"Smart Food" - The fulcrum in the energy balance equation. The overall aim of the project is to establish how nutrients best promote an increase in energy expenditure and therefore weight loss. The experiments will be performed in rats using sophisticated technologies to introduce specific combinations of fats, carbohydrates or proteins directly into the stomach and then measure energy expenditure in a specialised type of energy burning rather than energy storing fat called brown adipose tissue. ...."Smart Food" - The fulcrum in the energy balance equation. The overall aim of the project is to establish how nutrients best promote an increase in energy expenditure and therefore weight loss. The experiments will be performed in rats using sophisticated technologies to introduce specific combinations of fats, carbohydrates or proteins directly into the stomach and then measure energy expenditure in a specialised type of energy burning rather than energy storing fat called brown adipose tissue. These experiments will uncover the mechanisms that relate nutrients in the stomach and activation of brown adipose tissue. They will provide a framework on which this project can build a knowledge of smart diets that will allow the effective control of body weight through modulation of energy expenditure. Read moreRead less
Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide t ....Plasticity of gastrointestinal vagal afferents. The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.Read moreRead less
Methodology for assessing the vulnerability of multimodal transport networks and developing remedial measures to safeguard network performance. When transport networks fail, the effects on people and the economy can be devastating. The consequences for Hobart of the 1975 Tasman Bridge collapse provide a prime example. Failure may also result from extreme weather and natural disasters, traffic congestion and incidents, commercial failure, human error, or malevolence (such as sabotage). This proje ....Methodology for assessing the vulnerability of multimodal transport networks and developing remedial measures to safeguard network performance. When transport networks fail, the effects on people and the economy can be devastating. The consequences for Hobart of the 1975 Tasman Bridge collapse provide a prime example. Failure may also result from extreme weather and natural disasters, traffic congestion and incidents, commercial failure, human error, or malevolence (such as sabotage). This project will develop a methodology for auditing a transport network to identify where infrastructure failure will have the worst consequences for movement of people and goods. The research will provide tools for planners to determine critical network locations, and devise strategies and remedial measures to safeguard network performance.Read moreRead less
The mathematics and language of engineering uncertainty, preference and utility. Australian engineering firms are principals in many high-profile projects. To defend their position, they must demonstrate both sound engineering and quality processes, which by international standards includes the traceability of decisions. Yet, there are few tools to vet the multitude of decisions that go into large-scale engineering works. This project aims to form mathematical models of decision-making based on ....The mathematics and language of engineering uncertainty, preference and utility. Australian engineering firms are principals in many high-profile projects. To defend their position, they must demonstrate both sound engineering and quality processes, which by international standards includes the traceability of decisions. Yet, there are few tools to vet the multitude of decisions that go into large-scale engineering works. This project aims to form mathematical models of decision-making based on the language modelling of what is written in engineering documentation about the bases of decisions. The new methods will help decision makers to pinpoint irrationalities in decisions and notify them of possible errors. The research can therefore be applied to important problems in the engineering sector such as risk management.Read moreRead less
The Impact of Strategy on Business Analytics Success. The successful implementation of business analytics systems will enhance the ability of Australian organisations to operate and compete efficiently and effectively within Australia and globally. By understanding the capabilities that lead to improved firm performance and their relationship to strategy, organisations can use the theoretical model to plan for business analytics systems implementation. The model is an original contribution in an ....The Impact of Strategy on Business Analytics Success. The successful implementation of business analytics systems will enhance the ability of Australian organisations to operate and compete efficiently and effectively within Australia and globally. By understanding the capabilities that lead to improved firm performance and their relationship to strategy, organisations can use the theoretical model to plan for business analytics systems implementation. The model is an original contribution in an important area of information systems research and will enhance Australia's reputation as a leader in the area of organizational use of information systems.Read moreRead less
An knowledge-based approach to multi-document text summarisation for automated meta-analysis of the scientific literature. The biomedical sciences produce literature at an exponential rate, and the size of this knowledge base far exceeds the capacity of humans to keep up with the growth in new knowledge. This project will develop computational text summarisation methods to abstract the content of scientific journal articles reporting clinical trials, and develop multi-document summarisation meth ....An knowledge-based approach to multi-document text summarisation for automated meta-analysis of the scientific literature. The biomedical sciences produce literature at an exponential rate, and the size of this knowledge base far exceeds the capacity of humans to keep up with the growth in new knowledge. This project will develop computational text summarisation methods to abstract the content of scientific journal articles reporting clinical trials, and develop multi-document summarisation methods to synthesise these abstracts using automated statistical meta-analysis methods. These methods have broad potential to improve text-summarisation technologies in general, to profoundly enhance our ability to integrate published knowledge, and to make a highly significant and specific contribution to improving the quality of evidence used in health decision-making. Read moreRead less
Defence and Security Risk Assessment using Agent Based Distillations. Today's society continues to be occupied with the idea of risk. The recent events of September 11th, the Bali bombing, SARS, the bush fires in Canberra, and the Tsunami are examples of human-made and natural disasters. These events had dramatic consequences on the social, economic, and political environment and numerous industries. This project offers an innovative methodological paradigm for assessing risk through the transfe ....Defence and Security Risk Assessment using Agent Based Distillations. Today's society continues to be occupied with the idea of risk. The recent events of September 11th, the Bali bombing, SARS, the bush fires in Canberra, and the Tsunami are examples of human-made and natural disasters. These events had dramatic consequences on the social, economic, and political environment and numerous industries. This project offers an innovative methodological paradigm for assessing risk through the transfer of technologies drawn from defence simulations to the safety and security areas. The success of this project will mark a paradigm shift in the area of risk assessment and management.Read moreRead less
Automated texture selection and classification methods for detection of osteoarthritis in knee radiographs. In Australia there are 1-2 million OA sufferers, a condition that costs approximately $9 billion annually. This project will address an important problem of early detection and monitoring of OA and this remains in line with the National Research Priority 2. Potential outcomes of the project will result in better diagnosis and treatment of OA, reduced discomfort to the individual and saving ....Automated texture selection and classification methods for detection of osteoarthritis in knee radiographs. In Australia there are 1-2 million OA sufferers, a condition that costs approximately $9 billion annually. This project will address an important problem of early detection and monitoring of OA and this remains in line with the National Research Priority 2. Potential outcomes of the project will result in better diagnosis and treatment of OA, reduced discomfort to the individual and saving to the national economy. This project will improve existing activity and rehabilitation programs such as exercise of lower limbs and it will help in developing diets for healthy people and OA sufferers.Read moreRead less
The Open Innovation Process: Factors and Technologies that Matter. This project aims to identify approaches to enable firms to find and introduce ideas through open innovation. Open innovation, with its focus on external sources of ideas, is a promising approach for increasing organisational innovation. While uptake of open innovation is on the increase, the lack of understanding of practices and technologies used to successfully introduce it into firms, limits its usefulness and results in wast ....The Open Innovation Process: Factors and Technologies that Matter. This project aims to identify approaches to enable firms to find and introduce ideas through open innovation. Open innovation, with its focus on external sources of ideas, is a promising approach for increasing organisational innovation. While uptake of open innovation is on the increase, the lack of understanding of practices and technologies used to successfully introduce it into firms, limits its usefulness and results in wasted resources. This project aims to investigate open innovation and relevant technologies to identify success factors for the idea generation and assessment phases of open innovation, develop guidelines for their application, identify effective technologies and related recommendations for use, and quantify their impact on innovation.Read moreRead less
Computational Methods for the Social Accounting of Teamwork. The cornerstone of the knowledge industries underlying the Australian economy is not just mechanical efficiency but also teamwork productivity. The increasing trend toward placing Australian employees nearer to their customers means that Australian companies face an even greater challenge in managing effective teamwork. This research examines the pragmatics and theoretical issues of developing computer-based systems that enable real-ti ....Computational Methods for the Social Accounting of Teamwork. The cornerstone of the knowledge industries underlying the Australian economy is not just mechanical efficiency but also teamwork productivity. The increasing trend toward placing Australian employees nearer to their customers means that Australian companies face an even greater challenge in managing effective teamwork. This research examines the pragmatics and theoretical issues of developing computer-based systems that enable real-time assessments of teamwork productivity. Automated assessments of how well relationships are progressing in teams will enable them to realise the same levels of productivity gains that automated workflow management has facilitated.Read moreRead less