The Regulation Of Aromatase In The Context Of Obesity And Postmenopausal Breast Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$436,601.00
Summary
Current hormone therapy for breast cancer using inhibitors of oestrogen formation results in serious side-effects including bone loss, joint pain and possibly cognitive issues. Our current work is aimed at understanding how oestrogen formation is regulated with the goal of developing breast-specific inhibitors of oestrogen formation to obviate these problems. In addition, this work is aimed at devising therapeutic intervention to break the linkage between obesity and breast cancer.
Advancing Obesity Prevention And Control In Australia
Funder
National Health and Medical Research Council
Funding Amount
$461,678.00
Summary
This Fellow will make a significant contribution to the science of childhood obesity prevention. By interrogating high quality data from successful community based interventions the Fellow will identify key systemic components for effective chronic disease prevention. This information will then inform the evaluation of the $80m multiple community Victorian Prevention Community Model involving >25% of the State’s population.
Health and obesity are socially patterned, with lower socio-economic status associated with worse health and higher obesity prevalence. With its high, and increasing prevalence, obesity is likely to be a substantial contributor to increased social inequalities in health. I will estimate the contribution of current obesity trends to social inequalities in diabetes and cardiovascular disease in Australian adults, and identify obesity prevention and management strategies most likely to reduce socia ....Health and obesity are socially patterned, with lower socio-economic status associated with worse health and higher obesity prevalence. With its high, and increasing prevalence, obesity is likely to be a substantial contributor to increased social inequalities in health. I will estimate the contribution of current obesity trends to social inequalities in diabetes and cardiovascular disease in Australian adults, and identify obesity prevention and management strategies most likely to reduce social inequalities in these major health outcomes.Read moreRead less
Defining The Optimal Nutrition In Pregnancy And Early Life To Prevent Childhood Obesity
Funder
National Health and Medical Research Council
Funding Amount
$428,900.00
Summary
Obesity threatens to reduce the length and quality of life of future generations and prevention is a priority. There is now good evidence that the risk a person has of becoming obese is related to the nutritional environment they experience before birth and in early infancy. My research aims to identify nutritional strategies which can be applied safely during pregnancy and infancy to help reduce body fat mass in children and improve their long term health outcomes.
Reducing Risk Factors For Falls And Fracture In Obese Older Australians
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
Australia’s obese older population is growing, and a large number of fractures now occur in obese older adults. This research program aims to reduce falls and fracture risk in obese older adults through innovative exercise programs which target improvements in bone and muscle health, and a wearable device that enables measurement of this type of exercise. The findings will contribute to exercise guidelines which are urgently needed to reduce the costly impact of falls and fracture in Australia.