Centre For Research Excellence In Reducing Healthcare Associated Infection
Funder
National Health and Medical Research Council
Funding Amount
$2,495,795.00
Summary
Each year in Australia 180,000 patients suffer a healthcare associated infection. Risk can be reduced with relatively simple technology but substantial costs arise with system wide adoption and monitoring. The economic paradigm is that funds can be invested for infection reduction to save costs and lives. The CRE will reveal the cost-effectiveness of infection control programmes and show health services decision-makers how to improve patient outcomes, save resources and save lives.
"Smart Food" - The fulcrum in the energy balance equation. The overall aim of the project is to establish how nutrients best promote an increase in energy expenditure and therefore weight loss. The experiments will be performed in rats using sophisticated technologies to introduce specific combinations of fats, carbohydrates or proteins directly into the stomach and then measure energy expenditure in a specialised type of energy burning rather than energy storing fat called brown adipose tissue. ...."Smart Food" - The fulcrum in the energy balance equation. The overall aim of the project is to establish how nutrients best promote an increase in energy expenditure and therefore weight loss. The experiments will be performed in rats using sophisticated technologies to introduce specific combinations of fats, carbohydrates or proteins directly into the stomach and then measure energy expenditure in a specialised type of energy burning rather than energy storing fat called brown adipose tissue. These experiments will uncover the mechanisms that relate nutrients in the stomach and activation of brown adipose tissue. They will provide a framework on which this project can build a knowledge of smart diets that will allow the effective control of body weight through modulation of energy expenditure. Read moreRead less
Evaluation of peanuts as a source of bioactive nutrients for enhancement of endothelial function and cognitive performance. Functional foods represent one of the fastest growing food markets in the world, particularly foods which can offset adverse health conditions. The Partner Organisation, Peanut Company of Australia (PCA), is committed to developing peanut varieties, such as the high oleic peanut, that are nutritionally superior to the traditional varieties. By investing in research PCA aims ....Evaluation of peanuts as a source of bioactive nutrients for enhancement of endothelial function and cognitive performance. Functional foods represent one of the fastest growing food markets in the world, particularly foods which can offset adverse health conditions. The Partner Organisation, Peanut Company of Australia (PCA), is committed to developing peanut varieties, such as the high oleic peanut, that are nutritionally superior to the traditional varieties. By investing in research PCA aims to substantiate the nutritional benefits of these products and position itself in functional foods. Scientific evaluation of the health benefits that can be derived from consuming foods will enhance the national food industry through the growth of domestic and international licensing and export markets, and provide new employment opportunities in both rural and manufacturing sectors.Read moreRead less
Adaptive and Integrated Resource Allocation. By leveraging progress in communication technologies, adaptive and integrated optimization systems will open innovative application areas critical to Australia, yet outside the scope of existing optimization technology. For instance, they will dispatch and reallocate ambulances in real time, help contain pandemics, allocate resources dynamically to extinguish bushfires, and assist in failure recovery of energy infrastrutures. These systems will also s ....Adaptive and Integrated Resource Allocation. By leveraging progress in communication technologies, adaptive and integrated optimization systems will open innovative application areas critical to Australia, yet outside the scope of existing optimization technology. For instance, they will dispatch and reallocate ambulances in real time, help contain pandemics, allocate resources dynamically to extinguish bushfires, and assist in failure recovery of energy infrastrutures. These systems will also solve existing logistics and manufacturing applications better, making these industries more effective and reactive. The project also aims at establishing a center of excellence in optimization in Melbourne with an international reputation in research, teaching, and industrial collaboration.Read moreRead less
Adequate nutrition is necessary for recovery from illness. 30-40% of hospitalised patients may be malnourished. The critically ill are at higher risk because of increased energy requirements yet often receive less than 50% of required nutritional intake. Adequate nutrition therapy is associated with improved patient outcomes, such as reduced mortality and reduced infectious complications. Robust strategies to implement of evidence-based recommendations for nutrition therapy are required.
The Effect Of Selected Nutraceuticals On Brain Blood Vessels And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$445,206.00
Summary
The human brain receives 1000L of blood per day, distributed through minute vessels called capillaries. The integrity and function of brain capillaries is compromised with aging and this may contribute to memory disturbances. Our laboratory has identified several naturally occurring compounds that prevent age-associated defects of brain capillaries. The primary aim of this project is to explore if these agents are beneficial for restoring brain capillary function and memory.
Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide t ....Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100635
Funder
Australian Research Council
Funding Amount
$448,801.00
Summary
Understanding the development of lifestyle behaviours in early childhood. This project adopts novel statistical modelling and machine learning approaches to understand the development of lifestyle behaviours in early childhood. Despite the pivotal role of lifestyle behaviours in influencing health and quality of life, little research exists on lifestyle behaviours in early childhood. This project will establish a comprehensive understanding of lifestyle behaviours in early childhood by identifyi ....Understanding the development of lifestyle behaviours in early childhood. This project adopts novel statistical modelling and machine learning approaches to understand the development of lifestyle behaviours in early childhood. Despite the pivotal role of lifestyle behaviours in influencing health and quality of life, little research exists on lifestyle behaviours in early childhood. This project will establish a comprehensive understanding of lifestyle behaviours in early childhood by identifying key developmental time points, mechanisms of behavioural change, and children at risk of developing poor lifestyle behaviours. The project will inform strategies and policies to optimise lifestyle behaviours from the start of life and showcase the capabilities of novel methods in advancing behavioural epidemiology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101025
Funder
Australian Research Council
Funding Amount
$456,106.00
Summary
Food for thought: identifying dietary influences on decision making. Cues that signal food are abundant in the surrounding environment, yet their ability to stimulate food consumption remains poorly understood. This project seeks to identify how food cues influence decision-making processes in the presence of food cues. It will also test how dietary habits alter responding to food cues, and explore the underlying neural mechanisms of these effects. Sophisticated behavioural neuroscience techniqu ....Food for thought: identifying dietary influences on decision making. Cues that signal food are abundant in the surrounding environment, yet their ability to stimulate food consumption remains poorly understood. This project seeks to identify how food cues influence decision-making processes in the presence of food cues. It will also test how dietary habits alter responding to food cues, and explore the underlying neural mechanisms of these effects. Sophisticated behavioural neuroscience techniques will be employed in a validated rodent model of the modern diet. Expected outcomes include new interdisciplinary knowledge identifying how nutritional choices influence cognition and the brain. The project should inform how the modern environment shapes dietary habits.Read moreRead less
Impact and Effectiveness of Personal Ventilation in Open Plan Offices: a study of the Task Air system. Centralised air-conditioning systems are the standard for commercial office buildings in Australia. These systems are energy intensive, typically accounting for around 50% of building energy use. However, lack of occupant control over set temperatures or air movement tends to reduce thermal comfort, which can adversely affect worker productivity. The benefit of this project is that it will qu ....Impact and Effectiveness of Personal Ventilation in Open Plan Offices: a study of the Task Air system. Centralised air-conditioning systems are the standard for commercial office buildings in Australia. These systems are energy intensive, typically accounting for around 50% of building energy use. However, lack of occupant control over set temperatures or air movement tends to reduce thermal comfort, which can adversely affect worker productivity. The benefit of this project is that it will quantify the improvements to occupant comfort and energy savings possible with a PV system. This study will enable PV systems to be evaluated as an alternative to traditional air-conditioning, thereby demonstrating their effectiveness as a means of improving the sustainability rating of commercial office buildings in Australia.Read moreRead less