THE EFFECT OF STRESS AND ENVIRONMENTAL ENRICHMENT ON DISEASE PROGRESSION IN MESIAL TEMPORAL LOBE EPILEPSY
Funder
National Health and Medical Research Council
Funding Amount
$578,201.00
Summary
Mesial temporal lobe epilepsy, the most common form of drug-resistant epilepsy in adults, is a progressive neurodegenerative condition for which there is currently no effective disease modifying treatment. This proposal will explore whether co-morbid stress accelerates disease progression in MTLE, and whether targeting stress pathways by medical and environmental manipulations can mitigate against this.
Sound practice: Supporting sustainable careers in orchestral musicians through Occupational Health and Safety initiatives. This project will produce new knowledge about musician health, well-being and injury prevention and management. It will establish the first injury surveillance system for musicians internationally and the first set of rigorous studies to evaluate the effectiveness of injury management interventions for orchestral musicians. We will establish musician-specific assessment prot ....Sound practice: Supporting sustainable careers in orchestral musicians through Occupational Health and Safety initiatives. This project will produce new knowledge about musician health, well-being and injury prevention and management. It will establish the first injury surveillance system for musicians internationally and the first set of rigorous studies to evaluate the effectiveness of injury management interventions for orchestral musicians. We will establish musician-specific assessment protocols, practices and interventions leading to effective OHS policies, thus enabling global improvement in OHS in the music industry, preventing economic and personal loss from premature career termination due to injury, and assisting, through mentoring, the new generation of young orchestral musicians.Read moreRead less
Dynamic Rollover Occupant Protection (DROP): evaluation and regulation. This projects seeks to establish which occupant crashworthiness attributes a vehicle must possess to prevent injury in a rollover crash. The results will assist regulators, industry and consumer groups understand which critical factors need to be considered to develop rollover crashworthiness regulations, consumer tests and vehicle purchase policy.
Safety management system for heavy vehicle transport. Crashes involving heavy vehicles result in around 330 deaths, over 3000 serious injuries annually, and cost over $6 billion per year. Trucks deliver 72% of Australia's total freight. The quantity delivered by trucks has increased by 40% over a decade and will double over the next 20 years. Conservatively the transport industry contributes about 5.6% to GDP and employs nearly 5% of the workforce. Safe transport is crucial for Australia's heal ....Safety management system for heavy vehicle transport. Crashes involving heavy vehicles result in around 330 deaths, over 3000 serious injuries annually, and cost over $6 billion per year. Trucks deliver 72% of Australia's total freight. The quantity delivered by trucks has increased by 40% over a decade and will double over the next 20 years. Conservatively the transport industry contributes about 5.6% to GDP and employs nearly 5% of the workforce. Safe transport is crucial for Australia's health and economic recovery. If a 10% reduction in casualty truck crashes were to result from this study, the cost benefit ratio would be around 200 to 1.Read moreRead less
Understanding individual, workplace and system level influences on return to work in a changing Australian labour market. This project will identify where challenges arise in return to work after a work-related injury or illness for older workers and people with mental stress claims. The results of this project will help form the basis of policy and program changes to address these issues and enable these groups of workers to have better health and economic outcomes.
Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This proje ....Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This project will rank Australian climate-sensitive/heat attributable diseases by their current burden and projected increase under climate changes, and provide needed scientific evidence to policy-makers in the development, prioritization and implementation of current and future climate change and health adaptation strategies. Read moreRead less
Innovations in Clinical Education for Physiotherapy Students. Australia has workforce shortages and an ageing population. Physiotherapists are key players in promoting and maintaining good health through their leadership in physical activity and rehabilitation to retain Australians in the workforce and to ensure quality of life for our ageing population. There is a national shortage of physiotherapists. Increasing numbers of physiotherapists are being trained, requiring new models of clinical tr ....Innovations in Clinical Education for Physiotherapy Students. Australia has workforce shortages and an ageing population. Physiotherapists are key players in promoting and maintaining good health through their leadership in physical activity and rehabilitation to retain Australians in the workforce and to ensure quality of life for our ageing population. There is a national shortage of physiotherapists. Increasing numbers of physiotherapists are being trained, requiring new models of clinical training as there is no capacity in conventional training to cope with student numbers. This research will develop and evaluate new models of training incorporating standardised patients (actors) and simulators (mannequins) which increase education capacity. Models are transferable to other health professions.Read moreRead less
The Effect Of Stress And Hypercortisolaemia On Limbic Epileptogenesis & Affective Disorder.
Funder
National Health and Medical Research Council
Funding Amount
$380,714.00
Summary
This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is ....This project has the potential to provide novel insights about the causal connections between stress, psychiatric illness (specifically anxiety and depression) and temporal lobe epilepsy (TLE) - the most common form of medical refractory epilepsy in the community. Up to 50% of patients with TLE suffer from anxiety and-or depression. Until relatively recently it had been widely assumed that this was a consequence of the chronic epileptic condition. However, recent evidence suggests that there is a bi-directional relationship, with the psychiatric conditions and stress also acting to aggravate the seizures and even predispose to the development of the epilepsy itself. Apart from gaining insights into causes of TLE, anxiety and depression, this framework has potential public health relevance suggesting approaches to the eventual primary and secondary prevention of both MTLE and its associated psychiatric co-morbidities, a neglected area at present. The use of an animal model allows investigation of aetiological processes that extend over the lifetime, which is exceptionally difficult to achieve in humans. Retrospective studies, such as case-control studies, although an indispensable research methods, are subject to bias and imprecision when it comes to measuring remote past exposures to stress, abuse, and deprivation. If the results of these experiments are consistent with our hypotheses, a very strong case would exist for exploring this relationship in human studies. The data would also provide a strong rationale for more aggressive detection and treatment of these psychiatric co-morbidities in TLE patients, in order to potentially modify the progression of the disorder as well as improve the quality of life of sufferers. The results of intervention studies in animal models may suggest specific mode of treatment to achieve this.Read moreRead less