicists from particle, nuclear, and quantum physics as well as particle astrophysics. It will deliver high-profile experiments using new cutting-edge technologies. The Centre will exploit the unique geographical location of the first underground physics lab in the Southern Hemisphere. The ultra-sensitive detectors and ultra-low radiation techniques will translate into a broad range of industrial applications and train a new generation of scientists.Read moreRead less
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring tha ....Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring that the evidence generated has contemporary policy relevance. The project expects to identify clear and actionable policy pathways to reduce child inequities in Australia, which can benefit decision makers by helping them to direct limited public funds towards intervention opportunities that will have the greatest impact.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less